Oxymorphone: Difference between revisions

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= General information =
'''Oxymorphone''' is a powerful semi-synthetic opioid analgesic. It's seven times more potent than morphine itself thus having a 0.4mg:10mg Morphine ratio. (Assuming 100% bioavailability with both substances)
 
Oxymorphone is a powerful semi-synthetic opioid analgesic. It's seven times more potent than morphine itself thus having a 0.4mg:10mg Morphine ratio. (Assuming 100% bioavailability with both substances)
 
Oxymorphone is found in three forms that are used in medical practice and what most of us would encounter if using the drug recreationally.  
Oxymorphone is found in three forms that are used in medical practice and what most of us would encounter if using the drug recreationally.  
Opana IR (Instant release) which is available in 5mg and 10mg tablets.  
Opana IR (Instant release) which is available in 5mg and 10mg tablets.  
Opana ER (Extended Release) Which is available in 5, 10, 20, 30, and 40mg tablets. (Generic Opana ER comes in 7.5mg and 15mg tablets)
Opana ER (Extended Release) Which is available in 5, 10, 20, 30, and 40mg tablets. (Generic Opana ER comes in 7.5mg and 15mg tablets)
Oxymorphone Ampoules which are very rare, but come as 1mg/ml.  
Oxymorphone Ampoules which are very rare, but come as 1mg/ml.  
Because Oxymorphone is from the opioid family, users should experience major caution when using this substance for many days in a row, and also avoid mixing any other depressants when in use with them. (Some examples are Alcohol, Benzodiazepines, Barbiturates and/or other opioids)  
Because Oxymorphone is from the opioid family, users should experience major caution when using this substance for many days in a row, and also avoid mixing any other depressants when in use with them. (Some examples are Alcohol, Benzodiazepines, Barbiturates and/or other opioids)  
Oxymorphone before the half of the old formulation it was commonly taken insufflated. Now with the addition of the new ER mechanism, users are either changing to a different substance, or they are using one of the methods used to break that ER mechanism. Which are very tedious and in my opinion not worth it, but you should be able to find a TEK online rather easily.   
Oxymorphone before the half of the old formulation it was commonly taken insufflated. Now with the addition of the new ER mechanism, users are either changing to a different substance, or they are using one of the methods used to break that ER mechanism. Which are very tedious and in my opinion not worth it, but you should be able to find a TEK online rather easily.   
== History ==
== History ==
Oxymorphone was first developed in Germany in 1914. Then patented in the USA by Enda Pharmaceuticals in 1955. Which was then introduced to the United States in January of 1959, and other countries during the same time. It was designed to have a fewer side effects compared to Morphine and Heroin.  
Oxymorphone was first developed in Germany in 1914. Then patented in the USA by Enda Pharmaceuticals in 1955. Which was then introduced to the United States in January of 1959, and other countries during the same time. It was designed to have a fewer side effects compared to Morphine and Heroin.  


= Dosage =
== Dosage ==
 
Bioavailability of each route of administration. '''Note: Do not take these dosages as a god send. These are rough estimations off users' experience with it. Be safe and remember you can always take more, but you can never take less.'''


== Oral ==
Bioavailability of each route of administration. '''Note: Do not take these dosages as dictionary. These are rough estimations off users' experience with it. Be safe and remember you can always take more, but you can never take less.'''


10% (You can increase this by taking a large meal of fatty foods before taking it, which could raise the BA up to as high as 40%). Crushing the pill as finely as possible could make it hit stronger, but also make it last shorter.  
Note that Opana contains much material which binds to mucous membranes in the nose, for this reason it is difficult to insufflate.  


Light: 5-8mg
Never inject a pill without a micron filter and a clean syringe.


Common: 10-20mg
{| class="wikitable"
|+ Oral
|-
| Light || 5-8mg
|-
| Common || 10-20mg
|-
| Strong || 20mg+
|}


Strong: 20mg+
{| class="wikitable"
|+ Insufflated
|-
| Light || 2-4mg
|-
| Common || 5-10mg
|-
| Strong || 10-15mg+
|}


== Insufflated ==
{| class="wikitable"
|+ Rectal
|-
| Light || 5-8mg
|-
| Common || 10-20mg
|-
| Strong || 20mg+
|}


~43% (Opana contains a lot of powder that binds to the mucus membranes in your nose. It is not an easy drug to insufflate)
{| class="wikitable"
|+ Intravenous
|-
| Light || 1-2mg
|-
| Common || 2-5mg
|-
| Strong || 5-10mg+
|}


Light: 2-4mg
== Duration ==


Common: 5-10mg
{| class="wikitable"
|+ Oral
|-
| Onset (IR) || 20-40 minutes
|-
| Onset(ER) || 60-90 minutes
|-
| Total || 6-12 hours
|}


Strong: 10-15mg+
{| class="wikitable"
|+ Insufflated
|-
| Onset || 1-10 minutes
|-
| Total || 3-4 hours
|}


== Rectal ==
{| class="wikitable"
|+ Rectal
|-
| Onset || 15-30 minutes
|-
| Total || 4-6 hours
|}


Up to 50% (Comparable to oral administration, and would lower nausea and vomiting)
{| class="wikitable"
|+ Intravenous
|-
| Onset || Instant
|-
| Total || 2-3 hours
|}


Light: 5-8mg
== Effects ==


Common: 10-20mg
=== Positive ===
 
Strong: 20mg+
 
== Intravenous ==
 
98%+ '''(NOTE: Never inject a pill without a micron filter and a clean syringe)'''
 
Light: 1-2mg
 
Common: 2-5mg
 
Strong: 5-10mg+
 
= Duration =
 
== Oral ==
 
IR Onset: 20-40 minutes
 
ER Onset: 60-90 minutes
 
Total Duration: 6-12 hours
 
== Insufflated ==
 
Onset: Near instant within 10 minutes
 
Total Duration: 3-4 hours
 
== Rectal ==
 
Onset: 15-30 minutes
 
Total Duration: 4-6 hours
 
== Intravenous ==
 
Onset: Instant
 
Total Duration: 2-3 hours
 
= Effects =
 
== Positive ==


* A sense of well being.  
* A sense of well being.  
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* Analgesia
* Analgesia


== Neutral ==
=== Neutral ===


* Pupil Constriction
* Pupil Constriction
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* Sedation
* Sedation


== Negative ==
=== Negative ===


* CNS Depression
* CNS Depression
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* Sweating
* Sweating


= Harm Reduction ==
== Harm Reduction ==


There has been some reports of a rare blood disease linked with intravenous injection since the new formulation (early 2012) came out. Read more about it [http://www.medpagetoday.com/Nephrology/GeneralNephrology/36819 here]
There has been some reports of a rare blood disease linked with intravenous injection since the new formulation (early 2012) came out. Read more about it [http://www.medpagetoday.com/Nephrology/GeneralNephrology/36819 here]
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Like with all other opioids/opiates there is a chance of addiction and tolerance occurring with the use. Please keep that in mind if you plan on using this substance or any others in this class.
Like with all other opioids/opiates there is a chance of addiction and tolerance occurring with the use. Please keep that in mind if you plan on using this substance or any others in this class.


== Potentiators ==
=== Potentiators ===


* All First generation Anti-Histamines
* All First generation Anti-Histamines
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* Benzodiazapines
* Benzodiazapines


== Avoid ==
=== Avoid ===


* All other CNS depressants (such as alcohol and benzodiazapines) as it could be too much sedation and you can overdose more easily.
* All other CNS depressants (such as alcohol and benzodiazapines) as it could be too much sedation and you can overdose more easily.


= Legal status =
== Chemistry and Pharmacology ==
=== Bioavailability ===
 
{| class="wikitable"
|+ Bioavailabilities
|-
| Oral || 10% (can be improved up to 40% by eating a large meal of fatty foods)
|-
| Insufflated || 43%
|-
| Rectal || Up to 50%
|-
| Intravenous || 98%+
|}
 
 
== Legal status ==


* United States: Schedule II: Illegal to buy, sell, and possess without a prescription.
* United States: Schedule II: Illegal to buy, sell, and possess without a prescription.

Latest revision as of 00:56, 11 March 2015

Oxymorphone is a powerful semi-synthetic opioid analgesic. It's seven times more potent than morphine itself thus having a 0.4mg:10mg Morphine ratio. (Assuming 100% bioavailability with both substances) Oxymorphone is found in three forms that are used in medical practice and what most of us would encounter if using the drug recreationally. Opana IR (Instant release) which is available in 5mg and 10mg tablets. Opana ER (Extended Release) Which is available in 5, 10, 20, 30, and 40mg tablets. (Generic Opana ER comes in 7.5mg and 15mg tablets) Oxymorphone Ampoules which are very rare, but come as 1mg/ml. Because Oxymorphone is from the opioid family, users should experience major caution when using this substance for many days in a row, and also avoid mixing any other depressants when in use with them. (Some examples are Alcohol, Benzodiazepines, Barbiturates and/or other opioids) Oxymorphone before the half of the old formulation it was commonly taken insufflated. Now with the addition of the new ER mechanism, users are either changing to a different substance, or they are using one of the methods used to break that ER mechanism. Which are very tedious and in my opinion not worth it, but you should be able to find a TEK online rather easily.

History

Oxymorphone was first developed in Germany in 1914. Then patented in the USA by Enda Pharmaceuticals in 1955. Which was then introduced to the United States in January of 1959, and other countries during the same time. It was designed to have a fewer side effects compared to Morphine and Heroin.

Dosage

Bioavailability of each route of administration. Note: Do not take these dosages as dictionary. These are rough estimations off users' experience with it. Be safe and remember you can always take more, but you can never take less.

Note that Opana contains much material which binds to mucous membranes in the nose, for this reason it is difficult to insufflate.

Never inject a pill without a micron filter and a clean syringe.

Oral
Light 5-8mg
Common 10-20mg
Strong 20mg+
Insufflated
Light 2-4mg
Common 5-10mg
Strong 10-15mg+
Rectal
Light 5-8mg
Common 10-20mg
Strong 20mg+
Intravenous
Light 1-2mg
Common 2-5mg
Strong 5-10mg+

Duration

Oral
Onset (IR) 20-40 minutes
Onset(ER) 60-90 minutes
Total 6-12 hours
Insufflated
Onset 1-10 minutes
Total 3-4 hours
Rectal
Onset 15-30 minutes
Total 4-6 hours
Intravenous
Onset Instant
Total 2-3 hours

Effects

Positive

  • A sense of well being.
  • Euphoria
  • Analgesia

Neutral

  • Pupil Constriction
  • Itching
  • Sedation

Negative

  • CNS Depression
  • Drowsiness
  • Dizziness
  • Nausea
  • Vomiting
  • Constipation
  • Sweating

Harm Reduction

There has been some reports of a rare blood disease linked with intravenous injection since the new formulation (early 2012) came out. Read more about it here

Like with all other opioids/opiates there is a chance of addiction and tolerance occurring with the use. Please keep that in mind if you plan on using this substance or any others in this class.

Potentiators

  • All First generation Anti-Histamines
  • Grapefruit Juice
  • Alchohol
  • Benzodiazapines

Avoid

  • All other CNS depressants (such as alcohol and benzodiazapines) as it could be too much sedation and you can overdose more easily.

Chemistry and Pharmacology

Bioavailability

Bioavailabilities
Oral 10% (can be improved up to 40% by eating a large meal of fatty foods)
Insufflated 43%
Rectal Up to 50%
Intravenous 98%+


Legal status

  • United States: Schedule II: Illegal to buy, sell, and possess without a prescription.
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