5-MeO-DMT: Difference between revisions

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[[File:Bufo-alvarius.jpg|250px|right]]
'''5-MeO-DMT''' was first discovered in ''Dictyoloma incanescens'' and later was isolated from ''Anadenanthera peregrina'' as well. It occurs in a very large number of plants, often in association with [[N,N-DMT]]. Its effects are somewhat more potent than those of N,N-DMT. When the two are administered simultaneously, 5-MeO-DMT more quickly occupies the specific receptors. 5-MeO-DMT is a natural neurotransmitter in the human nervous system. When 5-MeO-DMT (10 to 20 mg) is smoked or vaporized and inhaled, the effects are almost immediately apparent, are incredibly extreme, and last about ten minutes. Many people report having shamanic experiences with this substance as well as experiencing states of enlightenment and the clear light of nirvana (Metzner 1988). The Colorado River toad (''Bufo alvarius'') is native to the area around Tucson, Arizona. These toads spend nine months of the year underground, buried in the mud that keeps them protected from the burning desert sun. The toads emerge from their hiding places with the first rains and begin their courtship (Smith 1982,97-100). They remain visible for only three months. Like all toads, Bufo alvarius develops mucous secretions in two glands that are located on the neck The secretions of the Colorado River toad, however, do not contain bufotoxine, the toxic substance that is found in the secretions of most other toads. Instead, the dried mass contains 15% 5-MeO-DMT (Erspamer et al. 1965, 1967). The native tribes that lived in the North American Southwest made fetishes of this Bufo alvarius. However, it was only in recent times that the toad's cultural importance and its psychedelic use were discovered, or more likely rediscovered (cf. Davis and Weil 1992). The toad is "milked" by being held firmly without being crushed. Both glands are then massaged gently until a fat stream of the secretion squirts out. The secretion is caught on a piece of glass, where it is allowed to dry and crystallize. The yellowish crystalline mass then can be scraped off, mixed with different herbs (such as damiana [Turnera diffusa] ), and smoked. The toad, which is released unharmed, is quickly able to replenish the loss in its secretions. When taken orally, Bufo alvarius secretions are apparently toxic, whereas they are not poisonous when smoked (Weil and Davis 1994). Davis and Weil have suggested that the dried secretions of Bufo alvarius were traded to Mexico in preColumbian times and that the priests and shamans there smoked or used it in some other manner (Davis and Weil1992; cf. balche', bufotenine). In Arizona, there is now a Church of the Toad of Light, which uses the secretions of Bufo alvarius as a sacrament (Most 1984; Ott 1993,396*).


<table style="font-family: Arial, Helvetica, sans-serif; font-size: 9pt;" width="100%" border="0" cellspacing="0" cellpadding="0">
== Dosage ==
{| class="wikitable"
|+ Smoked/Vaporized
|-
| Light || 2-5 mg
|-
| Common || 5-10 mg
|-
| Strong || 10-20 mg
|}


<tr>
{| class="wikitable"
<td valign="top" width="50%"><strong>Other Names</strong>
|+ Insufflated
|-
| Light || 3-5 mg
|-
| Common || 5-10 mg
|-
| Strong || 8-15 mg
|}


Dimethyl-5-methoxytryptamine, 5-methoxy-DMT,
== Duration ==


5-methoxy-N,N-dimethyl-tryptamine, 0-methylbufotenine,
{| class="wikitable"
|+ Smoked/Vaporized
|-
| Onset || 0-1 minutes
|-
| Total || 5-15 hours
|-
| After-effects || 15-60 hours (dose-dependent)
|}


3- [2-(dimethylamino)ethyl] -5-methoxy-
{| class="wikitable"
|+ Insufflated
|-
| Onset || 1-5 minutes
|-
| Total || 15-45 hours
|-
| After-effects || 1-3 hours (dose-dependent)
|}


indole, toad foam
== Effects ==
=== Postive ===


Substance type: tryptamine (indole alkaloid)
*Immersive experiences
*Profound life-changing spiritual experiences
*Occasional euphoria
*Sensual enhancement


5-MeO-DMT was first discovered in Dictyoloma
=== Neutral ===


incanescens DC. and later was isolated from Anadenanthera
*Short Duration
*Abnormal vocalizations
*Dissociation
*Muscle jerking


peregrina as well. It occurs in a very
=== Negative ===


large number of plants, often in association with
*Fear
*Panic
*Overly-intense experiences
*Hard on the lungs to smoke


N,N-DMT (see the table on pages 853-854). Its
== Harm Reduction ==
=== Interactions ===
Check out our [[Drug Combinations]] page and chart for interactions and combinations of common drugs.


effects are somewhat more potent than those of
== Chemistry and Pharmacology ==


N,N-DMT. When the two are administered simultaneously,
=== LD50 ===
115 mg/kg in mice


5-MeO-DMT more quickly occupies
== Links ==
 
[https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml Erowid]
the specific receptors. 5-MeO-DMT is a natural
 
neurotransmitter in the human nervous system.
 
When 5-MeO-DMT (10 to 20 mg) is smoked or
 
vaporized and inhaled, the effects are almost
 
immediately apparent, are incredibly extreme, and
 
last about ten minutes. Many people report having
 
shamanic experiences with this substance as well
 
as experiencing states of enlightenment and the
 
clear light of nirvana (Metzner 1988).
 
The Colorado River toad (Bufo alvarius) is
 
native to the area around Tucson, Arizona. These
 
toads spend nine months of the year underground,
 
buried in the mud that keeps them protected from
 
the burning desert sun. The toads emerge from
 
their hiding places with the first rains and begin
 
their courtship (Smith 1982,97-100). They remain
 
visible for only three months. Like all toads, Bufo
 
alvarius develops mucous secretions in two glands
 
that are located on the neck The secretions of the
 
Colorado River toad, however, do not contain
 
bufotoxine, the toxic substance that is found in the
 
secretions of most other toads. Instead, the dried
 
mass contains 15% 5-MeO-DMT (Erspamer et al.
 
1965, 1967).
 
The native tribes that lived in the North
 
American Southwest made fetishes of this Bufo
 
alvarius. However, it was only in recent times that
 
the toad's cultural importance and its psychedelic
 
use were discovered, or more likely rediscovered
 
(cf. Davis and Weil 1992). The toad is "milked" by
 
being held firmly without being crushed. Both
 
glands are then massaged gently until a fat stream
 
of the secretion squirts out. The secretion is
 
caught on a piece of glass, where it is allowed to
 
dry and crystallize. The yellowish crystalline mass
 
then can be scraped off, mixed with different herbs
 
(such as damiana [Turnera diffusa] ), and smoked.
 
The toad, which is released unharmed, is quickly
 
able to replenish the loss in its secretions.
 
When taken orally, Bufo alvarius secretions are
 
apparently toxic, whereas they are not poisonous
 
when smoked (Wei! and Davis 1994). Davis and
 
Weil have suggested that the dried secretions of
 
Bufo alvarius were traded to Mexico in preColumbian
 
times and that the priests and shamans
 
there smoked or used it in some other manner
 
(Davis and Weil1992; cf. balche', bufotenine).
 
In Arizona, there is now a Church of the Toad
 
of Light, which uses the secretions of Bufo alvarius
 
as a sacrament (Most 1984; Ott 1993,396*).</td>
<td valign="top" width="53%"><strong>Commercial Forms and Regulations</strong>
 
Pure 5-MeO-DMT is available from chemical
 
suppliers. While the substance is not explicitly
 
mentioned in the narcotics laws, the fact that it
 
could be interpreted as a DMT analog may result
 
in problems with the law.
 
<strong>Literature</strong>
 
See also the entries for bufotenine.
 
Davis, Wade, and Andrew T. Wei!. 1992. Identity of a
 
New World psychoactive toad. Ancient
 
Mesoamerica 3:51-59.
 
Erspamer, v., T. Vitali, M. Roseghini, and J. M. Cei.
 
1965. 5-methoxy and 5-hydroxyindolalkylamines
 
in the skin of Bufo alvarius.
 
Experientia 21:504.
 
---.1967. 5-methoxy- and 5-hydroxyindoles in
 
the skin of Bufo alvarius. Biochemical
 
Pharmacology 16:1149-64.
 
Metzner, Ralph. 1988. Hallucinogens in
 
contemporary North American shamanic
 
practice. In Proceedings ofthe Fourth
 
International Conference on the Study of
 
Shamanism and Alternate Modes ofHealing
 
(Independent Scholars of Asia), 170-75.
 
Most, A. 1984. Bufo alvarius: The psychedelic toad of
 
the Sonoran Desert. Denton, Texas: Venom Press.
 
Witsch, Christian. 1993. Die Krbtenmutter. In
 
Naturverehrung und Heilkunst, ed. C. R~itsch,
 
125-28. Sudergellersen: Bruno Martin.
 
Smith, Robert 1. 1982. Venomous animals ofArizona.
 
Bulletin 8245. Tucson: The University of Arizona.
 
Weil, Andrew T., and Wade Davis. 1994. Bufo
 
alvarius: A potent hallucinogen of animal origin.
 
Journal ofEthnopharmacology 41: 1-8.</td>
</tr>
 
</table>


[http://en.wikipedia.org/wiki/5-MeO-DMT Wikipedia]


[[Category:Drugs]]
[[Category:Drugs]]
[[Category:Psychedelic]]
[[Category:Psychedelic]]
[[Category:Research Chemical]]

Latest revision as of 11:52, 3 April 2015

5-MeO-DMT was first discovered in Dictyoloma incanescens and later was isolated from Anadenanthera peregrina as well. It occurs in a very large number of plants, often in association with N,N-DMT. Its effects are somewhat more potent than those of N,N-DMT. When the two are administered simultaneously, 5-MeO-DMT more quickly occupies the specific receptors. 5-MeO-DMT is a natural neurotransmitter in the human nervous system. When 5-MeO-DMT (10 to 20 mg) is smoked or vaporized and inhaled, the effects are almost immediately apparent, are incredibly extreme, and last about ten minutes. Many people report having shamanic experiences with this substance as well as experiencing states of enlightenment and the clear light of nirvana (Metzner 1988). The Colorado River toad (Bufo alvarius) is native to the area around Tucson, Arizona. These toads spend nine months of the year underground, buried in the mud that keeps them protected from the burning desert sun. The toads emerge from their hiding places with the first rains and begin their courtship (Smith 1982,97-100). They remain visible for only three months. Like all toads, Bufo alvarius develops mucous secretions in two glands that are located on the neck The secretions of the Colorado River toad, however, do not contain bufotoxine, the toxic substance that is found in the secretions of most other toads. Instead, the dried mass contains 15% 5-MeO-DMT (Erspamer et al. 1965, 1967). The native tribes that lived in the North American Southwest made fetishes of this Bufo alvarius. However, it was only in recent times that the toad's cultural importance and its psychedelic use were discovered, or more likely rediscovered (cf. Davis and Weil 1992). The toad is "milked" by being held firmly without being crushed. Both glands are then massaged gently until a fat stream of the secretion squirts out. The secretion is caught on a piece of glass, where it is allowed to dry and crystallize. The yellowish crystalline mass then can be scraped off, mixed with different herbs (such as damiana [Turnera diffusa] ), and smoked. The toad, which is released unharmed, is quickly able to replenish the loss in its secretions. When taken orally, Bufo alvarius secretions are apparently toxic, whereas they are not poisonous when smoked (Weil and Davis 1994). Davis and Weil have suggested that the dried secretions of Bufo alvarius were traded to Mexico in preColumbian times and that the priests and shamans there smoked or used it in some other manner (Davis and Weil1992; cf. balche', bufotenine). In Arizona, there is now a Church of the Toad of Light, which uses the secretions of Bufo alvarius as a sacrament (Most 1984; Ott 1993,396*).

Dosage

Smoked/Vaporized
Light 2-5 mg
Common 5-10 mg
Strong 10-20 mg
Insufflated
Light 3-5 mg
Common 5-10 mg
Strong 8-15 mg

Duration

Smoked/Vaporized
Onset 0-1 minutes
Total 5-15 hours
After-effects 15-60 hours (dose-dependent)
Insufflated
Onset 1-5 minutes
Total 15-45 hours
After-effects 1-3 hours (dose-dependent)

Effects

Postive

  • Immersive experiences
  • Profound life-changing spiritual experiences
  • Occasional euphoria
  • Sensual enhancement

Neutral

  • Short Duration
  • Abnormal vocalizations
  • Dissociation
  • Muscle jerking

Negative

  • Fear
  • Panic
  • Overly-intense experiences
  • Hard on the lungs to smoke

Harm Reduction

Interactions

Check out our Drug Combinations page and chart for interactions and combinations of common drugs.

Chemistry and Pharmacology

LD50

115 mg/kg in mice

Links

Erowid

Wikipedia

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