History[edit | edit source]
Hydrocodone was first synthesized in Germany in 1920 by Carl Mannich and Helene Löwenheim. Hydrocodone is derived from codeine. As a semi-synthetic opioid, it is most often used orally as a narcotic analgesic and antitussive. Used mostly in combination with Acetaminophen (Percoset) or Ibuprofen. If you have a drug with acetaminophen in it, we strongly recommend you cold water (CWI) extract the acetaminophen away. CWI methods can be found on google.
Dosage[edit | edit source]
The following refers to hydrocodone in the form of hydrocodone mixture with Acetaminophen/Ibuprofen. WE ARE NOT DOCTORS. CONSUME THE DOSAGES BELOW AT YOUR OWN RISK.
Any dose of Hydrocodone may be fatal. Do not mix with other drugs or alcohol.
10mg - No Tolerance 20-30mg - Low Tolerance 30-50mg - Medium Tolerance 60mg + - High Tolerance
Onset[edit | edit source]
Oral: 10 - 30 minutes Insufflated - Not recommended as snorting APAP is never nice. IV - Not recommended.
Half-Life depends on a lot of factors such as weight, BMI, and metabolism, but average plasma half-life is 3.8 hours.
Potentiators:[edit | edit source]
The following products may react negatively with hydrocodone and may cause overdose if mixed together.
Grapefruit Juice Diphenhydramine
Warning Excessive alcohol/grapefruit juice drinking while taking drug that contains APAP, can cause liver damage, other severe medical conditions, and even death.
Do not consume alcohol while under the influence of Hydrocodone. Please consider CWE if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.
Chemistry and Pharmacology
Europe - Class A
America - Schedule 2