(→Amphetamines & Benzodiazepines) |
(→Substance class description) |
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** http://www.ncbi.nlm.nih.gov/pubmed/15214625 | ** http://www.ncbi.nlm.nih.gov/pubmed/15214625 | ||
** http://www.ncbi.nlm.nih.gov/pubmed/16356341 | ** http://www.ncbi.nlm.nih.gov/pubmed/16356341 | ||
+ | |||
+ | === Opioids === | ||
+ | |||
+ | * Tramadol acts as a μ-opioid receptor agonist, serotonin releasing agent (SRA), serotonin and norepinephrine reuptake inhibitor (SNRI), NMDA receptor antagonist, 5-HT2C receptor antagonist, 5 nicotinic acetylcholine receptor antagonist, TRPV1 receptor agonist, and M1 and M3 muscarinic acetylcholine receptor antagonist. It can cause seizures, serotonin syndrome and even death when combined with certain stimulants and other reuptake inhibitors. | ||
+ | ** https://www.ncbi.nlm.nih.gov/pubmed/2849950 | ||
+ | ** https://www.ncbi.nlm.nih.gov/pubmed/8955860 | ||
+ | ** https://www.ncbi.nlm.nih.gov/pubmed/9671098 | ||
+ | ** https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908625/ | ||
+ | ** https://www.ncbi.nlm.nih.gov/pubmed/9389855 | ||
+ | ** https://www.ncbi.nlm.nih.gov/pubmed/8955860 | ||
+ | ** https://www.ncbi.nlm.nih.gov/pubmed/15845694 | ||
+ | ** https://www.ncbi.nlm.nih.gov/pubmed/15105221 | ||
+ | ** https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573343/ | ||
+ | ** http://jpet.aspetjournals.org/content/299/1/255.long | ||
+ | ** https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572317/ | ||
= Specific combinations with references (work in progress) = | = Specific combinations with references (work in progress) = |
WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times!
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
http://www.ncbi.nlm.nih.gov/pubmed/16483730
http://www.ncbi.nlm.nih.gov/pubmed/547279
http://www.ncbi.nlm.nih.gov/pubmed/3006089
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://www.ncbi.nlm.nih.gov/pubmed/8788508
http://www.ncbi.nlm.nih.gov/pubmed/108709
https://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2439&DocPartID=2199
http://www.nature.com/npp/journal/v14/n6/full/1380431a.html
http://www.ncbi.nlm.nih.gov/pubmed/8726753
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://www.ncbi.nlm.nih.gov/pubmed/1208759
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full
http://onlinelibrary.wiley.com/doi/10.1002/jemt.22045/abstract
http://www.ncbi.nlm.nih.gov/pubmed/16483730
http://www.ncbi.nlm.nih.gov/pubmed/21224020
http://www.sciencedirect.com/science/article/pii/S0014488607002543
http://www.ncbi.nlm.nih.gov/pubmed/25060403
http://www.sciencedirect.com/science/article/pii/S0014488607002543
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224745/
http://www.ncbi.nlm.nih.gov/pubmed/17320309
http://www.ncbi.nlm.nih.gov/pubmed/22671762
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02065.x/full
http://link.springer.com/article/10.1007/s00213-010-1864-1
http://www.sciencedirect.com/science/article/pii/S0028390805003114
http://www.ncbi.nlm.nih.gov/pubmed/21040238
http://www.ncbi.nlm.nih.gov/pubmed/21756931
http://www.ncbi.nlm.nih.gov/pubmed/16234132
http://www.ncbi.nlm.nih.gov/pubmed/22554869
http://www.ncbi.nlm.nih.gov/pubmed/20730418
http://www.ncbi.nlm.nih.gov/pubmed/16483730
http://www.ncbi.nlm.nih.gov/pubmed/23761390
http://www.ncbi.nlm.nih.gov/pubmed/20195220
http://www.ncbi.nlm.nih.gov/pubmed/20001110
http://www.ncbi.nlm.nih.gov/pubmed/20837047
http://www.ncbi.nlm.nih.gov/pubmed/15274975
http://www.ncbi.nlm.nih.gov/pubmed/15739105
http://www.ncbi.nlm.nih.gov/pubmed/7782758
http://www.ncbi.nlm.nih.gov/pubmed/7782758
http://www.ncbi.nlm.nih.gov/pubmed/16483730
No study, but MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). B inhibitors should enhance the effects, no interaction with MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). A.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454351/
http://www.ncbi.nlm.nih.gov/pubmed/17157368 (?)
http://www.ncbi.nlm.nih.gov/pubmed/2891392
http://www.if-pan.krakow.pl/pjp/pdf/2013/3_593.pdf
http://www.ncbi.nlm.nih.gov/pubmed/23391344
http://www.ncbi.nlm.nih.gov/pubmed/20513454
http://www.ncbi.nlm.nih.gov/pubmed/16005413
http://www.ncbi.nlm.nih.gov/pubmed/18676387
http://www.ncbi.nlm.nih.gov/pubmed/17381671
http://www.ncbi.nlm.nih.gov/pubmed/12842359
http://www.ncbi.nlm.nih.gov/pubmed/16051647
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446479/
http://www.ncbi.nlm.nih.gov/pubmed/9435993
http://www.ncbi.nlm.nih.gov/pubmed/24577320