Tramadol: Difference between revisions
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==Duration== | ==Duration== | ||
Long onset, slowly building to a peak by hour 4 with maximum blood concentration achieved near hour 4.5 | Long onset, slowly building to a peak by hour 4 with maximum blood concentration achieved near hour 4.5. | ||
Onset: 1-2 hours | Onset: 1-2 hours | ||
Revision as of 19:34, 16 March 2014
General Information
Classification: Depressant Tramadol is a sedative and a painkiller
Dosage
No tolerance: 150mg-200mg
Medium-High tolerance: 200mg-250mg
Very High tolerance: 300mg-400mg (Seizure threshold is DANGEROUSLY lowered at this point)
Extremely High tolerance: 400mg+ (potentially fatal for new users. Seizure threshold is DANGEROUSLY lowered at this point)
Duration
Long onset, slowly building to a peak by hour 4 with maximum blood concentration achieved near hour 4.5.
Onset: 1-2 hours
Peak: 3-4 hours
Total Duration: 5-7 hours
Effects
Positive
- Euphoria
- Pain relief
- Elevated mood
- Overall feeling of contentedness
Neutral
- Itching
Negative
Some users may experience
- Nausea
- Constipation
- CNS depression
- Drowsiness
- hot/cold flashes
- Dizziness
- Vomiting
- Urinary retention (difficulty urinating)
In high doses, overdoses, or in patients not tolerant to opiates, tramadol can cause shallow breathing, bradycardia, cold-clammy skin, apnea, hypotension, miosis, circulatory collapse, respiratory arrest, and death.
Potentiators
- Alcohol
- Other CNS depressants
WARNING
Tramadol effects serotonin levels in the brain. For this reason it is reccomended to taper on, and taper off use. This drug has very little potential for abuse, due to it being a WEAK opiate agonist.
The following products may react negatively with tramadol and may cause overdose if mixed together.
- Alcohol
- Diphenhydramine
Chemistry and Pharmacology
SNRI Reuptake inhibitor of serotonin and of norepinephrine
Harm Reduction
Don't take any more tramadol than you are prescribed.
Do not drive or operate machinery while under the influence of tramadol.
We cannot stress this enough. If you have a history of seizures, we strongly urge you to stay away from tramadol as a recreational substance.
By itself, it can decrease the seizure threshold. When combined with SSRIs, tricyclic antidepressants, or in patients with epilepsy, the seizure threshold is further decreased. Seizures have been reported in humans receiving excessive single oral doses (700 mg) or large intravenous doses (300 mg). However, there have been several rare cases of people having grand-mal seizures at doses as low as 100–400 mg orally.
Do not consume alcohol or other drugs while under the influence of Tramadol