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== Harm Reduction ==
== Harm Reduction ==
MXE can linger for quite some time in the body, It is poorly metabolized. A detox is necessary to remove it completely. A recommendable detox consists of food grade diatomaceous earth, borax (or boron) and kelp (iodine source)
A recent [https://www.ncbi.nlm.nih.gov/pubmed/30377924 study] on rats indicates that MXE may have harmful effects on the cardiovascular system, and therefor should probably be avoided by anyone with any history of cardiovascular issues.
See [[Dissociatives#Harm_Reduction|Dissociative Harm Reduction]] for general information.
See [[Dissociatives#Harm_Reduction|Dissociative Harm Reduction]] for general information.

Latest revision as of 15:12, 7 November 2018


Methoxetamine (MXEMethoxetamine, 3-MeO-2-Oxo-PCE) is a near chemical analogue of Ketamine and PCP. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDAN-methyl-D-aspartate receptor. NMDA antagonists are often dissociatives. receptor antagonistA substance that interferes with or inhibits the physiological action of another. and unlike ketamine also acts as SerotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. Reuptake Inhibitor (SRISerotonin Reuptake Inhibitor). The N-Ethyl group on this compound increases potency.


Threshold 5-10mg
Light 10-20mg
Common 20-35mg
Strong 35-60mg
Heavy 60mg+
M-Hole 70mg+
Threshold 10-15mg
Light 15-25mg
Common 25-35
Strong 40-65mg
M-Hole 75mg+
Threshold 5-10mg
Low 10-20mg
Common 40-60mg
Strong 60-75mg
M-Hole 75-100mg

Dosages from TripSit Factsheets


Onset 30-60 minutes
Total 3-6 hours
After-effects 2-48 hours (dose-dependent)
Onset 5-40 minutes
Total 3-6 hours
After-effects 2-48 hours (dose-dependent)
Onset 15-45 minutes
Total 3-6 hours
After-effects 2-48 hours (dose-dependent)



  • Euphoria, mood lift
  • Sense of calm and serenity
  • Vivid recall of past memories and dreams
  • Closed- and open-eye visuals (common)
  • Out-of-body experience (less intense then ketamine)


  • Distortion or loss of sensory perceptions (common)
  • Dissociation of mind from body
  • Sweating
  • Analgesia, numbness
  • Significant change in perception of time
  • Increase in heart rate
  • Confusion, disorientation


  • Risk of psychological dependency
  • Nasal discomfort upon insufflation
  • Blacking out and forgetting one has taken a drug
  • Discomfort, pain or numbness at injection site (with IM)
  • Severe confusion, disorganised thinking
  • Vertigo, spinning sensation (risk of injury)
  • Nausea, vomiting
  • Susceptibility to accidents (from uncoordination and change in perception of body and time)
  • Severe dissociation, depersonalisation
  • Loss of consciousness
  • Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)
  • Entity contact

Harm Reduction

A recent study on rats indicates that MXEMethoxetamine may have harmful effects on the cardiovascular system, and therefor should probably be avoided by anyone with any history of cardiovascular issues.

See Dissociative Harm Reduction for general information.


MXEMethoxetamine is extremely dangerous in combination with alcohol and can cause fatal apnea or respiratory depression. Even residual MXEMethoxetamine can potentiate the effects of 5ht agonists. Drug Combinations

Chemistry and Pharmacology

Examination of MXEMethoxetamine molecule showed that, similar to Ketamine, the 2 isomers have totally different effects with the (S) having potent NMDAN-methyl-D-aspartate receptor. NMDA antagonists are often dissociatives. activity (when the -OCH3 is deprotected to -OH, it gets stronger) while the (R) isomerEach of two or more compounds with the same formula but a different arrangement of atoms in the molecule and different properties. has SRISerotonin Reuptake Inhibitor effects and possibly a opioid metabolite.

MXEMethoxetamine is generally sold racemic.

Legal status

Methoxetamine is illegal in the US states Arizona[1], Florida[2], Indiana[3], Louisiana[4], Minnesota[5], North Dakota[6], Ohio[7] and Virginia[8]. It is also banned in Brazil, France, Germany, Japan, Russia and the UK[9].





/r/Drugs FAQ


  1. http://www.azleg.gov/DocumentsForBill.asp?Session_ID=112&Bill_Number=HB2453
  2. http://www.leg.state.fl.us/Statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html
  3. http://www.in.gov/legislative/ic/2010/title35/ar31.5/ch2.html
  4. http://www.legis.la.gov/legis/ViewDocument.aspx?d=850979&n=HB10%20Act
  5. https://www.revisor.mn.gov/statutes/?id=152.02
  6. http://www.legis.nd.gov/cencode/t19c03-1.pdf?20140721032549
  7. http://www.legislature.state.oh.us/BillText130/130_HB_315_RH_N.html
  8. http://lis.virginia.gov/cgi-bin/legp604.exe?000+cod+54.1-3446
  9. http://www.legislation.gov.uk/uksi/2013/239/contents/made

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