Hydrocodone was first synthesized in Germany in 1920 by Carl Mannich and Helene Löwenheim. Hydrocodone is derived from codeine. As a semi-synthetic opioid, it is most often used orallyRoute of administration in which the subject swallows a substance. as a narcotic analgesic and antitussive. Used mostly in combination with Acetaminophen (Vicodin) or Ibuprofen. If you have a drug with acetaminophen in it, we strongly recommend you cold water (CWE) extract the acetaminophen away. CWE methods can be found Here
The following refers to hydrocodone in the form of hydrocodone mixture with Acetaminophen/Ibuprofen. WE ARE NOT DOCTORS. CONSUME THE DOSAGES BELOW AT YOUR OWN RISK.
Any dose of Hydrocodone may be fatal. Do not mix with other drugs or alcohol.
Oral: 10 - 30 minutes
Insufflated - It's a prodrug, don't do it.
IV - It's a prodrug, don't do it.
Half-Life depends on a lot of factors such as weight, BMI, and metabolism, but average plasma half-life is 3.8 hours.
The following products may react negatively with hydrocodone and may cause overdose if mixed together.
Excessive alcohol/grapefruit juice drinking while taking drug that contains APAP, can cause liver damage, other severe medical conditions, and even death.
Do not consume alcohol while under the influence of Hydrocodone. Please consider CWE if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.
Under the Controlled Substances Act (CSA) hydrocodone is listed as both a Schedule II and Schedule III substance depending on the formulation.
*Schedule II lists hydrocodone in pure form and any formulations of combination products containing more than 15 mg hydrocodone per dosage unit. *Schedule III lists hydrocodone in formulations of combination products containing up to 15 mg hydrocodone per dosage unit. *However as of February 23, 2013, all formulations of hydrocodone, regardless of whether they are paired with a combination product or not, have been bumped up to Schedule II.
Hydrocodone was until recently the active antitussive in more than 200 formulations of cough syrups and tablets sold in the United States. In late 2006, the FDA began forcing the recall of many of these formulations due to reports of deaths in infants and children under the age of six. The legal status of drug formulations originally sold between 1938 and 1962—before FDA approval was required—was ambiguous. As a result of FDA enforcement action, by August 2010, 88% of the hydrocodone-containing medications had been removed from the market.
At the present time[when?], doctors, pharmacists, and codeine-sensitive or allergic patients or sensitive to the amounts of histamine released by its metabolites must choose among rapidly dwindling supplies of the Hycodan-Codiclear-Hydromet type syrups, Tussionex—an extended-release suspension similar to the European products Codipertussin (codeine hydrochloride), Paracodin suspension (dihydrocodeine hydroiodide), Tusscodin (nicocodeine hydrochloride) and others—and a handful of weak dihydrocodeine syrups. The low sales volume and Schedule II status of Dilaudid cough syrup predictably leads to under-utilisation of the drug. There are several conflicting views concerning the US availability of cough preparations containing ethylmorphine (also called dionine or codethyline)—Feco Syrup and its equivalents were first marketed circa 1895 and still in common use in the 1940s and 1950s, and the main ingredient is treated like codeine under the Controlled Substances Act of 1970. In the U.S., hydrocodone is always found in combination with other drugs such as paracetamol (also called acetaminophen), aspirin, an NSAID, ibuprofen, an antihistamine, an expectorant, or homatropine methylbromide due to compounding regulations. These combinations are considered C-III substances, prescriptions for which are generally valid for 6 months, including refills. The purpose of the non-controlled drugs in combination is often twofold:
1. To provide increased analgesia via drug synergy. 2. To limit the intake of hydrocodone by causing unpleasant and often unsafe side effects at higher-than-prescribed doses (see below).
The cough preparation Codiclear DH is the purest US hydrocodone item, containing guaifenesin and small amounts of ethanol as active ingredients. As of July 2010, the FDA was considering banning some hydrocodone and oxycodone fixed-combination proprietary prescription drugs—based on the paracetamol content and the widespread occurrence of liver problems. FDA action on this suggestion would ostensibly also affect codeine and dihydrocodeine products such as the Tylenol With Codeine and Panlor series of drugs. In 2010, it was the most prescribed drug in the USA, with 131.2 million prescriptions of hydrocodone (combined with paracetamol) being written