The Kratom leaf is a psychoactive, traditionally chewed to provide euphoria. Its leaves contain 7-Hydroxymitragynine and mitragynine which act as a μ-opioid receptor agonistA substance that initiates a physiological response when combined with a receptor. like morphine, and can be used to treat chronic pain. The leaves are chewed as an opioid substitute and stimulant in Thailand and especially in the southern peninsula. Kratom is also used in neighboring countries in Southeast Asia where it grows naturally, primarily among the working class. As traditionally used, kratom is not seen as a drug and there is no stigma associated with kratom use or discrimination against kratom eaters. They can also be smoked, brewed as a tea, or made into an extract. It has a relatively long history of human use.
Kratom appears to have been used in Thailand for centuries, recreationally and as an antidiarrhetic. Its use as an opiate substitute in Malaysia was reported in the nineteenth century. Peasants have used it to counteract the tedium of physical labor, similar to the use of coca in South America. The chemistry of its alkaloids was investigated in the 1920s, and mitragynine was isolated in 1923. Kratom leaves became part of the ethnobotanical trade in the United States and Europe in mid 2000. In the early 2000s, stories about the use of kratom to reduce opiod withdrawal effects began circulating on web forums.
Bali- Euphoric and the most classic opiate like among the strains of kratom.
Maeng Da - Energizing and stimulating with pain killing effects.
Red Vein Thai- Similar to Bali with fewer negative side effects.
Super Indo- Similar to Bali with less euphoria.
Super Green Malaysian- Varies between suppliers but is typically more stimulating with little euphoria.
Ultra Enhanced Indo- Most euphoric of the extracts and works well for reducing social anxiety.
Thai Essence- Somewhat weaker than Ultra Enhanced Indo by weight with a bit of a Maeng Da kick.
Full Spectrum Tincture (FST) - The original likely had synthetic 7-hydroxymitragynine but current formulations are basically Ultra Enhanced Indo in liquid form.
Kratom leaves differ greatly in potency, depending on the type, grade, and freshness. Leaves with green veins are often claimed to be more potent than those with red veins, but there is contradictory evidence.
The effects of Mitragyna speciosa are described as being a combination of both stimulation and sedation. The stimulatory effects may be shorter in duration than the sedation effect, coming on faster and fading sooner.
Chronic users have also reported withdrawal symptoms including irritability, runny nose and diarrhea. Withdrawal is generally short-lived and mild, and it may be effectively treated with dihydrocodeine and lofexidine.
Kratom leaves contain the indole alkaloids mitragynine, mitraphylline, 7-hydroxymitragynine, and numerous other alkaloids, including paynanthine, speciogynine, and speciofoline. Mitragynine has traditionally been cited as the primary active chemical in kratom leaves, but some recent evidence points to 7-hydroxymitragynine instead. The pharmacological effects of kratom on humans are not well studied. Its metabolic half-life, protein binding, and elimination characteristics are all unknown. Kratom behaves as a μ-opioid receptor agonistA substance that initiates a physiological response when combined with a receptor., similar to opiates like morphine, although its effects differ significantly from those of opiates.
Mitragynine is a partial agonistA substance that initiates a physiological response when combined with a receptor. of the mu- and delta-opioid receptors. This may account for its apparent efficacy in treating opiate withdrawal (see Erowid). Because kratom acts as both a stimulant and a sedative, secondary alkaloids may be pharmacologically important.
In late August of 2016 the DEA issued a statement indicating intention to place Kratom on Schedule I of the US Controlled Substances Act in the temporary scheduling category. The ban is set to come into effect September 30th 2016.
Kratom is currently a controlled substance in Thailand, Malaysia, Denmark, Israel, Myanmar, New Zealand, Romania, Russia and South Korea.