Methoxetamine

General Information

Methoxamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of Ketamine and PCP. It was first publicly reported in 2010. Some say it's similar to Ketamine or a high dose DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor. The N-Ethyl group on this compound increases potency.

Dosage

Oral

Threshold: 5-20mg

Low: 10-30mg

Common: 40-60mg

Strong: 50-100mg+

Insufflated

Threshold: 5-15mg

Low: 15-30mg

Medium: 30-50mg

Strong: 50-75mg

Hole: 75-100mg+

Sublingual

Threshold: 5-10mg

Low: 10-25mg

Medium: 40-60mg

Strong: 60-75mg

Hole: 75-100mg

Duration

Oral

Onset: 30-60 minutes

Total duration: 3-6 hours

After effects (depends on dose): 2-48 hours

Insufflated

Onst: 5-20 minutes

Total duration: 3-6 hours

After effects (depends on dose): 2-48 hours

Sublingual

Onset: 15-45 minutes

Total duration: 3-6 hours

After effects (depends on dose): 2-48 hours

Effects

Positive

• Euphoria, mood lift
• Sense of calm and serenity
• Vivid recall of past memories and dreams
• Closed- and open-eye visuals (common)
• Out-of-body experience (less intense then ketamine)

Neutral

• Distortion or loss of sensory perceptions (common)
• Dissociation of mind from body
• Sweating
• Analgesia, numbness
• Significant change in perception of time
• Increase in heart rate
• Confusion, disorientation

Negative

• Risk of psychological dependency
• Nasal discomfort upon insufflation
• Blacking out and forgetting one has taken a drug
• Discomfort, pain or numbness at injection site (with IM)
• Severe confusion, disorganised thinking
• Vertigo, spinning sensation (risk of injury)
• Nausea, vomiting
• Susceptibility to accidents (from uncoordination and change in perception of body and time)
• Severe dissociation, depersonalisation
• Loss of consciousness
• Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)

Harm Reduction

• Avoid driving at all costs.
• Avoid walking or moving around in general if you are on a medium to hole dose.
• Taking this on a non-empty substance could lead to nausea.

Interactions

Drug Combinations

Links

Wikipedia

Erowid

Drugs-Forum

/r/Drugs FAQ