Volumetric dosing is a relatively easy way to accurately dose substances in the sub-milligram range. It involves dissolving a known quantity of a substance in a known quantity of water, from there it's very easy to find the concentration of the substance on a milliliter basis.
Some substances, such as the NBOMeN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. series, are active at sub-milligram doses. These types of chemicals require extreme precision that can't be achieved with consumer grade scales. Volumetric dosing is the only way to dose something like that in a safe and reliable manner.
- Research what your substance can be dissolved in, and at what concentrations. Some drugs (Such as alprazolam powder) are not dissolved readily in water, and instead need a strong spirit such as PGP or everclear. Sometimes, it is necessary to use a stronger solute when a higher concentration is desired.
- Take the substance you wish to dissolve, and weigh it with an accurate milligram scale. (Generally you measure out a substantial amount more than you intend on dosing, to increase the margin of error)
- Once you have a known quantity, you need to decide what concentration you want it. For example, if I have 100mg of 25i-NBOMeN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. in powder, and I want 500µg in every milliliter of solute (A concentration of 500µg/mL) I would need 200mL of solute.
- The concentration can be calculated with the following formula
- quantity of substance / amount of solute = concentration.
- Ex. 100mg/200mL=500µg per mL
- Remember: The lower the concentration, the easier and safer it is to dose! Ensure your margin for error is as high as necessary.