Benzodiazepines

General Information

Classification: Downer/Sedative/Anxiolytic

Dosage

Comparison of benzodiazepines

Chemical name (brand name)	Half-Life [Active Metabolites]	Dose Equiv. of 10mg Diazepam (Oral)	Class
Alprazolam (Xanax)	6 - 12 hours	0.5 mg	Anxiolytic
Bromazepam (Lexotan, Lexomil)	10 - 20 hours	5 - 6 mg	Anxiolytic
Chlordazepoxide (Librium)	5 - 30 hours [36 - 200 hours]	25 mg	Anxiolytic
Clobazam (Frisium)	12 - 60 hours	20 mg	Anxiolytic
Clonazepam (Klonopin)	18 - 50 hours	0.5 mg	Anxiolytic
Clorazepate (Tranxene)	[36 - 200 hours]	15 mg	Anxiolytic
Diazepam (Valium)	20 - 100 hours [36 - 200 hours]	10 mg	Anxiolytic
Estazolam (ProSom, Nuctalon)	10 - 24 hours	1 - 2 mg	Hypnotic
Flunitrazepam (Rohypnol)	18 - 26 hours [36 - 200 hours]	1 mg	Hypnotic
Flurazepam (Dalmane)	[40 - 250 hours]	15 - 30 mg	Hypnotic
Halazepam (Paxipam)	[30 - 100 hours]	20 mg	Anxiolytic
Ketazolam (Paxipam)	30 - 100 hours [36 - 200 hours]	15 - 30 mg	Anxiolytic
Loprazolam (Dormonoct)	6 - 12 hours	1 - 2 mg	Hypnotic
Lorazepam (Ativan)	10 - 20 hours	1 mg	Anxiolytic
Lormetazepam (Noctamid)	10 - 12 hours	1 - 2 mg	Hypnotic
Medazepam (Nobrium)	36 - 200 hours	10 mg	Anxiolytic
Nitrazepam (Mogadon)	15 - 38 hours	10 mg	Hypnotic
Nordazepam (Nordaz)	36 - 200 hours	10 mg	Anxiolytic
Oxazepam (Serax)	4 - 15 hours	20 mg	Anxiolytic
Prazepam (Centrax)	[36 - 200 hours]	10 - 20 mg	Anxiolytic
Quazepam (Doral)	25 - 100 hours	20 mg	Hypnotic
Temazepam (Restoril)	8 - 22 hours	20 mg	Hypnotic
Triazolam (Halcion)	2 hours	0.5 mg	Hypnotic

Non-benzodiazepines commonly referred to as Z-drugs

Chemical name (brand name)	Half-Life [Active Metabolites]	Dose Equiv. of 10mg Diazepam (Oral)	Class
Zaleplon (Sonata)	2 hours	20 mg	Hypnotic
Zolpidem (Ambien)	2 hours	20 mg	Hypnotic
Zopiclone (Imovane)	5 - 6 hours	15 mg	Hypnotic
Eszopiclone (Lunesta)	6 hours	3 mg	Hypnotic

Oral

Onset:

Alprazolam IR : 8-25 minutes

Alprazolam XR : 25-75 minutes

Diazepam : Rapid

Clonazapam : 1 hour

Lorazepam : 1-2 hours

Peak Benefit:

Diazepam : 1.6 hours

Alprazolam IR : 90 minutes

Alprazolam XR : 25-75 minutes

Diazepam : 2-4 hours

Clonazapam : 1-4 hours

Half/Life and Duration

Triazolam : 2.5 Hours

Lorazepam : 10-20 hours - 6-12 hour duration

Alprazolam IR : 11 hour half life - 5 hour duration

Alprazolam XR :11-16 hour hour half life, 11 hour duration

Diazepam : 20-100 hour half life - 6-8 hour duration

Clonazepam : 18-50 hour half life - 12+ hours

Dosages Depend on tolerance.

Potentiators:

-Grapefruit juice

Avoid:

-Excessive drinking (you will die)

Smoked

Duration: X hours

Onset: X minutes

Low dose: X mg

Medium (typical) dose: X mg

High dose: X mg

Insufflated

NOT RECOMMENDED

Duration: X hours

Onset: X minutes

Low dose: X mg

Medium (typical) dose: X mg

High dose: X mg

Injected

NOT RECOMMENDED

Duration: X hours

Onset: X minutes

Low dose: X mg

Medium (typical) dose: X mg

High dose: X mg

Effects

Positive

• Stress Relief
• Anxiety Relief
• Social Anxiety
• PTSD
• Sedative
• Worries drift away
• That "sink into the couch" feeling

Negative

• High addiction potential
• Killer withdrawals
• Risk of blackout
• Inability to drink
• Inability to dirve
• Loss of balance
• Memory Loss
• Procrastination

After effects

• "Hangover"?

• Afterglow

• Long term effects

• High addiction potential

Harm Reduction

• Avoid driving and operating heavy machinery

• Recommended time (pauses) between using the substance

• Addiction potential - High

• Risk of blackouts

• Risk of death when mixed with alcohol

• Mental illness?

• Heart issues?

• CNS depressant when mixed with other drugs

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