Scopolamine, also known as hyoscine and devil's breath, is a deliriant tropane alkaloid that occurs naturally in various nightshades including Belladonna and Datura. It has been used for centuries as a poison in some cultures, and is used as a motion sickness medication. Scopolamine is toxic at recreational doses. It appears to impair memory and learning ability.

Dosage

Note: DO NOT take scopolamine in its plant form, for potency can vary drastically.

Recreational doses appear to range between .5mg-1mg (Don't go above 1mg unless you are under medical supervision)

Another form of scopolamine is smoked Buscopan tablets, which contain butylscopolamine, a form of scopolamine that doesn't cross the BBB, but which is converted to scopolamine when burned via pyrolysis. A dose via this method appears to be 2-3 tablets based on Erowid experience reports.

Duration

Onset 20-120 minutes Total 3-24+ hours

Effects

Positive
  • Euphoria
Neutral
  • Pupil dilation
  • Blurred vision
  • Sedation
Negative
  • Delirium
  • Tachycardia
  • Irregular heartbeat
  • Nausea
  • Urinary retention
  • Abnormal breathing
  • Dry mouth
  • Anxiety/Panic
  • Confusion
  • Memory loss
  • Skin reddening
  • Increased body temperature


After Effects

People often report not being able to read fine text for the next day or so.

Harm Reduction

Physostigmine can be used to treat the effects of scopolamine. Do not mix Scopolamine with other anticholinergics, alcohol, zolpidem, or stimulants. Due to the delirium caused by scopolamine, one should not combine scopolamine with other hallucinogens. Having a trip sitter present is extra important with deliriants, for the user is unable to reliably discern what is real.

Pharmacology

Scopolamine is an antimuscarinic at the m1 receptor

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