General Information
Methoxamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of Ketamine and PCP. It was first publicly reported in 2010. Some say it's similar to Ketamine or a high dose DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.
Dosage
Oral
| Threshold |
5-20mg
|
| Low |
10-30mg
|
| Common |
40-60mg
|
| Strong |
50-100mg+
|
Insufflated
| Threshold |
5-15mg
|
| Low |
15-30mg
|
| Common |
30-50mg
|
| Strong |
50-75mg
|
| Hole |
75-100mg+
|
Sublingual
| Threshold |
5-10mg
|
| Low |
10-20mg
|
| Common |
40-60mg
|
| Strong |
60-75mg
|
| Hole |
75-100mg+
|
Duration
Oral
| Onset |
30-60 minutes
|
| Total |
3-6 hours
|
| After-effects |
2-48 hours (dose-dependent)
|
Insufflated
| Onset |
5-40 minutes
|
| Total |
3-6 hours
|
| After-effects |
2-48 hours (dose-dependent)
|
Sublingual
| Onset |
15-45 minutes
|
| Total |
3-6 hours
|
| After-effects |
2-48 hours (dose-dependent)
|
Effects
Positive
- Euphoria, mood lift
- Sense of calm and serenity
- Vivid recall of past memories and dreams
- Closed- and open-eye visuals (common)
- Out-of-body experience (less intense then ketamine)
Neutral
- Distortion or loss of sensory perceptions (common)
- Dissociation of mind from body
- Sweating
- Analgesia, numbness
- Significant change in perception of time
- Increase in heart rate
- Confusion, disorientation
Negative
- Risk of psychological dependency
- Nasal discomfort upon insufflation
- Blacking out and forgetting one has taken a drug
- Discomfort, pain or numbness at injection site (with IM)
- Severe confusion, disorganised thinking
- Vertigo, spinning sensation (risk of injury)
- Nausea, vomiting
- Susceptibility to accidents (from uncoordination and change in perception of body and time)
- Severe dissociation, depersonalisation
- Loss of consciousness
- Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)
Harm Reduction
- Avoid driving at all costs.
- Avoid walking or moving around in general if you are on a medium to hole dose.
- Taking this on a non-empty substance could lead to nausea.
Interactions
Drug Combinations
Links
Wikipedia
Erowid
Drugs-Forum
/r/Drugs FAQ