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| <table style="font-family: Arial, Helvetica, sans-serif; font-size: 9pt;" width="100%" border="0" cellspacing="0" cellpadding="0">
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| <tr>
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| <td valign="top" width="50%"><strong>Other Names</strong>
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| Agarin, 5-(aminomethyl)-3- [2H] -isoxazolone, pyroibotenic
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| acid, 3-hydroxy-5-aminomethyl-isoxazole
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| Substance type: amino acid, isoxazole derivative
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| Muscimol was first described in 1964 as a constituent
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| of Amanita pantherina. Muscimol is the
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| decarboxylated product of ibotenic acid and is
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| considered to be more psychoactive than it. Some
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| 15 to 20 mg is regarded as a psychoactive dosage
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| (Muller and Eugster 1965; Ott 1993,446*; Scotti et
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| al. 1969).
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| Muscimol is an analog of the neurotransmitter
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| GABA (gamma amino butyric acid) and docks to
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| its receptor (Johnston 1971). Kavapyrones (cf.
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| Piper methysticum) also bind to the same receptor.
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| Ibotenic acid as well as muscimol were detected
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| in the urine of people who had eaten fly agaric
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| mushrooms (Amanita muscaria) about an hour
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| earlier. An experiment with mice conducted by the
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| same team of researchers found that the amount of
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| active constituents in the urine passed by one
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| inebriated animal was not sufficient to inebriate
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| another animal (Ott et al. 1975).</td>
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| <td valign="top" width="53%"><strong>Commercial Forms and Regulations
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| </strong>Muscimol can be purchased from chemical suppliers.
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| The substance is legal and is not subject to
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| any specific regulations.
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| <strong>
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| Literature</strong>
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| See also the entries for Amanita muscaria and
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| ibotenic acid.
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| Johnston, G. A. R. 1971. Muscimol and the uptake of
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| ,),-aminobutyric acid by rat brain slices.
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| Psychopharmacologia 22:230.
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| Muller, G. F. R., and C. H. Eugster. 1965. Muscimol,
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| ein pharmakodynamisch wirksamer Stoff aus
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| Amanita muscaria. Helvetica Chemica Acta
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| 48:910-26.
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| Ott, Jonathan, Preston S. Wheaton, and William
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| Scott Chilton. 1975. Fate of muscimol in the
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| mouse. Physiol. Chem. and Physics 7:381-84.
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| Scotti de Carolis, A., et al. 1969.
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| Neuropharmacological investigations on
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| muscimol, a psychotropic drug extracted from
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| Amanita muscaria. Psychopharmacologia
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| 15:186-95.</td>
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| </tr>
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| </table>
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| [[Category:Drugs]] | | [[Category:Drugs]] |
| [[Category:Psychedelic]] | | [[Category:Psychedelic]] |