Clonazolam

Clonazolam (also known as Clonitrazolam) is a novel psychoactive class::depressant substance of the chemical class::benzodiazepine chemical class which produces anxiolytic, sedative, muscle relaxant, and amnesic effects when administered. This compound is a novel research chemical derivative of the FDA-approved drugs clonazepam (Klonopin, Rivitrol) and alprazolam (Xanax). Clonazolam is reported to be roughly 2.5x as potent as alprazolam.

History

The synthesis of clonazolam was first reported in 1971. It was described as the most active compound in the series tested.

Very little is known about this substance, but it has recently become easily accessible through online research chemical vendors where it is being sold as a designer drug.

Usage

Ritual use, different types of administration and how to do it, etc.

Dosage

General note/warning about dosage

Oral

Threshold	50-75ug
Light	75-200ug
Common	200-400ug
Strong	500-1000ug

Duration

Oral

Onset	10-30 minutes
Total	6-10 hours
After-effects	1-12 hours (dose-dependent)

Effects

Postive

• effect

Neutral

• effect

Negative

• effect

Images

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  Example image 1

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  Example image with link: TripSit Rules

Harm Reduction

Clonazolam is reputed to be highly potent, and concerns have been raised that it and flubromazolam may pose comparatively higher risks than other designer benzodiazepines due to their ability to produce strong sedation and amnesia at oral doses as low as 0.5 mg, or 500 micrograms (ug). It is reported to have a medium-length onset of action (20 - 60 minutes).

• warning 1

• warning 2

WARNING

Due to its extremely high potency, it is often found on blotter paper or in volumetrically dosed solutions. Ingestion of raw clonazolam powder is unsafe due to its microgram-range potency and the ease in which it can lead to multi-day blackouts.

Potentiators

• substance 1

• substance 2

Interactions

Check out our Drug Combinations page and chart for interactions and combinations of common drugs.

• All other CNS depressants.

Chemistry and Pharmacology

Clonazolam is a drug of the benzodiazepine class. Benzodiazepine drugs contain a benzene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R₁ and R₄. The benzyl ring of clonazolam is substituted at R₈ with a nitro group, NO₂-. Further, the diazepine ring is bonded at R₆ to a 2-chlorinated phenyl ring.

Clonazolam also contains a 1-methylated triazole ring fused to and incorporating R₁ and R₂ of its diazepine ring. Clonazolam belongs to a class of benzodiazepines containing this fused triazole ring, called triazolobenzodiazepines, distinguished by the suffix "-zolam." Clonazolam is also a nitrobenzodiazepine, a subclass of benzodiazepines which contain a nitro (NO₂-) group. Other nitrobenzodiazepines include clonazepam and flunitrazepam.

Legal status

• USA: Unscheduled
• UK: Class C