Diphenidine: Difference between revisions

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Diphenidine (1-(1,2-diphenylethyl)piperidine) is a dissociative anesthetic drug.
== History ==
The first synthesis of diphenidine was published in 1924 by Christiaen who used a modified Brulyants reaction, similar to the reaction later used by Maddox in the first PCP synthesis.
While diphenidine was never used or investigated medically, several related compounds have been and include the withdrawn analgesic lefetamine and investigational compounds such as AstraZenica’s NMDA antagonist antidepressant Lanicemine, and neurodegenerative disease and anti-epileptic agent Remacemide.
Shortly after the UK arylcyclohexylamine ban in early 2013, diphenidine and its 2-MeO derivative methoxphenidine emerged on the RC market.
= Dosage =
Diphenidine can also be insufflated, vaporized and injected. Start with low doses and work your way up.
== Oral ==
Threshold: 50 mg
Light: 70-85 mg
Common: 85-110 mg
Heavy: 110-150 mg
= Duration =
== Oral ==
Onset: 15-30 minutes
Total Duration: 2-5 hours
After-effects: 4-24 hours
= Effects =
== Postive ==
* Stimulation
* Euphoria
* Disconnected thoughts
* Shifts in perception of reality
== Neutral ==
* Altered time perception
* Disrupted speech patterns
* Distorted sensory perceptions, hallucinations
* Confusion
== Negative ==
* Severe dissociation, depersonalization
* Ataxia (loss of motor coordination)
* Temporary amnesia
= Harm Reduction =
* Do not drive or operate heavy machinery.
* Avoid walking or moving in general if possible.
* Always experiment with drugs with a sober friend in a safe place
== Potentiators ==
* CNS depressants
== Interactions ==
It is currently unknown whether diphenidine is a reuptake inhibitor of serotonin (SRI), if that is the case do '''NOT''' ever combine it with other SRIs (such as MXE) or SSRIs.
Check out our [[Drug Combinations]] page and chart for interactions and combinations of common drugs.
= Chemistry and Pharmacology =
Diphenidine is a NMDA antagonist and possibly a reuptake inhibitor of serotonin or dopamine.
= Legal status=
Diphenidine is, as of July 2014, not a controlled substance in any country.
= Links =
[http://www.bluelight.org/vb/threads/668291-The-Big-amp-Dandy-Diphenidine-Thread Bluelight Big & Dandy thread]
[http://0-www.ncbi.nlm.nih.gov.elis.tmu.edu.tw/pubmed/24678061 From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.]
[[Category:Dissociative]]
[[Category:Dissociative]]
[[Category:Drugs]]
[[Category:Drugs]]

Revision as of 12:28, 14 July 2014

Diphenidine (1-(1,2-diphenylethyl)piperidine) is a dissociative anesthetic drug.

History

The first synthesis of diphenidine was published in 1924 by Christiaen who used a modified Brulyants reaction, similar to the reaction later used by Maddox in the first PCP synthesis.

While diphenidine was never used or investigated medically, several related compounds have been and include the withdrawn analgesic lefetamine and investigational compounds such as AstraZenica’s NMDA antagonist antidepressant Lanicemine, and neurodegenerative disease and anti-epileptic agent Remacemide.

Shortly after the UK arylcyclohexylamine ban in early 2013, diphenidine and its 2-MeO derivative methoxphenidine emerged on the RC market.

Dosage

Diphenidine can also be insufflated, vaporized and injected. Start with low doses and work your way up.

Oral

Threshold: 50 mg

Light: 70-85 mg

Common: 85-110 mg

Heavy: 110-150 mg

Duration

Oral

Onset: 15-30 minutes

Total Duration: 2-5 hours

After-effects: 4-24 hours

Effects

Postive

  • Stimulation
  • Euphoria
  • Disconnected thoughts
  • Shifts in perception of reality

Neutral

  • Altered time perception
  • Disrupted speech patterns
  • Distorted sensory perceptions, hallucinations
  • Confusion

Negative

  • Severe dissociation, depersonalization
  • Ataxia (loss of motor coordination)
  • Temporary amnesia

Harm Reduction

  • Do not drive or operate heavy machinery.
  • Avoid walking or moving in general if possible.
  • Always experiment with drugs with a sober friend in a safe place

Potentiators

  • CNS depressants

Interactions

It is currently unknown whether diphenidine is a reuptake inhibitor of serotonin (SRI), if that is the case do NOT ever combine it with other SRIs (such as MXE) or SSRIs.

Check out our Drug Combinations page and chart for interactions and combinations of common drugs.

Chemistry and Pharmacology

Diphenidine is a NMDA antagonist and possibly a reuptake inhibitor of serotonin or dopamine.

Legal status

Diphenidine is, as of July 2014, not a controlled substance in any country.

Links

Bluelight Big & Dandy thread

From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.