O-Acetylpsilocin (also known as Psilacetin, 4-Acetoxy-DMT, or 4-AcO-DMT) is a synthetically produced psychoactive drug with a limited history of use. Its effects and duration are similar to those of psilocybin/psilocin although it is sometimes described as "warmer" or "more euphoric" than psilocybin-containing mushrooms. It is probably metabolically converted into psilocin in the body, but there are also reasons to believe that 4-acetoxy-DMT might itself be active in the brain, producing effects that are distinct from psilocin.


Ideal dosage varies widely between individuals. Some people get very heavy mental effects and others find the mental effects light. It's best to start low and see how you are impacted.


Light: 5-10mg

Common: 10-25mg

Strong: 25-40mg

Heavy: 40mg+ (while extremely strong doses of 4-aco-dmt seem to be well tolerated, it is ill-advised to jump into extremely large doses)



Onset: 20-45 minutes (empty stomach) up to 120 minutes depending on stomach contents

Peak: 3~4 hours

Total Duration: 6~8 hours

After-effects: 2~4 hours



  • Mood lift, euphoria
  • Increased giggling and laughing
  • Creative, philosophical or deep thinking : ideas flow more easily
  • Boring tasks or entertainment can become more interesting or funny
  • Sensation of insight
  • Life-changing spiritual experience
  • Intense feelings of wonder


  • Feeling more emotionally sensitive
  • General change in consciousness (as with many psychoactives)
  • Time perception alteration
  • Sensitivity to light; lights seem brighter
  • Starring and rainbow patterns around pinpoint lights
  • Increased detection of motion in peripheral vision
  • Open and closed-eye visuals (common at medium or stronger dose)
  • Pupil dilation
  • Sensation of energy or buzzing in the nevous system/peripheral limbs


  • Intense feelings of fear
  • Mild to severe anxiety
  • Dizziness, confusion
  • Confusion


Check out our Drug Combinations page and chart for interactions and combinations of common drugs.

Legal status

Class A in the UK under the Misuse of Drugs Act[1]


  1. http://www.legislation.gov.uk/uksi/1977/1243/contents/made

Top Contributors