DMT

General Information

N,N-Dimethyltryptamine or DMT is a psychoactive substance and a substituted tryptamine.

It is most commonly classified as a psychedelic but also possesses some properties inherent to dissociatives.

Dosage

Oral

DMT is rapidly metabolized by MAO and should therefore be combined with a MAO-inhibitor such as Harmine when taken orally. Otherwise, the effects will be underwhelming or barely noticeable.

Time until onset: between 10 and 60 minutes, depending on prior food intake.

Duration: 3-8 hours until peak effects subside, several more until baseline is restored.

Dosages for DMT, considering MAOs are fully inhibited, vary wildly depending on person, probably due to metabolism in great part. They can go from 30 to 250mg! If its your first time, start on the lower end!

Another factor is whether one is ingesting a whole plant brew or purified extracts. Often in ayahuasca analysis the amount of DMT found is very small (20-30mg), but also often there is redosing in ayahuasca sessions, but also its possible other trace amount of beta-carbolines and alkaloids can improve MAO inhibition, or that other inactive plant substances can help protecting DMT from fast breakdown by any potential active MAO.

There are a few different ways to ingest it orally:

- Dissolved in acidic juice - Rolled inside a bit of smoking paper and swallowed like a pill - Put into 00 Capsules

Suggested doses:

Low dose: 30 to 50mg of both DMT and Harmine

Medium (typical) dose: 100mg of both DMT and Harmine

High dose: 150+mg of DMT, 100mg of Harmine

Smoked-Vaporized

Time until onset: seconds

Low dose: 20 mg

Medium (typical) dose: 40 mg

High dose: 60+ mg

Extracted DMT freebase can be vaporized for very potent effects that last around 10 minutes. DMT is ideally vaporized, as opposed to smoked. Vaporization is achieved by a controlled temperature that does not burn/combust DMT material (and potential impurities), but instead just makes DMT evaporate and be inhaled.

Vaporization is much smoother than smoking. Smoking leads to break down of DMT (and impurity) molecules into potential toxic nitrogen oxides, so not only it is harsher but also there is a significant loss of actives.

Vaporizing can be achieved with improvised vaporizers such as "The Inspirator mkII","The Machine" (both DIY) or commercially sold vaporizing pipes such as the VaporGenie.

Insufflated

Duration: X hours

Onset: X minutes

Low dose: X mg

Medium (typical) dose: X mg

High dose: X mg

This is a method that gets very opposite responses from different people. For many, it hurts too much and isn't effective. For others it works well and pain/discomfort is tolerable, and the effects are worth it. It is unknown what possible health consequences snorting a basic alkaloid such as DMT can have on nasal passages, specially long term use, so we advice caution

Injected

Duration: X hours

Onset: X minutes

Low dose: X mg

Medium (typical) dose: X mg

High dose: X mg

Effects

Positive

-Euphoria

-Feeling of awe

-Realizations about one's life

Neutral

-Time dilation

-Intense hallucinations

-Dissociation

-Loss of comprehension of basic concepts such as ego, language or one's own body.

-Out-of-body experiences

-Unconventional thought patterns

Negative

-Panic attack/Bad trip

-(oral only) Nausea/Vomitting

After effects

-A lasting perspective shift is likely to occur.

-Depersonalization/Derealization can occur after an experience and may last up to several months.

-Some people experience long-term anxiety after an experience while others report a decrease in overall anxiety.

Harm Reduction

-Operating machinery is definitely out of the question while under the influence.

-Be careful for drugs or foods interacting dangerously with any MAO-inhibitors.

-Only trip in a comfortable and positive environment.

Chemistry and Pharmacology

Production

DMT occurs naturally in several plants and may therefore be extracted from them with little chemistry knowledge, requiring no actual synthesis.

Plants containing DMT include Mimosa Hostilis, Psychotria viridis, Codariocalyx motorius and Phalaris arundinacea.

Images

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  DMT freebase molecule (NN-DMT)

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  Opaque DMT crystal

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