WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times! See below the graphic for important information regarding specific combinations.
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Note: These versions are *out of date*
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Status: Caution
Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
Status: Caution
Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
Status: Unsafe
Note: Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Status: Caution
Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
Status: Caution
Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
Status: Unsafe
Note: Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Status: Caution
Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
Status: Caution
Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
Status: Unsafe
Note: Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
Status: Caution
Note: The 5-MeO class of tryptamines can be unpredictable in their interactions
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Status: Caution
Note: The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
Status: Caution
Note: The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
Status: Low Risk & No Synergy
Note: High doses of caffeine are uncomfortable and this will be magnified by psychedelics
Status: Unsafe
Note: This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures.
Status: Caution
Note: The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Status: Low Risk & Synergy
Note: Ketamine and psychedelics tend to potentiate each other - go slowly.
Status: Caution
Note: As an NMDAN-methyl-D-aspartate receptor. NMDA antagonists are often dissociatives. antagonistA substance that interferes with or inhibits the physiological action of another. MXEMethoxetamine potentiates DOx which can be unpleasantly intense
Status: Unsafe
Note: The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
Status: Unsafe
Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Status: Unsafe
Note: The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
Status: Caution
Note: The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
Status: Unsafe
Note: The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
Status: Caution
Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
Status: Low Risk & Decrease
Note: Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
Status: Low Risk & No Synergy
Note: No unexpected interactions.
Status: Unsafe
Note: Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
Status: Caution
Note: MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-B inhibitors can increase the potency and duration of phenethylamines unpredictably
Status: Caution
Note: The 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. are known to be unpredictable even alone. This combination is best avoided
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Status: Caution
Note: As an NMDAN-methyl-D-aspartate receptor. NMDA antagonists are often dissociatives. antagonistA substance that interferes with or inhibits the physiological action of another. MXEMethoxetamine potentiates NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. which can be unpleasantly intense
Status: Unsafe
Note: Amphetamines and NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. are known to cause seizures and stimulants can increase this risk.
Status: Unsafe
Note: Cocaine and NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
Status: Caution
Note: Caffiene can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle while tripping
Status: Unsafe
Note: Tramadol is well known to lower seizure threshold and NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. have also shown a tendency to cause severe seizures
Status: Caution
Note: MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-B inhibitors can increase the potency and duration of phenethylamines unpredictably
Status: Caution
Note: The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Status: Caution
Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
Status: Caution
Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
Status: Low Risk & No Synergy
Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Status: Unsafe
Note: Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.
Status: Caution
Note: MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-B inhibitors can increase the potency and duration of phenethylamines unpredictably
Status: Caution
Note: Both classes of compounds can be unpredictable alone
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Status: Unsafe
Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences. In extreme cases, they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
Status: Unsafe
Note: Cocaine and 2c-t-x both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
Status: Low Risk & No Synergy
Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Status: Low Risk & Decrease
Note: Both these classes of compound can interact unpredictably. Caution should be exercised.
Status: Low Risk & No Synergy
Note: No expected interactions, some opioids have serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. action, and could lead to SerotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol.
Status: Caution
Note: MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-B inhibitors can increase the potency and duration of phenethylamines unpredictably, which could be dangerous given the unpredictability of the 2C-T-x series
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics. Small amounts can reduce nausea with aMT but take care.
Status: Caution
Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Status: Caution
Note: aMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable
Status: Low Risk & No Synergy
Note: No unexpected interactions
Status: Dangerous
Note: aMT is an MAOIMonoamine oxidase inhibitor are drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate. on its own. Using enzyme inhibitors can greatly reduce predictability of effects.
Status: Low Risk & Synergy
Note: Little information exists about this combination.
Status: Unsafe
Note: Little information exists about this combination.
Status: Caution
Note: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.
Status: Unsafe
Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
Status: Caution
Note: Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care
Status: Unsafe
Note: The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
Status: Low Risk & No Synergy
Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Status: Caution
Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
Status: Low Risk & Synergy
Note: Large amounts of cannabis may cause strong and somewhat unpredictable experiences in combination with MDMA. Cannabis should be saved for towards the end of the experience if possible.
Status: Caution
Note: Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
Status: Low Risk & Synergy
Note: In excess, this combination can cause nausea.
Status: Caution
Note: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
Status: Low Risk & Synergy
Note: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
Status: Caution
Note: No unexpected interactions, though likely to increase blood pressure but not an issue with sensible doses. Moving around on high doses of this combination may be ill advised due to risk of physical injury.
Status: Low Risk & No Synergy
Note: No unexpected interactions.
Status: Dangerous
Note: Both substances cause ataxiaLoss of motor coordination and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Status: Dangerous
Note: Both substances cause ataxiaLoss of motor coordination and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Status: Dangerous
Note: Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Status: Caution
Note: Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
Status: Caution
Note: MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-B inhibitors appear to increase the potency of Ketamine. MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-A inhbitors have some negative reports associated with the combination but there isn't much information available
Status: Caution
Note: There are no reports available about this combination
Status: Caution
Note: Risk of tachycardia, hypertension, and manic states
Status: Caution
Note: There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXEMethoxetamine taken to the end of an MDMA experience does not appear to cause the same issues.
Status: Caution
Note: Stimulants taken with MXEMethoxetamine can lead to hypermanic states much more easily, especially if sleep is avoided.
Status: Low Risk & No Synergy
Note: No likely interactions
Status: Dangerous
Note: There is a high risk of memory loss, vomiting and severe ataxiaLoss of motor coordination from this combination.
Status: Dangerous
Note: Both substances cause ataxiaLoss of motor coordination and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Status: Dangerous
Note: This combination can potentiate the effects of the opioid
Status: Caution
Note: Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess.
Status: Unsafe
Note: MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-B inhibitors appear to increase the potency of MXEMethoxetamine. MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-A inhbitors have some negative reports associated with the combination but there isn't much information available
Status: Caution
Note: Depending on the SSRISelective Serotonin Reuptake Inhibitor this combination can be unpredictable
Status: Unsafe
Note: Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
Status: Unsafe
Note: Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues
Status: Low Risk & No Synergy
Note: High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Status: Dangerous
Note: Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Additionally CNSCentral Nervous System depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau.
Status: Dangerous
Note: Both substances cause ataxiaLoss of motor coordination and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. This combination is hard to predict
Status: Dangerous
Note: CNSCentral Nervous System depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally if one takes dxm, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.
Status: Caution
Note: Small doses of benzos can end a bad trip, but both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and this can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
Status: Dangerous
Note: High risk of serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. syndrome
Status: Dangerous
Note: High risk of serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. syndrome.
Status: Unsafe
Note: This combination can easily lead to hypermanic states
Status: Unsafe
Note: This combination can easily lead to hypermanic states
Status: Unsafe
Note: This combination can easily lead to hypermanic states
Status: Caution
Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Status: Unsafe
Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Status: Dangerous
Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Status: Caution
Note: PCP can reduce opioid tolerance, increasing the risk of overdose
Status: Unsafe
Note: Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely
Status: Dangerous
Note: This combination is very poorly explored
Status: Unsafe
Note: Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Status: Caution
Note: Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
Status: Caution
Note: Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
Status: Caution
Note: Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
Status: Caution
Note: Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
Status: Low Risk & Synergy
Note: Amphetamines increase the neurotoxic effects of MDMA
Status: Caution
Note: This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamineA neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system. releasers like amphetamine
Status: Caution
Note: This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.
Status: Caution
Note: Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
Status: Caution
Note: Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Status: Caution
Note: Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Status: Dangerous
Note: Tramadol and stimulants both increase the risk of seizures.
Status: Low Risk & Decrease
Note: Both can dull each other's effects, so if one wears off before the other it's possible to overdose due to the lack of counteraction
Status: Dangerous
Note: MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-A inhibitors with amphetamine can lead to hypertensive crises.
Status: Caution
Note: Cocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.
Status: Caution
Note: Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA
Status: Caution
Note: Both MDMA and alcohol cause dehydration. Approach this combination with caution, moderation and sufficient hydration. More than a small amount of alcohol will dull the euphoria of MDMA
Status: Caution
Note: Large amounts of GHB/GBL may overwhelm the effects of MDMA on the comedown.
Status: Dangerous
Note: Tramadol and stimulants both increase the risk of seizures.
Status: Dangerous
Note: MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-B inhibitors can increase the potency and duration of phenethylamines unpredictably. MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-A inhibitors with MDMA will lead to hypertensive crises.
Status: Caution
Note: Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.
Status: Unsafe
Note: Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol less. Cocaine is potentiated somewhat by alcohol because of the formation of cocaethylene.
Status: Caution
Note: Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. Likewise the G can wear off and leave a dangerous concentration of cocaine behind
Status: Dangerous
Note: Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Status: Dangerous
Note: Tramadol and stimulants both increase the risk of seizures.
Status: Dangerous
Note: This combination is poorly explored
Status: Low Risk & No Synergy
Note: May reduce each others' effectiveness. Cocaine can reduce mental stability and therefore exacerbate conditions which SSRIs are used to treat.
Status: Dangerous
Note: Even in very low doses this combination rapidly leads to memory loss, severe ataxiaLoss of motor coordination and unconsciousness. There is a high risk of vomit aspiration while unconscious.
Status: Dangerous
Note: Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely
Status: Dangerous
Note: Heavy CNSCentral Nervous System depressants, risk of seizures. Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.
Status: Dangerous
Note: Ethanol ingestion may potentiate the CNSCentral Nervous System effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.
Status: Unsafe
Note: Tyramine found in many alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.
Status: Caution
Note: Alcohol may potentiate some of the pharmacologic effects of CNSCentral Nervous System-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
Status: Dangerous
Note: The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position
Status: Dangerous
Note: The sedative effects of this combination can lead to dangerous respiratory depression.
Status: Dangerous
Note: The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
Status: Dangerous
Note: Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present
Status: Dangerous
Note: Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely
Status: Caution
Note: Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.
Status: Low Risk & No Synergy
Note: There have been very infrequent reports of a risk of serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. syndrome with this combination, though this should not be a practical concern.
Status: Dangerous
Note: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present. Vomit aspiration a risk when passed out, lay down in recovery position if ingested.
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