Methadone Revision as of 10:36, 20 June 2016 by Sleep (Talk | contribs) (diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)

Methadone is a synthetic opioid. It is most commonly used as a form of maintenance therapy or to help in detox, in people with dependence to opioids.

History

Methadone was developed in Germany in 1937 by Gustav Ehrhart and Max Bockmühl, that could be created with readily available precursors.

On September 11, 1941 Bockmühl and Ehrhart filed an application for a patent for a synthetic substance they called Polamidon, and whose structure had only a slight relation to morphine or other opiate alkaloids. It was brought to market in 1944 and was widely used by the German army during WWII.

Methadone was introduced into the United States in 1947 by Eli Lilly and Company, as an analgesic under the trade name Dolophine.

Dosage

Oral

Light	3-5 mg
Common	5-15 mg
Strong	15-30 mg+

NOTE: Do not stack this with more Methadone, as this substance takes fairly long to peak.

Duration

Oral

Onset	45-90 minutes
Total	6-12 hours

Effects

Positive

• Euphoria

• Pain relief

• Elevated mood

• Overall feeling of contentedness

Neutral

• Itching

Negative

• Nausea

• Constipation

• CNSCentral Nervous System depression

• Drowsiness

• Hot/cold flashes

• Dizziness

• Vomiting

• Urinary retention (difficulty urinating)

Harm Reduction

• Do not mix with Alcohol, Benzodiazepines, or other CNSCentral Nervous System depressants.

• Do not drive or operate heavy machinery.

Legal Status

• UK: Class A. (Illegal to produce, supply, or possess)

• United States: Schedule II (Illegal without a prescription)

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