Methoxetamine: Difference between revisions

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= General Information =
= General Information =
Methoxamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of Ketamine and PCP. It was first publicly reported in 2010. Some say it's similar to Ketamine or a high dose DXM. It has been shown to act as an NMDA receptor antagonist and Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.
Methoxamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of Ketamine and PCP. It was first publicly reported in 2010. Some say it's similar to Ketamine or a high dose DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.


= Dosage =
= Dosage =
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After effects (depends on dose): 2-48 hours
After effects (depends on dose): 2-48 hours
= Effects =
== Positive ==
* Euphoria, mood lift
* Sense of calm and serenity
* Vivid recall of past memories and dreams
* Closed- and open-eye visuals (common)
* Out-of-body experience (less intense then ketamine)
= Neutral =
Distortion or loss of sensory perceptions (common)
Dissociation of mind from body
Sweating
Analgesia, numbness
Significant change in perception of time
Increase in heart rate
Confusion, disorientation
= Negative =
* Risk of psychological dependency
* Nasal discomfort upon insufflation
* Blacking out and forgetting one has taken a drug
* Discomfort, pain or numbness at injection site (with IM)
* Severe confusion, disorganised thinking
* Vertigo, spinning sensation (risk of injury)
* Nausea, vomiting
* Susceptibility to accidents (from uncoordination and change in perception of body and time)
* Severe dissociation, depersonalisation
* Loss of consciousness
* Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)


= Harm Reduction =
= Harm Reduction =

Revision as of 04:52, 9 July 2014

General Information

Methoxamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of Ketamine and PCP. It was first publicly reported in 2010. Some say it's similar to Ketamine or a high dose DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.

Dosage

Oral

Threshold: 5-20mg

Low: 10-30mg

Common: 40-60mg

Strong: 50-100mg+

Insufflated

Threshold: 5-15mg

Low: 15-30mg

Medium: 30-50mg

Strong: 50-75mg

Hole: 75-100mg+

Sublingual

Threshold: 5-10mg

Low: 10-25mg

Medium: 40-60mg

Strong: 60-75mg

Hole: 75-100mg

Duration

Oral

Onset: 30-60 minutes

Total duration: 3-6 hours

After effects (depends on dose): 2-48 hours

Insufflated

Onst: 5-20 minutes

Total duration: 3-6 hours

After effects (depends on dose): 2-48 hours

Sublingual

Onset: 15-45 minutes

Total duration: 3-6 hours

After effects (depends on dose): 2-48 hours

Effects

Positive

  • Euphoria, mood lift
  • Sense of calm and serenity
  • Vivid recall of past memories and dreams
  • Closed- and open-eye visuals (common)
  • Out-of-body experience (less intense then ketamine)

Neutral

Distortion or loss of sensory perceptions (common) Dissociation of mind from body Sweating Analgesia, numbness Significant change in perception of time Increase in heart rate Confusion, disorientation

Negative

  • Risk of psychological dependency
  • Nasal discomfort upon insufflation
  • Blacking out and forgetting one has taken a drug
  • Discomfort, pain or numbness at injection site (with IM)
  • Severe confusion, disorganised thinking
  • Vertigo, spinning sensation (risk of injury)
  • Nausea, vomiting
  • Susceptibility to accidents (from uncoordination and change in perception of body and time)
  • Severe dissociation, depersonalisation
  • Loss of consciousness
  • Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)


Harm Reduction

  • Avoid driving at all costs.
  • Avoid walking or moving around in general if you are on a medium to hole dose.
  • Taking this on a non-empty substance could lead to nausea.