3-MeO-PCP
3-Methoxyphencyclidine (3-MeO-PCP) is a dissociative anesthetic drug that is sold online as a research chemical.
The effects are often described as more euphoric and mentally clearer than many related compounds.
History
A 1965 article published by Maddox described the synthesis of 2-MeO-PCP and 4-MeO-PCP. Preparation of 3-MeO-PCP was described later in 1979 by Geneste et al.
The compound was first synthesized in 1979 to investigate the structure-activity relationship of phencyclidine derivatives. The activity of 3-MeO-PCP in man was not described until 1999 when a chemist using the pseudonym John Q. Beagle wrote that 3-MeO-PCP was qualitatively similar to PCP with comparable potency.
Dosage
Use a precise milligram scale to avoid overdosing.
| Threshold | 1.5-3 mg |
| Light | 3-5 mg |
| Common | 5-8 mg |
| Strong | 8-12 mg |
Duration
| Onset | 20-40 minutes |
| Total | 4-6 hours |
| After-effects | 2-48 hours |
Insufflated onset is approximately 5-15 minutes and the duration is a bit shorter.
Effects
Postive
- Increase in energy / stimulation
- Euphoria
- Pleasant mental and/or body high
- Music appreciation
- Disconnected thoughts
- Sense of calm
- Increased sociability, loss of inhibitions
- Closed- and open-eye visuals
- Shifts in perception of reality
Neutral
- Increased heart rate (lower doses)
- Altered time perception
- Disrupted speech patterns
- Analgesia (decreased pain awareness) and numbness
- Distorted sensory perceptions, hallucinations
- Unusual and unpredictable behavior
- Mild to moderate dissociation
- Confusion, disorientation
Negative
- Disturbing hallucinations and/or delusions
- Anxiety, paranoia
- Severe dissociation, depersonalization
- Ataxia (loss of motor coordination)
- Psychotic episodes
- Nausea, vomiting
- Temporary amnesia
- Severe distortion or loss of auditory/visual perception
Harm Reduction
Do not drive or operate heavy machinery. Take extra precaution if going out in public on 3-MeO-PCP.
WARNING
We recommend to have a sober friend with you when taking this substance for the first time.
Interactions
Check out our Drug Combinations page and chart for interactions and combinations of common drugs.
Specifically, do not mix with alcohol or benzodiazepines.
Chemistry and Pharmacology
3-MeO-PCP binds to the NMDA receptor with higher affinity than PCP and has the highest affinity of the three isomeric anisyl-substitutions, followed by 2-MeO-PCP and 4-MeO-PCP. It is also a Serotonin Reuptake Inhibitor (SRI).
3-MeO-PCP hydrochloride is a white crystalline solid with a melting point of 204-205°C.
3-MeO-PCP has a Ki of 20 nM for the NMDA receptor, 216 nM for the serotonin transporter and 42 for the sigma1 receptor.
Legal status
UK: Class B, as are all arylcyclohexamines.
US: Covered by the analogue act if sold for human consumption.