Methoxetamine: Difference between revisions

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= General Information =
= General Information =
Methoxamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of Ketamine and PCP. It was first publicly reported in 2010. Some say it's similar to Ketamine or a high dose DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.
Methoxamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or a high dose DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.


= Dosage =
= Dosage =
== Oral ==
Threshold: 5-20mg


Low: 10-30mg
{| class="wikitable"
|+ Oral
|-
| Threshold || 5-20mg
|-
| Low || 10-30mg
|-
| Common || 40-60mg
|-
| Strong || 50-100mg+
|}


Common: 40-60mg
{| class="wikitable"
|+ Insufflated
|-
| Threshold || 5-15mg
|-
| Low || 15-30mg
|-
| Common || 30-50mg
|-
| Strong || 50-75mg
|-
| Hole || 75-100mg+
|}


Strong: 50-100mg+
{| class="wikitable"
 
|+ Sublingual
== Insufflated ==
|-
Threshold: 5-15mg
| Threshold || 5-10mg
 
|-
Low: 15-30mg
| Low || 10-20mg
 
|-
Medium: 30-50mg
| Common || 40-60mg
 
|-
Strong: 50-75mg
| Strong || 60-75mg
 
|-
Hole: 75-100mg+
| Hole || 75-100mg+
 
|}
== Sublingual ==
Threshold: 5-10mg
 
Low: 10-25mg
 
Medium: 40-60mg
 
Strong: 60-75mg
 
Hole: 75-100mg


= Duration =
= Duration =
== Oral ==
Onset: 30-60 minutes
Total duration: 3-6 hours
After effects (depends on dose): 2-48 hours
== Insufflated ==
Onst: 5-20 minutes
Total duration: 3-6 hours
After effects (depends on dose): 2-48 hours


== Sublingual ==
{| class="wikitable"
Onset: 15-45 minutes
|+ Oral
|-
| Onset || 30-60 minutes
|-
| Total || 3-6 hours
|-
| After-effects || 2-48 hours (dose-dependent)
|}


Total duration: 3-6 hours
{| class="wikitable"
|+ Insufflated
|-
| Onset || 5-40 minutes
|-
| Total || 3-6 hours
|-
| After-effects || 2-48 hours (dose-dependent)
|}


After effects (depends on dose): 2-48 hours
{| class="wikitable"
|+ Sublingual
|-
| Onset || 15-45 minutes
|-
| Total || 3-6 hours
|-
| After-effects || 2-48 hours (dose-dependent)
|}


= Effects =
= Effects =

Revision as of 13:16, 16 July 2014

General Information

Methoxamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of Ketamine and PCP. It was first publicly reported in 2010. Some say it's similar to Ketamine or a high dose DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.

Dosage

Oral
Threshold 5-20mg
Low 10-30mg
Common 40-60mg
Strong 50-100mg+
Insufflated
Threshold 5-15mg
Low 15-30mg
Common 30-50mg
Strong 50-75mg
Hole 75-100mg+
Sublingual
Threshold 5-10mg
Low 10-20mg
Common 40-60mg
Strong 60-75mg
Hole 75-100mg+

Duration

Oral
Onset 30-60 minutes
Total 3-6 hours
After-effects 2-48 hours (dose-dependent)
Insufflated
Onset 5-40 minutes
Total 3-6 hours
After-effects 2-48 hours (dose-dependent)
Sublingual
Onset 15-45 minutes
Total 3-6 hours
After-effects 2-48 hours (dose-dependent)

Effects

Positive

  • Euphoria, mood lift
  • Sense of calm and serenity
  • Vivid recall of past memories and dreams
  • Closed- and open-eye visuals (common)
  • Out-of-body experience (less intense then ketamine)

Neutral

  • Distortion or loss of sensory perceptions (common)
  • Dissociation of mind from body
  • Sweating
  • Analgesia, numbness
  • Significant change in perception of time
  • Increase in heart rate
  • Confusion, disorientation

Negative

  • Risk of psychological dependency
  • Nasal discomfort upon insufflation
  • Blacking out and forgetting one has taken a drug
  • Discomfort, pain or numbness at injection site (with IM)
  • Severe confusion, disorganised thinking
  • Vertigo, spinning sensation (risk of injury)
  • Nausea, vomiting
  • Susceptibility to accidents (from uncoordination and change in perception of body and time)
  • Severe dissociation, depersonalisation
  • Loss of consciousness
  • Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)

Harm Reduction

  • Avoid driving at all costs.
  • Avoid walking or moving around in general if you are on a medium to hole dose.
  • Taking this on a non-empty substance could lead to nausea.

Interactions

Drug Combinations

Links

Wikipedia

Erowid

Drugs-Forum

/r/Drugs FAQ

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