Diphenidine

Diphenidine (1-(1,2-diphenylethyl)piperidine) is a dissociative anesthetic drug.

History

The first synthesis of diphenidine was published in 1924 by Christiaen who used a modified Brulyants reaction, similar to the reaction later used by Maddox in the first PCP synthesis.

While diphenidine was never used or investigated medically, several related compounds have been and include the withdrawn analgesic lefetamine and investigational compounds such as AstraZenica’s NMDA antagonist antidepressant Lanicemine, and neurodegenerative disease and anti-epileptic agent Remacemide.

Shortly after the UK arylcyclohexylamine ban in early 2013, diphenidine and its 2-MeO derivative methoxphenidine emerged on the RC market.

Dosage

Diphenidine can also be insufflated, vaporized and injected. Start with low doses and work your way up.

{{#tdose: diphenidine }}

Duration

Oral

Onset	15-30 minutes
Total	2-5 hours
After-effects	4-24 hours

Effects

Postive

• Stimulation
• Euphoria
• Disconnected thoughts
• Shifts in perception of reality

Neutral

• Altered time perception
• Disrupted speech patterns
• Distorted sensory perceptions, hallucinations
• Confusion

Negative

• Severe dissociation, depersonalization
• Ataxia (loss of motor coordination)
• Temporary amnesia

Harm Reduction

See Dissociative Harm Reduction for general information.

Potentiators

• CNS depressants

Interactions

It is currently unknown whether diphenidine is a reuptake inhibitor of serotonin (SRI), if that is the case do NOT ever combine it with other SRIs (such as MXE) or SSRIs.

Check out our Drug Combinations page and chart for interactions and combinations of common drugs.

Chemistry and Pharmacology

Diphenidine is a NMDA antagonist and possibly a reuptake inhibitor of serotonin or dopamine.

Legal status

Diphenidine is, as of July 2014, not a controlled substance in any country.

Links

• Bluelight Big & Dandy thread
• From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.