2C-B vial and powder

2C-B is a psychedelic drug of the 2C-X family. Effects are often described as being more easily managed than other psychedelics; it is often compared to a mixture of a LSD and MDMA. 2C-B is also known for the strong body component of its effects which are alternately described as pleasurable energy or a 'sense of being in the body,' and by others as an unpleasant 'buzzing' or body-load, which is mostly occurring during onset. Users also report open eye visuals in the form of colour distortions, melting like hallucinations, and other minor visual psychedelic effects.

History

2C-B was first synthesized in 1974 by Alexander Shulgin, and it first saw use among the psychiatric community as an aid during therapy. It was considered one of the best drugs for this purpose because of its short duration, relative absence of side effects, and comparably mild nature. Shortly after becoming popular in the medical community, it became popular recreationally. 2C-B was first sold commercially as an aphrodisiac under the trade name "Eros", which was manufactured by the German pharmaceutical company Drittewelle. From many years after it was available as tablets in Dutch smart shops under the name "Nexus".

Dosage

NOTE: DO NOT TAKE THE BELOW DOSING INFORMATION AS A KNOW ALL, PLEASE TAKE CAUTION, AND REMEMBER THAT YOU CAN ALWAYS TAKE MORE, BUT NEVER LESS.

Oral
Light 5-15mg
Common 15-30mg
Strong 30-50mg
Heavy 50mg+

Insufflated/Plugged

Light 5-10mg
Common 10-20mg
Strong 20-30mg
Heavy 30mg+

Dosages from TripSit Factsheets

Duration

Oral
Onset 20-75 minutes
Total 4-8 hours

Insufflated

Onset 1-15 minutes
Total 4-8 hours

Rectal

Onset 5-20 minutes
Total 4-8 hours

Effects

Positive

  • Euphoria
  • Giggling
  • Empathy
  • Personal Insight
  • Enhanced Colours
  • Closed and Open Eye Visuals
  • Enhanced Tactile Sensation

Neutral

  • Decreased Appetite
  • Pupil Dilation
  • Time Dilation

Negative

  • Restlessness
  • Sweating/Chills
  • Nausea
  • Insomnia
  • Muscle Tension
  • Confusion

Aliases

  • Bees
  • Nexus

Chemistry and Pharmacology

Systematic name: 2-(4-bromo-2,5-dimethoxyphenyl)ethanamine

Unlike most hallucinogens, 2C-B has been shown to be a low efficacy serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. 5-HT2A receptor partial agonistA substance that initiates a physiological response when combined with a receptor. or even full antagonistA substance that interferes with or inhibits the physiological action of another.. This suggests that the 5-HT2C receptor is primarily responsible for mediating the effects experienced by users of 2C-B, although functional antagonism of 5-HT2A or activation of the 5-HT2A-coupled phospholipase D pathway may also play a role. The rank order of receptorantagonist potency for this family of drugs is 2C-I > 2C-B > 2C-D > 2C-H.

Research suggests that 2C-B increases dopamineA neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system. levels in the brains of rats, which may contribute to its psychoactivity.

Harm Reduction

2C-B is known as one of the safer psychedelics, with several reported cases of users far exceeding commonly used dosing limits without lasting adverse physical effects. It is also observed to have a low addiction potential. It is a stimulating psychedelic, and therefore it's important to remain hydrated. Refer to Psychedelic Harm Reduction for more information.

Do not take heroic doses thinking that 2C-B is one of the "safer psychedelics".

Interactions

2C-B increases dopamineA neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system. levels and also has an effect on serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being.. Therefore, 2C-B may react negatively with serotonic drugs like anti-depressants and tramadol.

Legal Status

Internationally, 2C-B is a Schedule II drug under the Convention on Psychotropic Substances. In the Netherlands, 2C-B became a list I substance of the Opium Law despite no health incidents occurring. Following the ban, other phenethylamines were sold in place of 2C-B until the Netherlands became the first country in the world to ban 2C-I, 2C-T-2 and 2C-T-7 alongside 2C-B.

  • UK: Class A (Along with all the others in the 2C-X family. (Illegal to produce, supply, or possess.))
  • United States: Schedule I (Illegal to produce, supply, or possess.)

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