(Replaced content with "Category:Drugs Category:Psychedelic")
Line 1: Line 1:
 
<table style="font-family: Arial, Helvetica, sans-serif; font-size: 9pt;" width="100%" border="0" cellspacing="0" cellpadding="0">
 
 
<tr>
 
<td valign="top" width="50%"><strong>Other Names</strong>
 
 
Agarin, 5-(aminomethyl)-3- [2H] -isoxazolone, pyroibotenic
 
 
acid, 3-hydroxy-5-aminomethyl-isoxazole
 
 
Substance type: amino acid, isoxazole derivative
 
 
Muscimol was first described in 1964 as a constituent
 
 
of Amanita pantherina. Muscimol is the
 
 
decarboxylated product of ibotenic acid and is
 
 
considered to be more psychoactive than it. Some
 
 
15 to 20 mg is regarded as a psychoactive dosage
 
 
(Muller and Eugster 1965; Ott 1993,446*; Scotti et
 
 
al. 1969).
 
 
Muscimol is an analog of the neurotransmitter
 
 
GABA (gamma amino butyric acid) and docks to
 
 
its receptor (Johnston 1971). Kavapyrones (cf.
 
 
Piper methysticum) also bind to the same receptor.
 
 
Ibotenic acid as well as muscimol were detected
 
 
in the urine of people who had eaten fly agaric
 
 
mushrooms (Amanita muscaria) about an hour
 
 
earlier. An experiment with mice conducted by the
 
 
same team of researchers found that the amount of
 
 
active constituents in the urine passed by one
 
 
inebriated animal was not sufficient to inebriate
 
 
another animal (Ott et al. 1975).</td>
 
<td valign="top" width="53%"><strong>Commercial Forms and Regulations
 
 
</strong>Muscimol can be purchased from chemical suppliers.
 
 
The substance is legal and is not subject to
 
 
any specific regulations.
 
 
<strong>
 
 
Literature</strong>
 
 
See also the entries for Amanita muscaria and
 
 
ibotenic acid.
 
 
Johnston, G. A. R. 1971. Muscimol and the uptake of
 
 
,),-aminobutyric acid by rat brain slices.
 
 
Psychopharmacologia 22:230.
 
 
Muller, G. F. R., and C. H. Eugster. 1965. Muscimol,
 
 
ein pharmakodynamisch wirksamer Stoff aus
 
 
Amanita muscaria. Helvetica Chemica Acta
 
 
48:910-26.
 
 
Ott, Jonathan, Preston S. Wheaton, and William
 
 
Scott Chilton. 1975. Fate of muscimol in the
 
 
mouse. Physiol. Chem. and Physics 7:381-84.
 
 
Scotti de Carolis, A., et al. 1969.
 
 
Neuropharmacological investigations on
 
 
muscimol, a psychotropic drug extracted from
 
 
Amanita muscaria. Psychopharmacologia
 
 
15:186-95.</td>
 
</tr>
 
 
</table>
 
 
 
 
[[Category:Drugs]]
 
[[Category:Drugs]]
 
[[Category:Psychedelic]]
 
[[Category:Psychedelic]]

Revision as of 15:44, 14 July 2014

Top Contributors