Terminology

MXE

Methoxetamine

Agonist

agonist

A substance that initiates a physiological response when combined with a receptor.

Antagonist

antagonist

A substance that interferes with or inhibits the physiological action of another.

Cannabinoid

cannabinoid

Chemicals produced naturally that bind to cannabinoid receptors. They are involved in a variety of mental and physical processes, including pain regulation, food intake, and reward.

CNS

Central Nervous System

Cathinone

cathinone

Cathinone, or Benzoylethanamine is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine and other amphetamines. Cathinone differs from amphetamine by possessing a ketone oxygen atom on the β position of the side chain.

Chiral

chiral

The term chiral describes an object, especially a molecule, which has or produces a non-superimposeable mirror image of itself.

Dopamine

dopamine

A neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system.

Enantiomer

enantiomer

One of two stereoisomers that are mirror images of each other that are non-superposable (not identical). Think of it like the left and right hand, which are identical aside from orientation.

GABA

Gamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter.

LD50

ld50

The dosage of a substance at which 50% of the exposed subjects does not survive. To estimate the LD50 for humans, tests are conducted on non-human subjects.

MAO

Monoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).

MAOI

Monoamine oxidase inhibitor are drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate.

Nootropic

nootropic

Nootropics, also referred to as smart drugs, memory enhancers, neuro enhancers, cognitive enhancers, and intelligence enhancers, are drugs, supplements, nutraceuticals, and functional foods that purportedly improve mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. They are generally neuroprotective, and non-toxic.

Norepinephrine

Norepinephrine, or noradrenaline, is a catecholamine with multiple roles including as a hormone and a neurotransmitter.

Phenethylamine

phenethylamine

Phenethylamine (PEA) is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. In the mammalian central nervous system, phenethylamine is believed to function as a neuromodulator or neurotransmitter.

Releaser

releaser

A releasing agent (RA), or simply releaser, is a drug that induces the release of a neurotransmitter from the presynaptic neuron into the synapse, leading to an increase in the extracellular concentrations of the neurotransmitter.

Serotonin

serotonin

A monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being.

ROA

Common abbreviation for Route Of Administration, used to describe the various different methods of ingesting drugs, including oral, insufflation, sublingual/buccal, rectal, vaginal, intramuscular (IM) and intravenous (IV) injection.

Bioavailability

bioavailability

The fraction of an administered dose that is absorbed into a living system.

Oral administration

oral administration

orally

Route of administration in which the subject swallows a substance.

Sublingual administration

sublingual administration

sublingually

Route of administration in which the subject places a substance under the tongue.

Buccal administration

buccal administration

buccally

Route of administration in which the subject places a substance against their gums or other oral mucosa.

Isomer

isomer

Each of two or more compounds with the same formula but a different arrangement of atoms in the molecule and different properties.

DRI

Dopamine Reuptake Inhibitor

SRI

Serotonin Reuptake Inhibitor

NDRI

Norepinephrine-Dopamine Reuptake Inhibitor

SSRI

Selective Serotonin Reuptake Inhibitor

SNRI

Serotonin–Norepinephrine Reuptake Inhibitor

SNDRI

TRI

Serotonin–Norepinephrine–Dopamine Reuptake Inhibitor

SARI

Serotonin Antagonist and Reuptake Inhibitor

TCA

Tricyclic Antidepressant

TeCA

Tetracyclic Antidepressant

NMDA

N-methyl-D-aspartate receptor. NMDA antagonists are often dissociatives.

TAAR

Trace amine-associated receptor

Bruxism

Bruxing

bruxing

Grinding or clenching of the teeth

Ataxia

ataxia

Loss of motor coordination

Pyrrolidine

pyrrolidine

Amphetamines with a pyrrolidine group.

Pyrrolidinophenone

pyrrolidinophenone

Pyrovalerones or Pyrrolidinophenones are Cathinones (βk-Amphetamines) with a pyrrolidine group.

Steroid

steroid

Anabolic steroids are drugs that are structurally related to the cyclic steroid ring system and have similar effects to testosterone in the body. They increase protein within cells, especially in skeletal muscles. Anabolic steroids also have androgenic and virilizing properties, including the development and maintenance of masculine characteristics such as the growth of the vocal cords, testicles (primary sexual characteristics) and body hair (secondary sexual characteristics).

SARM

Selective androgen receptor modulators or SARMs are a novel class of androgen receptor ligands. They are intended to have the same kind of effects as androgenic drugs like anabolic steroids but be much more selective in their action, allowing them to be used for many more clinical indications than the relatively limited legitimate uses that anabolic steroids are currently approved for.

Arylcyclohexylamine

arylcyclohexylamine

A class of dissociatives, which includes PCP, Ketamine, Methoxetamine and others. An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary, secondary amines such as methylamino or ethylamino, or tertiary cycloalkylamines such as piperidino and pyrrolidino, are the most commonly encountered N-substituents.

Diarylethylamine

diarylethylamine

A novel class of drugs, includes Diphenidine, Lefetamine, MT-45 and others.

Thienodiazepine

thienodiazepine

Close analogues of benzodiazepines.

NBOMe

NBOMes

N-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines.

NBOH

NBOHs

N-Benzyl-HydrOxy derivatives of psychedelic phenethylamines.

NBF

N-Benzyl-Fluoro derivatives of psychedelic phenethylamines.

DALT

Diallyltryptamine

DET

Diethyltryptamine

DPT

Dipropyltryptamine

DiPT

Diisopropyltryptamine

EiPT

Ethylisopropyltryptamine

MET

Methylethyltryptamine

MiPT

Methylisopropyltryptamine

THC

Tetrahydrocannabinol

CBD

Cannabidiol

Lethargy

lethargy

A lack of energy and enthusiasm.

Blepharospasm

blepharospasm

Involuntary eye twitching.