Methoxetamine: Difference between revisions

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Methoxetamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor (SRI). The N-Ethyl group on this compound increases potency.
[[File:Mxe.jpg|200px|left]]
'''Methoxetamine''' (MXE, 3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor (SRI). The N-Ethyl group on this compound increases potency.


= Dosage =
== Dosage ==


{| class="wikitable"
{{#tdose: mxe }}
|+ Oral
|-
| Threshold || 5-20mg
|-
| Low || 10-30mg
|-
| Common || 40-60mg
|-
| Strong || 50-100mg+
|}


{| class="wikitable"
== Duration ==
|+ Insufflated
|-
| Threshold || 5-15mg
|-
| Low || 15-30mg
|-
| Common || 30-50mg
|-
| Strong || 50-75mg
|-
| Hole || 75-100mg+
|}
 
{| class="wikitable"
|+ Sublingual
|-
| Threshold || 5-10mg
|-
| Low || 10-20mg
|-
| Common || 40-60mg
|-
| Strong || 60-75mg
|-
| Hole || 75-100mg+
|}
 
= Duration =


{| class="wikitable"
{| class="wikitable"
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|}
|}


= Effects =
== Effects ==


== Positive ==
=== Positive ===
* Euphoria, mood lift
* Euphoria, mood lift
* Sense of calm and serenity
* Sense of calm and serenity
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* Out-of-body experience (less intense then ketamine)
* Out-of-body experience (less intense then ketamine)


== Neutral ==
=== Neutral ===
* Distortion or loss of sensory perceptions (common)
* Distortion or loss of sensory perceptions (common)
* Dissociation of mind from body
* Dissociation of mind from body
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* Confusion, disorientation
* Confusion, disorientation


== Negative ==
=== Negative ===
* Risk of psychological dependency
* Risk of psychological dependency
* Nasal discomfort upon insufflation
* Nasal discomfort upon insufflation
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* Loss of consciousness
* Loss of consciousness
* Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)
* Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)
* Entity contact
== Harm Reduction ==
A recent [https://www.ncbi.nlm.nih.gov/pubmed/30377924 study] on rats indicates that MXE may have harmful effects on the cardiovascular system, and therefor should probably be avoided by anyone with any history of cardiovascular issues.


= Harm Reduction =
See [[Dissociatives#Harm_Reduction|Dissociative Harm Reduction]] for general information.
* Avoid driving at all costs.
* Avoid walking or moving around in general if you are on a medium to hole dose.
* Taking this on a non-empty substance could lead to nausea.


== Interactions ==
=== Interactions ===
MXE is extremely dangerous in combination with alcohol and can cause fatal apnea or respiratory depression.
Even residual MXE can potentiate the effects of 5ht agonists.
[[Drug Combinations]]
[[Drug Combinations]]


= Chemistry and Pharmacology =
== Chemistry and Pharmacology ==


Examination of MXE molecule showed that, similar to [[Ketamine]], the 2 isomers have totally different effects with the (S) having potent NMDA activity (when the -OCH3 is deprotected to -OH, it gets stronger) while the (R) isomer has SRI effects and possibly a opioid metabolite.
Examination of MXE molecule showed that, similar to [[Ketamine]], the 2 isomers have totally different effects with the (S) having potent NMDA activity (when the -OCH3 is deprotected to -OH, it gets stronger) while the (R) isomer has SRI effects and possibly a opioid metabolite.
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MXE is generally sold racemic.
MXE is generally sold racemic.


= Legal status=
== Legal status==


Methoxetamine is illegal in the US states Arizona<ref>http://www.azleg.gov/DocumentsForBill.asp?Session_ID=112&Bill_Number=HB2453</ref>, Florida<ref>http://www.leg.state.fl.us/Statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html</ref>, Indiana<ref>http://www.in.gov/legislative/ic/2010/title35/ar31.5/ch2.html</ref>, Louisiana<ref>http://www.legis.la.gov/legis/ViewDocument.aspx?d=850979&n=HB10%20Act</ref>, Minnesota<ref>https://www.revisor.mn.gov/statutes/?id=152.02</ref>, North Dakota<ref>http://www.legis.nd.gov/cencode/t19c03-1.pdf?20140721032549</ref>, Ohio<ref>http://www.legislature.state.oh.us/BillText130/130_HB_315_RH_N.html</ref> and Virginia<ref>http://lis.virginia.gov/cgi-bin/legp604.exe?000+cod+54.1-3446</ref>. It is also banned in Brazil, France, Germany, Japan, Russia and the UK<ref>http://www.legislation.gov.uk/uksi/2013/239/contents/made</ref>.  
Methoxetamine is illegal in the US states Arizona<ref>http://www.azleg.gov/DocumentsForBill.asp?Session_ID=112&Bill_Number=HB2453</ref>, Florida<ref>http://www.leg.state.fl.us/Statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html</ref>, Indiana<ref>http://www.in.gov/legislative/ic/2010/title35/ar31.5/ch2.html</ref>, Louisiana<ref>http://www.legis.la.gov/legis/ViewDocument.aspx?d=850979&n=HB10%20Act</ref>, Minnesota<ref>https://www.revisor.mn.gov/statutes/?id=152.02</ref>, North Dakota<ref>http://www.legis.nd.gov/cencode/t19c03-1.pdf?20140721032549</ref>, Ohio<ref>http://www.legislature.state.oh.us/BillText130/130_HB_315_RH_N.html</ref> and Virginia<ref>http://lis.virginia.gov/cgi-bin/legp604.exe?000+cod+54.1-3446</ref>. It is also banned in Brazil, France, Germany, Japan, Russia and the UK<ref>http://www.legislation.gov.uk/uksi/2013/239/contents/made</ref>.  


= Links =  
== Links ==  


[https://en.wikipedia.org/wiki/Methoxetamine Wikipedia]
[https://en.wikipedia.org/wiki/Methoxetamine Wikipedia]
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[http://reddit.com/r/Drugs/comments/o9wam/rdrugs_ama_series_mxe_methoxetamine/?sort=top /r/Drugs FAQ]
[http://reddit.com/r/Drugs/comments/o9wam/rdrugs_ama_series_mxe_methoxetamine/?sort=top /r/Drugs FAQ]


= References =
== References ==


<references />
<references />
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[[Category:Drugs]]
[[Category:Drugs]]
[[Category:Dissociative]]
[[Category:Dissociative]]
[[Category:Research Chemical]]

Latest revision as of 09:12, 7 November 2018

Methoxetamine (MXE, 3-MeO-2-Oxo-PCE) is a near chemical analogue of Ketamine and PCP. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor (SRI). The N-Ethyl group on this compound increases potency.

Dosage

{{#tdose: mxe }}

Duration

Oral
Onset 30-60 minutes
Total 3-6 hours
After-effects 2-48 hours (dose-dependent)
Insufflated
Onset 5-40 minutes
Total 3-6 hours
After-effects 2-48 hours (dose-dependent)
Sublingual
Onset 15-45 minutes
Total 3-6 hours
After-effects 2-48 hours (dose-dependent)

Effects

Positive

  • Euphoria, mood lift
  • Sense of calm and serenity
  • Vivid recall of past memories and dreams
  • Closed- and open-eye visuals (common)
  • Out-of-body experience (less intense then ketamine)

Neutral

  • Distortion or loss of sensory perceptions (common)
  • Dissociation of mind from body
  • Sweating
  • Analgesia, numbness
  • Significant change in perception of time
  • Increase in heart rate
  • Confusion, disorientation

Negative

  • Risk of psychological dependency
  • Nasal discomfort upon insufflation
  • Blacking out and forgetting one has taken a drug
  • Discomfort, pain or numbness at injection site (with IM)
  • Severe confusion, disorganised thinking
  • Vertigo, spinning sensation (risk of injury)
  • Nausea, vomiting
  • Susceptibility to accidents (from uncoordination and change in perception of body and time)
  • Severe dissociation, depersonalisation
  • Loss of consciousness
  • Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)
  • Entity contact

Harm Reduction

A recent study on rats indicates that MXE may have harmful effects on the cardiovascular system, and therefor should probably be avoided by anyone with any history of cardiovascular issues.

See Dissociative Harm Reduction for general information.

Interactions

MXE is extremely dangerous in combination with alcohol and can cause fatal apnea or respiratory depression. Even residual MXE can potentiate the effects of 5ht agonists. Drug Combinations

Chemistry and Pharmacology

Examination of MXE molecule showed that, similar to Ketamine, the 2 isomers have totally different effects with the (S) having potent NMDA activity (when the -OCH3 is deprotected to -OH, it gets stronger) while the (R) isomer has SRI effects and possibly a opioid metabolite.

MXE is generally sold racemic.

Legal status

Methoxetamine is illegal in the US states Arizona[1], Florida[2], Indiana[3], Louisiana[4], Minnesota[5], North Dakota[6], Ohio[7] and Virginia[8]. It is also banned in Brazil, France, Germany, Japan, Russia and the UK[9].

Links

Wikipedia

Erowid

Drugs-Forum

/r/Drugs FAQ

References

  1. ↑ http://www.azleg.gov/DocumentsForBill.asp?Session_ID=112&Bill_Number=HB2453
  2. ↑ http://www.leg.state.fl.us/Statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html
  3. ↑ http://www.in.gov/legislative/ic/2010/title35/ar31.5/ch2.html
  4. ↑ http://www.legis.la.gov/legis/ViewDocument.aspx?d=850979&n=HB10%20Act
  5. ↑ https://www.revisor.mn.gov/statutes/?id=152.02
  6. ↑ http://www.legis.nd.gov/cencode/t19c03-1.pdf?20140721032549
  7. ↑ http://www.legislature.state.oh.us/BillText130/130_HB_315_RH_N.html
  8. ↑ http://lis.virginia.gov/cgi-bin/legp604.exe?000+cod+54.1-3446
  9. ↑ http://www.legislation.gov.uk/uksi/2013/239/contents/made
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