Clonazolam
Clonazolam (also known as Clonitrazolam) is a novel psychoactive class::depressant substance of the chemical class::benzodiazepine chemical class which produces anxiolytic, sedative, muscle relaxant, and amnesic effects when administered. This compound is a novel research chemical derivative of the FDA-approved drugs clonazepam (Klonopin, Rivitrol) and alprazolam (Xanax). Clonazolam is reported to be roughly 2.5x as potent as alprazolam.
History
The synthesis of clonazolam was first reported in 1971. It was described as the most active compound in the series tested.[1][2]
Very little is known about this substance, but it has recently become easily accessible through online research chemical vendors where it is being sold as a designer drug.[3][4]
Usage
Ritual use, different types of administration and how to do it, etc.
Dosage
General note/warning about dosage
| Threshold | x mg |
| Light | x mg |
| Common | x mg |
| Strong | x mg |
Duration
| Onset | x minutes |
| Total | x hours |
| After-effects | x hours (dose-dependent) |
Effects
Postive
- effect
Neutral
- effect
Negative
- effect
Images
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Example image 1
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Example image with link: TripSit Rules
Harm Reduction
Clonazolam is reputed to be highly potent, and concerns have been raised that it and flubromazolam may pose comparatively higher risks than other designer benzodiazepines due to their ability to produce strong sedation and amnesia at oral doses as low as 0.5 mg, or 500 micrograms (ug).[5] It is reported to have a medium-length onset of action (20 - 60 minutes).
- warning 1
- warning 2
WARNING
Due to its extremely high potency, it is often found on blotter paper or in volumetrically dosed solutions. Ingestion of raw clonazolam powder is unsafe due to its microgram-range potency and the ease in which it can lead to multi-day blackouts.
Potentiators
- substance 1
- substance 2
Interactions
Check out our Drug Combinations page and chart for interactions and combinations of common drugs.
Chemistry and Pharmacology
LD50
Legal status
- USA:
- UK:
Links
Further Reading
Off-Site Resources
- ↑ 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines which have central nervous system depressant activity (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/5165540
- ↑ Triazolobenzazepines, process and intermediates for their preparation and medicines containing them | https://www.google.com/patents/EP0072029B1
- ↑ Characterization of the four designer benzodiazepines clonazolam, deschloroetizolam, flubromazolam, and meclonazepam, and identification of their in vitro metabolites | http://link.springer.com/article/10.1007%2Fs11419-015-0277-6
- ↑ Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes. (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/27071765
- ↑ Designer benzodiazepines: A new challenge (PubMed.gov / NCBI) | https://www.ncbi.nlm.nih.gov/pubmed/26043347