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Revision as of 18:37, 13 January 2013

Other Names

Agarin, 5-(aminomethyl)-3- [2H] -isoxazolone, pyroibotenic

acid, 3-hydroxy-5-aminomethyl-isoxazole

Substance type: amino acid, isoxazole derivative

Muscimol was first described in 1964 as a constituent

of Amanita pantherina. Muscimol is the

decarboxylated product of ibotenic acid and is

considered to be more psychoactive than it. Some

15 to 20 mg is regarded as a psychoactive dosage

(Muller and Eugster 1965; Ott 1993,446*; Scotti et

al. 1969).

Muscimol is an analog of the neurotransmitter

GABAGamma aminobutyric acid an amino acid that is found in the central nervous system; acts as an inhibitory neurotransmitter. (gamma amino butyric acid) and docks to

its receptor (Johnston 1971). Kavapyrones (cf.

Piper methysticum) also bind to the same receptor.

Ibotenic acid as well as muscimol were detected

in the urine of people who had eaten fly agaric

mushrooms (Amanita muscaria) about an hour

earlier. An experiment with mice conducted by the

same team of researchers found that the amount of

active constituents in the urine passed by one

inebriated animal was not sufficient to inebriate

another animal (Ott et al. 1975).
Commercial Forms and Regulations

Muscimol can be purchased from chemical suppliers.

The substance is legal and is not subject to

any specific regulations.

Literature

See also the entries for Amanita muscaria and

ibotenic acid.

Johnston, G. A. R. 1971. Muscimol and the uptake of

,),-aminobutyric acid by rat brain slices.

Psychopharmacologia 22:230.

Muller, G. F. R., and C. H. Eugster. 1965. Muscimol,

ein pharmakodynamisch wirksamer Stoff aus

Amanita muscaria. Helvetica Chemica Acta

48:910-26.

Ott, Jonathan, Preston S. Wheaton, and William

Scott Chilton. 1975. Fate of muscimol in the

mouse. Physiol. Chem. and Physics 7:381-84.

Scotti de Carolis, A., et al. 1969.

Neuropharmacological investigations on

muscimol, a psychotropic drug extracted from

Amanita muscaria. Psychopharmacologia

15:186-95.

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