Mephedrone

General Information

Mephedrone (4-Methoxymethcathinone, 4-MMC, and also known by slang terms such as 'meow' and 'M-CAT') is a synthetic stimulant with empathogenic effects. A research chemical first developed as an analogue of MDMA in 1929, it eventually became popular among recreational drug users between 2007 and 2009 as it became available for purchase online. As a result, it was used increasingly in Europe, Australia, and New Zealand, associated with several deaths, and as a result was controlled in some countries.

Because of the similarity in names, it is sometimes confused with Methedrone (4-Methoxymethcathinone, βk-PMMC) or Methylone (βk-MDMA).

Dosage

Oral

Light: 50-100mg

Common: 100-200mg

Strong: 150-300mg

Heavy: 300mg+

Insufflated

Light: 15-25mg

Common: 20-80mg

Strong: 75-125mg

Heavy: 125mg+

Duration

Duration may lengthen with higher doses.

Oral

Onset: 15-45 minutes

Peak: 15-30 minutes

Total Duration: 2-5 hours

After-effects: 2-4 hours

Insufflated

Onset: 5-15 minutes

Peak: 15-30 minutes

Total Duration: 1-3 hours

After-effects 2-4 hours

Effects

Generally described as being more intense of a stimulant than MDMA, providing greater euphoria, but with somewhat less of an empathogenic feel and a shorter length to the 'rush.'

It is often reported as very 'fiendish,' with the tendency to cause users to redose repeatedly throughout the experience.

Postive

• Mental and physical stimulation

• Euphoria, mood lift

• Feelings of empathy, openness

• Increase in sociability, desire to talk with others

• Pleasurable rushing

Neutral

• General change in consciousness (as with most psychoactives)

• Decreased appetite

• Pupil dilation

• Unusual body sensations (facial flushing, chills, goosebumps, body energy)

• Change in body temperature regulation

• Sweating

• Increase in heart rate and blood pressure

Negative

Likelihood of negative side effects increases with higher doses

• Strong desire to redose, craving to recapture initial euphoric rush

• Uncomfortable changes in body temperature (sweating/chills)

• Heart palpitations, sense of racing heart

• Impaired short term memory

• Insomnia

• Tightened jaw muscles, grinding teeth (trismus and bruxia)

• Muscle twitching

• Nystagmus

• Dizziness, light headedness, vertigo

• Vasoconstriction

• When insufflated: pain and swelling in nose and throat, sinusitis

Harm Reduction

• Taking Mephedrone while on SSRIs or MAOIs can cause serotonin syndrome, which can be deadly.

• The drug has not been proven as neurotoxic, however primary indications show that it may well be. As this is the case, care should be taken to space experiences with this drug out - two weeks has been regarded as a good rule of thumb.

• Given the tendency for users to redose, issues such as malnutrition and sleep deprivation may become a problem with extended use. Try to sleep, and see Quick Guide to Stimulant Comedowns for more information on managing a comedown.

Chemistry and Pharmacology

Mephedrone is a releasing agent and reuptake inhibitor of dopamine, serotonin and norepinephrine.

Legal status

For a breakdown of the legal status of Mephedrone click here.

Links

https://www.erowid.org/chemicals/4_methylmethcathinone/4_methylmethcathinone.shtml