Tramadol: Difference between revisions
Trainwreck (talk | contribs) |
(→Dosage) |
||
| Line 25: | Line 25: | ||
*Other CNS depressants | *Other CNS depressants | ||
The following products may react negatively with | The following products may react negatively with tramadol and may cause overdose if mixed together. | ||
*Alcohol | *Alcohol | ||
*Diphenhydramine | *Diphenhydramine | ||
== WARNING == | == WARNING == | ||
*Tramadol effects serotonin levels in the brain. For this reason it is reccomended to taper on, and taper off use. This drug has very little potential for abuse, due to it being a WEAK opiate agonist. | *Tramadol effects serotonin levels in the brain. For this reason it is reccomended to taper on, and taper off use. This drug has very little potential for abuse, due to it being a WEAK opiate agonist. | ||
Revision as of 19:53, 25 July 2013
General Information
Classification: Opiate/Downer/Sedative/Painkiller/SNRI/Reuptake inhibitor of serotonin and of norepinephrine
Dosage
- 150mg-200mg (No tolerance)
- 200mg-250mg (Medium-High tolerance)
- 300mg-400mg (Very High tolerance, WARNING: Seizure threshold is DANGEROUSLY lowered at this point)
- 400mg+ (Extremely High tolerance, potentially fatal for new users WARNING: Seizure threshold is DANGEROUSLY lowered at this point)
Onset:
- Oral: 1-2 hours
Peak Benefit:
- Oral: 3-4 hours
Duration
- Long onset, slowly building to a peak by hour 4 with maximum blood concnetration acheived near hour 4.5
- Half-life: 5.5-7 hours
Potentiators/avoiders:
- Alcohol
- Other CNS depressants
The following products may react negatively with tramadol and may cause overdose if mixed together.
- Alcohol
- Diphenhydramine
WARNING
- Tramadol effects serotonin levels in the brain. For this reason it is reccomended to taper on, and taper off use. This drug has very little potential for abuse, due to it being a WEAK opiate agonist.
Effects
Do not drive or operate machinery while under the influence of tramadol.
Positive
- Euphoria
- Painfree
- Overall feeling of contentedness
Neutral
- Itching
Negative
Some users may experience
- Nausea
- Constipation
- CNS depression
- Drowsiness
- hot/cold flashes
- Dizziness
- Vomiting
- Urinary retention (difficulty urinating)
In high doses, overdoses, or in patients not tolerant to opiates, tramadol can cause shallow breathing, bradycardia, cold-clammy skin, apnea, hypotension, miosis, circulatory collapse, respiratory arrest, and death.
Harm Reduction
Don't take any more tramadol than you are prescribed.
By itself, it can decrease the seizure threshold. When combined with SSRIs, tricyclic antidepressants, or in patients with epilepsy, the seizure threshold is further decreased. Seizures have been reported in humans receiving excessive single oral doses (700 mg) or large intravenous doses (300 mg). However, there have been several rare cases of people having grand-mal seizures at doses as low as 100–400 mg orally.
Do not consume alcohol or other drugs while under the influence of Tramadol