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'''Morphine''' is an opiate used in the treatment of severe pain. It occurs naturally in the opium poppy and has a long history of human use.
  
<table style="font-family: Arial, Helvetica, sans-serif; font-size: 9pt;" width="100%" border="0" cellspacing="0" cellpadding="0">
+
Morphine does not bind well to the encephalin receptors (to which the endorphins dock) but docks at the specific morphine (m) receptors (Hazum et al. 1981). It is most likely biosynthesized in the body from dopamine (Brossi 1991). Another closely related substance, codeine, is also endogenous in humans (Cardinale et al. 1987). Morphine is the best and strongest natural painkiller known. Its efficaciousness is surpassed only by that of the synthetic morphine analogues (heroin, fentanyl). Morphine is particularly well suited for treating chronic pain, such as in cancer therapy (Amann and Zenk 1996; Melzack 1991). Endogenous morphine constitutes the body's own pain medication: Studies on rats have shown that among animals who were suffering from arthritis, morphine concentrations in the spinal cord and urine were significantly elevated. Because of this, it is assumed today that the organism produces increased amounts of morphine in certain disease states. Consequently, endogenous morphine may serve to regulate pain in the organism. Morphine exists in animal and human tissue and is excreted in significant amounts in the urine. (Amann and Zenk 1996,24)
  
<tr>
+
About 30 mg orally represents an effective dosage. Habitual morphine users may use as much as 1 g per day (Hirschfeld and Linsert 1930,255*): It is known that opium eaters experience a significant increase in sexual functions during the initial period of opium consumption. During opium inebriation, erotic images appear and may even include extraordinary sexual fantasies. The effects of morphine are similar, where an increase in sexual excitability was observed following several weeks of taking 0.03 to 0.06 g per day. (Max Marcuse, 1923, Handworterbuch der Sexualwissenschaft [Handbook of Sexual Sciences] ) When used for sedation, in anesthesia, and for calming and antispasmodic purposes, pharmaceutical preparations of morphine hydrochloride and atropine sulfate or morphine hydrochloride and scopolamine hydrobromide are used-the final reminders of the recipes for the former soporific sponges.
<td valign="top" width="50%"><strong>Other Names</strong>
+
  
4,5a-epoxy-17-methyl-7-morphinen-3,6a-diol,
+
== History ==
  
morfina, morphin, morphinium, morphium
+
Sometime around 1803 and 1804, Friedrich Wilhelm Adam Serturner (1783-1841), a pharmacist's assistant, first isolated morphine as the "sleep-inducing principle" in opium (cf. Papaver somniferum, opium alkaloids). This achievement was the most important "quantum leap" in the history of pharmacology and represents the beginning of the true chemical investigation of plants. Today, the Serturner Medal is still awarded for exceptional work in pharmaceutics. Morphine may also be present in Papaver decaisnei Hochst., Papaver dubium 1. [syn. Papaver modestum Jordan, Papaver obtusifolium Desf.], and Papaver hybridum 1. (Slavik and Slavikova 1980). Whether morphine occurs in Argemone mexicana and other Papaver species (Papaver spp.) is doubtful, while the idea that hops (Humulus lupulus) contains morphine is a figment of someone's imagination. Tiny traces of the substance have been found in hay and lettuce (cf. Lactuca virosa) (Amann and Zenk 1996, 19). Morphine has also been detected in the skin of Bufo marinus toads (cf. bufotenine) (Amann and Zenk 1996, 18). Since the time when morphine was first detected in breast milk, cow's milk, and human cerebrospinal fluid, it has been known that it is a natural endogenous neurotransmitter in higher vertebrates, including humans (Amann and Zenk 1996; Cardinale et al. 1987; Hazum et al. 1981).
  
Substance type: opium alkaloid
+
During the Golden Twenties, the use of morphine in Berlin society circles was depicted in numerous pictures and illustrations (e.g., by Paul Kamm) that appeared in magazines. These illustrations played a great role in creating the stereotype of the "Morphinist" (cf. Papaver somniferum), who also became the object of literary treatments (Bulgaka 1971; Mac From 1931). Even the life story of the man who first discovered the substance, Friedrich Wilhelm Sertiirner, became the subject of a novel (Schumann-Ingolstadt n.d.). Heroin, a derivative of morphine, has also inspired a rich body of literature. One of the first of this was the novel Heroin, by Rudolf Brunngraber (1952*), which dealt with the role of heroin in Egypt during the Golden Twenties. Morphine was and still is a popular inebriant in the music scene (particularly that of jazz and rock). "Sister Morphine," a song by the Rolling Stones (Sticky Fingers, Virgin Records, 1971), is arguably the most famous hymn to the drug. Morphine, a crossover band that mixes elements of cool jazz and modern rock, took its name from the alkaloid, and one of its albums is titled Cure for Pain (Rykodisc, 1993).
  
Sometime around 1803 and 1804, Friedrich
+
== Dosage ==
  
Wilhelm Adam Serturner (1783-1841), a
+
{| class="wikitable"
 +
|+ Oral
 +
|-
 +
| Light || 10mg
 +
|-
 +
| Common || 15-20mg
 +
|-
 +
| Strong || 30mg+
 +
|}
  
pharmacist's assistant, first isolated morphine as
+
== Duration ==
  
the "sleep-inducing principle" in opium (cf.
+
{| class="wikitable"
 +
|+ Oral
 +
|-
 +
| Onset (IR) || 10-30 minutes
 +
|-
 +
| Onset (ER) || 40-80 minutes
 +
|-
 +
| Total || 4-6 hours
 +
|}
  
Papaver somniferum, opium alkaloids). This
+
{| class="wikitable"
 +
|+ Insufflated
 +
|-
 +
| Onset || 10-30 minutes
 +
|-
 +
| Total || 4-5 hours
 +
|}
  
achievement was the most important "quantum
+
{| class="wikitable"
 +
|+ Rectal
 +
|-
 +
| Onset || 10-30 minutes
 +
|-
 +
| Total || 3-4 hours
 +
|}
  
leap" in the history of pharmacology and represents the beginning of the true chemical investigation
+
{| class="wikitable"
 +
|+ Intravenous & Intramuscular
 +
|-
 +
| Onset || Nearly immediate
 +
|-
 +
| Total || 2-4 hours
 +
|}
  
of plants. Today, the Serturner Medal is still
+
== Effects ==
  
awarded for exceptional work in pharmaceutics.
+
=== Positive ===
  
Morphine may also be present in Papaver
+
* Euphoria
  
decaisnei Hochst., Papaver dubium 1. [syn. Papaver
+
* Pain relief
  
modestum Jordan, Papaver obtusifolium Desf.],
+
* Elevated mood
  
and Papaver hybridum 1. (Slavik and Slavikova
+
* Overall feeling of contentedness
  
1980). Whether morphine occurs in Argemone
+
=== Neutral ===
  
mexicana and other Papaver species (Papaver
+
* Itching
  
spp.) is doubtful, while the idea that hops (Humulus
+
=== Negative ===
  
lupulus) contains morphine is a figment of
+
* Nausea
  
someone's imagination. Tiny traces of the
+
* Constipation
  
substance have been found in hay and lettuce (cf.
+
* CNS depression
  
Lactuca virosa) (Amann and Zenk 1996, 19).
+
* Drowsiness
  
Morphine has also been detected in the skin of Bufo marinus toads (cf. bufotenine) (Amann and
+
* Hot/cold flashes
  
Zenk 1996, 18).
+
* Dizziness
  
Since the time when morphine was first
+
* Vomiting
  
detected in breast milk, cow's milk, and human
+
* Urinary retention (difficulty urinating)
  
cerebrospinal fluid, it has been known that it is a
+
* Potential psychosis from heavy use
  
natural endogenous neurotransmitter in higher
+
== Harm Reduction ==
  
vertebrates, including humans (Amann and Zenk
+
* Do not mix with alcohol, benzodiazapines, or other CNS depressants
  
1996; Cardinale et al. 1987; Hazum et al. 1981).
+
* Do not drive or operate heavy machinery
  
Morphine does not bind well to the encephalin
+
[[Category:Drugs]]
  
receptors (to which the endorphins dock) but
+
[[Category:Opioid]]
  
docks at the specific morphine (m) receptors
+
[[Category:Depressant]]
  
(Hazum et al. 1981). It is most likely biosynthesized
+
[[Category:Chemicals]]
 
+
in the body from dopamine (Brossi 1991).
+
 
+
Another closely related substance, codeine, is also
+
 
+
endogenous in humans (Cardinale et al. 1987).
+
 
+
Morphine is the best and strongest natural
+
 
+
painkiller known. Its efficaciousness is surpassed
+
 
+
only by that of the synthetic morphine analogs
+
 
+
(heroin, fentanyl). Morphine is particularly well
+
 
+
suited for treating chronic pain, such as in cancer
+
 
+
therapy (Amann and Zenk 1996; Melzack 1991).
+
 
+
Endogenous morphine constitutes the body's own
+
 
+
pain medication:
+
 
+
Studies on rats have shown that among
+
 
+
animals who were suffering from arthritis,
+
 
+
morphine concentrations in the spinal cord
+
 
+
and urine were significantly elevated. Because
+
 
+
of this, it is assumed today that the organism
+
 
+
produces increased amounts of morphine in
+
 
+
certain disease states. Consequently, endogenous
+
 
+
morphine may serve to regulate pain
+
 
+
in the organism. Morphine exists in animal
+
 
+
and human tissue and is excreted in significant
+
 
+
amounts in the urine. (Amann and Zenk
+
 
+
1996,24)
+
 
+
About 30 mg orally represents an effective
+
 
+
dosage. Habitual morphine users may use as much
+
 
+
as 1 g per day (Hirschfeld and Linsert 1930,255*):
+
 
+
It is known that opium eaters experience a
+
 
+
significant increase in sexual functions during
+
 
+
the initial period of opium consumption.
+
 
+
During opium inebriation, erotic images
+
 
+
appear and may even include extraordinary
+
 
+
sexual fantasies.... The effects of morphine
+
 
+
are similar, where an increase in sexual
+
 
+
excitability was observed following several
+
 
+
weeks of taking 0.03 to 0.06 g per day. (Max
+
 
+
Marcuse, 1923, Handworterbuch der Sexualwissenschaft
+
 
+
[Handbook of Sexual Sciences] )
+
 
+
When used for sedation, in anesthesia, and for
+
 
+
calming and antispasmodic purposes, pharmaceutical
+
 
+
preparations of morphine hydrochloride and
+
 
+
atropine sulfate or morphine hydrochloride and scopolamine
+
 
+
hydrobromide are used-the final
+
 
+
reminders of the recipes for the former soporific
+
 
+
sponges.
+
 
+
During the Golden Twenties, the use of morphine
+
 
+
in Berlin society circles was depicted in
+
 
+
numerous pictures and illustrations (e.g., by Paul
+
 
+
Kamm) that appeared in magazines. These illustrations
+
 
+
played a great role in creating the stereotype
+
 
+
of the "Morphinist" (cf. Papaver somniferum),
+
 
+
who also became the object of literary treatments
+
 
+
(Bulgaka 1971; Mac From 1931). Even the life
+
 
+
story of the man who first discovered the substance,
+
 
+
Friedrich Wilhelm Sertiirner, became the
+
 
+
subject of a novel (Schumann-Ingolstadt n.d.).
+
 
+
Heroin, a derivative of morphine, has also inspired
+
 
+
a rich body of literature. One of the first of this
+
 
+
was the novel Heroin, by Rudolf Brunngraber
+
 
+
(1952*), which dealt with the role of heroin in
+
 
+
Egypt during the Golden Twenties.
+
 
+
Morphine was and still is a popular inebriant
+
 
+
in the music scene (particularly that of jazz and
+
 
+
rock). "Sister Morphine," a song by the Rolling
+
 
+
Stones (Sticky Fingers, Virgin Records, 1971), is
+
 
+
arguably the most famous hymn to the drug.
+
 
+
Morphine, a crossover band that mixes elements
+
 
+
of cool jazz and modern rock, took its name from
+
 
+
the alkaloid, and one of its albums is titled Cure for
+
 
+
Pain (Rykodisc, 1993).</td>
+
<td valign="top" width="53%"><strong>Cacti Containing Mescaline</strong>
+
 
+
(from Doetsch et al. 1980; La Barre 1979; Mata and McLaughlin 1982*; Shulgin 1995*; Lundstrom
+
 
+
1971; Pardanini et al. 1978; Ott 1993*; Turner and Heyman 1960)
+
<table style="font-family: Arial, Helvetica, sans-serif; font-size: 9pt;" cellspacing="0" cellpadding="0">
+
 
+
<tr>
+
<td valign="top" width="213"><strong>Species</strong></td>
+
<td valign="top" width="213"><strong>Occurrence</strong></td>
+
<td valign="top" width="213"><strong>Use</strong></td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Gymnocalycium gibbosum </em>(Haw.) Pfeiffer</td>
+
<td valign="top" width="213">Argentina</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Gymnocalycium leeanum </em>(Hook.) Br. et R.</td>
+
<td valign="top" width="213">Argentina, Uruguay</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Islaya minor </em>Backeb.</td>
+
<td valign="top" width="213">southern Peru</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Lophophora diffusa </em>(Croizat) Bravo</td>
+
<td valign="top" width="213">Mexico</td>
+
<td valign="top" width="213">peyote substitute</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213">[syn. <em>Lophophora echinata]</em></td>
+
<td valign="top" width="213">&nbsp;</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Lophophora jourdaniana </em>[nom. nud.]</td>
+
<td valign="top" width="213">&nbsp;</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Lophophora williamsii </em>(Lem.) Coult.</td>
+
<td valign="top" width="213">Mexico</td>
+
<td valign="top" width="213">entheogen</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213">[syn. <em>Lophophora fricii </em>Habermann]</td>
+
<td valign="top" width="213">&nbsp;</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Myrtillocactus geometrizans </em>(Mart.) Cons.</td>
+
<td valign="top" width="213">Mexico</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Opuntia acanthocarpa </em>Engelm. et Bigel.</td>
+
<td valign="top" width="213">&nbsp;</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Opuntia basilaria </em>Engelm. et Bigel.</td>
+
<td valign="top" width="213">&nbsp;</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Opuntia cylindrica </em>(Lam.) S.-D.</td>
+
<td valign="top" width="213">Chile</td>
+
<td valign="top" width="213">inebriant502</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Opuntia echinocarpa </em>Engelm. et Bigel.</td>
+
<td valign="top" width="213">&nbsp;</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Opuntia ficus-indica </em>(L.) Mill.</td>
+
<td valign="top" width="213">Mexico, Egypt503</td>
+
<td valign="top" width="213">food</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Opuntia imbricata </em>(Haw.) DC.</td>
+
<td valign="top" width="213">Arizona</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Opuntia spinosior </em>(Engelm.) Tourney</td>
+
<td valign="top" width="213">Arizona</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Pelecyphora aselliformis </em>Ehrenb.</td>
+
<td valign="top" width="213">Mexico</td>
+
<td valign="top" width="213">peyote substitute</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Pereskia corrugata </em>Cutak</td>
+
<td valign="top" width="213">Florida</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Pereskia tampicana </em>Web.</td>
+
<td valign="top" width="213">Mexico</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Pereskiopsis scandens </em>Br. et R.</td>
+
<td valign="top" width="213">Yucatan</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Polaskia chende </em>(Gossel.) Gibs.</td>
+
<td valign="top" width="213">California</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Polaskia </em>sp.</td>
+
<td valign="top" width="213">California</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Pterocereus gaumeri </em>(Br. et R.) Mac-Doug. et Mir.</td>
+
<td valign="top" width="213">California</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Pterocereus </em>sp.</td>
+
<td valign="top" width="213">California</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Stenocereus beneckei </em>(Ehrenb.) Buxbaum</td>
+
<td valign="top" width="213">California</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Stenocereus eruca </em>(Brand.) Gibs. et Horak</td>
+
<td valign="top" width="213">Baja California</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Stenocereus stellatus </em>(Pfeiffer) Rice</td>
+
<td valign="top" width="213">California</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Stenocereus treleasei </em>(Br. et R.) Backeb.</td>
+
<td valign="top" width="213">California</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Stenocereus </em>sp.</td>
+
<td valign="top" width="213">&nbsp;</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Stetsonia coryne </em>(SD.) Br. et R.</td>
+
<td valign="top" width="213">Argentina</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus bridgesii </em>(SD.) Br. et R.</td>
+
<td valign="top" width="213">Peru, Bolivia</td>
+
<td valign="top" width="213">entheogen</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus cuscoensis </em>Br. et R.</td>
+
<td valign="top" width="213">Peru</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus fulvinanus </em>Ritt.</td>
+
<td valign="top" width="213">Chile</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus macrogonus </em>(SD.) Ricc.</td>
+
<td valign="top" width="213">Peru</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus pachanoi </em>Br. et R.</td>
+
<td valign="top" width="213">Peru, Ecuador</td>
+
<td valign="top" width="213">entheogen</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus peruvianus </em>Br. et R.</td>
+
<td valign="top" width="213">Peru</td>
+
<td valign="top" width="213">entheogen</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus spachianus </em>(Lem.) Rice.</td>
+
<td valign="top" width="213">Indiana (cultivated)</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus strigosus </em>(SD.) Br. et R.</td>
+
<td valign="top" width="213">Argentina</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus taquimbalensis </em>Card.</td>
+
<td valign="top" width="213">Peru</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus terscheckii </em>(Parm.) Br. et R.</td>
+
<td valign="top" width="213">Peru, northwestern</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus validus </em>(Monv.) Backbg.</td>
+
<td valign="top" width="213">Argentina</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
<tr>
+
<td valign="top" width="213"><em>Trichocereus werdermannianus </em>Backbg.</td>
+
<td valign="top" width="213">Peru, Bolivia</td>
+
<td valign="top" width="213">&nbsp;</td>
+
</tr>
+
 
+
</table>
+
<strong>Commercial Forms and Regulations
+
 
+
</strong>Morphine is available from pharmacies in the
+
 
+
form of morphine hydrochloride. Although morphine
+
 
+
is covered by narcotics laws, it can be
+
 
+
obtained with a special prescription. In the United
+
 
+
States, morphine is a Schedule II substance.
+
 
+
<strong>
+
 
+
Literature</strong>
+
 
+
See also the entries for Papaver somniferum and
+
 
+
Papaver spp.
+
 
+
Amann, Tobias, and Meinhart H. Zenk. 1996.
+
 
+
Endogenes Morphin: Schmerzmittelsynthese in
+
 
+
Mensch und Tier. Deutsche Apotheker Zeitung 136
+
 
+
(7): 17-25. (Contains a very good bibliography.)
+
 
+
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</tr>
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</table>
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Latest revision as of 08:20, 26 May 2015

Morphine is an opiate used in the treatment of severe pain. It occurs naturally in the opium poppy and has a long history of human use.

Morphine does not bind well to the encephalin receptors (to which the endorphins dock) but docks at the specific morphine (m) receptors (Hazum et al. 1981). It is most likely biosynthesized in the body from dopamineA neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system. (Brossi 1991). Another closely related substance, codeine, is also endogenous in humans (Cardinale et al. 1987). Morphine is the best and strongest natural painkiller known. Its efficaciousness is surpassed only by that of the synthetic morphine analogues (heroin, fentanyl). Morphine is particularly well suited for treating chronic pain, such as in cancer therapy (Amann and Zenk 1996; Melzack 1991). Endogenous morphine constitutes the body's own pain medication: Studies on rats have shown that among animals who were suffering from arthritis, morphine concentrations in the spinal cord and urine were significantly elevated. Because of this, it is assumed today that the organism produces increased amounts of morphine in certain disease states. Consequently, endogenous morphine may serve to regulate pain in the organism. Morphine exists in animal and human tissue and is excreted in significant amounts in the urine. (Amann and Zenk 1996,24)

About 30 mg orallyRoute of administration in which the subject swallows a substance. represents an effective dosage. Habitual morphine users may use as much as 1 g per day (Hirschfeld and Linsert 1930,255*): It is known that opium eaters experience a significant increase in sexual functions during the initial period of opium consumption. During opium inebriation, erotic images appear and may even include extraordinary sexual fantasies. The effects of morphine are similar, where an increase in sexual excitability was observed following several weeks of taking 0.03 to 0.06 g per day. (Max Marcuse, 1923, Handworterbuch der Sexualwissenschaft [Handbook of Sexual Sciences] ) When used for sedation, in anesthesia, and for calming and antispasmodic purposes, pharmaceutical preparations of morphine hydrochloride and atropine sulfate or morphine hydrochloride and scopolamine hydrobromide are used-the final reminders of the recipes for the former soporific sponges.

History

Sometime around 1803 and 1804, Friedrich Wilhelm Adam Serturner (1783-1841), a pharmacist's assistant, first isolated morphine as the "sleep-inducing principle" in opium (cf. Papaver somniferum, opium alkaloids). This achievement was the most important "quantum leap" in the history of pharmacology and represents the beginning of the true chemical investigation of plants. Today, the Serturner Medal is still awarded for exceptional work in pharmaceutics. Morphine may also be present in Papaver decaisnei Hochst., Papaver dubium 1. [syn. Papaver modestum Jordan, Papaver obtusifolium Desf.], and Papaver hybridum 1. (Slavik and Slavikova 1980). Whether morphine occurs in Argemone mexicana and other Papaver species (Papaver spp.) is doubtful, while the idea that hops (Humulus lupulus) contains morphine is a figment of someone's imagination. Tiny traces of the substance have been found in hay and lettuce (cf. Lactuca virosa) (Amann and Zenk 1996, 19). Morphine has also been detected in the skin of Bufo marinus toads (cf. bufotenine) (Amann and Zenk 1996, 18). Since the time when morphine was first detected in breast milk, cow's milk, and human cerebrospinal fluid, it has been known that it is a natural endogenous neurotransmitter in higher vertebrates, including humans (Amann and Zenk 1996; Cardinale et al. 1987; Hazum et al. 1981).

During the Golden Twenties, the use of morphine in Berlin society circles was depicted in numerous pictures and illustrations (e.g., by Paul Kamm) that appeared in magazines. These illustrations played a great role in creating the stereotype of the "Morphinist" (cf. Papaver somniferum), who also became the object of literary treatments (Bulgaka 1971; Mac From 1931). Even the life story of the man who first discovered the substance, Friedrich Wilhelm Sertiirner, became the subject of a novel (Schumann-Ingolstadt n.d.). Heroin, a derivative of morphine, has also inspired a rich body of literature. One of the first of this was the novel Heroin, by Rudolf Brunngraber (1952*), which dealt with the role of heroin in Egypt during the Golden Twenties. Morphine was and still is a popular inebriant in the music scene (particularly that of jazz and rock). "Sister Morphine," a song by the Rolling Stones (Sticky Fingers, Virgin Records, 1971), is arguably the most famous hymn to the drug. Morphine, a crossover band that mixes elements of cool jazz and modern rock, took its name from the alkaloid, and one of its albums is titled Cure for Pain (Rykodisc, 1993).

Dosage

Oral
Light 10mg
Common 15-20mg
Strong 30mg+

Duration

Oral
Onset (IR) 10-30 minutes
Onset (ER) 40-80 minutes
Total 4-6 hours
Insufflated
Onset 10-30 minutes
Total 4-5 hours
Rectal
Onset 10-30 minutes
Total 3-4 hours
Intravenous & Intramuscular
Onset Nearly immediate
Total 2-4 hours

Effects

Positive

  • Euphoria
  • Pain relief
  • Elevated mood
  • Overall feeling of contentedness

Neutral

  • Itching

Negative

  • Nausea
  • Constipation
  • CNSCentral Nervous System depression
  • Drowsiness
  • Hot/cold flashes
  • Dizziness
  • Vomiting
  • Urinary retention (difficulty urinating)
  • Potential psychosis from heavy use

Harm Reduction

  • Do not mix with alcohol, benzodiazapines, or other CNSCentral Nervous System depressants
  • Do not drive or operate heavy machinery

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