* MDMA rapidly builds tolerance, depletes serotonin and compounds neurotoxicity issues. Look for other drugs and avoid using MDMA more than once every few months.
* Ecstasy tablets are notoriously impure, often containing chemicals other than MDMA. Check out [http://www.ecstasydata.org/ EcstasyData] and [http://pillreports.com/ Pill Reports] for pill testing results. Buy a [[Test Kit]]!
== Health risks ==
As with many drugs, there are some serious risks associated with taking MDMA affecting people with existing health conditions, or in certain cases people who are otherwise very healthy. It is not advisable to take MDMA if any of the following apply to you:
* Health issues with the Heart, Kidneys or Liver
* High blood pressure
* History of having a stroke or heart attack
In rare cases MDMA can cause seizures, overheating, hypothermia, dehydration or water poisoning. It is important to keep an eye on body temperature and hydration while under the effects of MDMA.
There are some studies which suggest that long-term overuse and abuse of MDMA can cause or increase depression.
=== Interactions ===
* MDMA can cause [[Serotonin Syndrome]] when combined with MAOIs. Refer to [[Drug combinations]] for more information.
* [http://www.erowid.org/chemicals/mdma/mdma_info9.shtml SSRIs and SNRIs block most effects of MDMA.]
== Chemistry and Pharmacology ==
=== Neurotoxicity, by Borax ===
* The neurotoxicity is [https://pay.reddit.com/r/drugs/wiki/mdmaneurotoxicity well established], but studies are largely on mice and rats with [http://www.bluelight.org/vb/threads/614514 higher dosages than humans tend to use].
* There is an excellent run through of the pharmacodynamics of MDMA neurotoxicity [http://www.dancesafe.org/drug-information/is-mdma-neurotoxic/ here].
* Overall what we know is that the neurotoxicity scales with dose, and is likely to do so exponentially as the body is caused to overheat more and has less anitoxidants to deal with metabolites.
* We don't have any quantitative estimates about damage from normal human doses because it would not be ethical to dose people repeatedly just to see how much it damages them, and it's very hard to gather data from regular users because of the huge number of variables like alcohol and cannabis use, sleep deprivation, environment of MDMA use etc.
* We know that long term users are not [http://jop.sagepub.com/content/24/2/175 mentally impaired] but those *abusing* the drug do show a reduced ability to enjoy it and suffer a more intense comedown, indicating that there is something going on at higher doses.
* Another discussion about MDMA neurotoxicity can be found [https://pay.reddit.com/r/Drugs/comments/12v5f8/research_suggests_no_neurotoxicity_in_mdma/c6ye9xc here].
=== MDMA purity myths, by Borax ===
The 84% claims are based around either a poor understanding of the science or are a deliberate attempt to pass off inferior product as high quality.
You should read [https://pay.reddit.com/r/Drugs/comments/xihdo/rdrugs_ama_series_mdma_aka_ecstasy_e_x_molly/c5moa3i this discussion], but basically if anyone claims their MDMA is 84% pure then they have performed no analysis at all and should not be trusted.
With almost all, the name is an abbreviation for Drug.salt. In the case of MDMA, it is MDMA.HCl, amphetamine is usually amphetamine.H2SO4 and LSD is LSD.tartrate. Because these forms are ubiquitous, nobody bothers to mention the second bit because it's irrelevant. All doses you see for MDMA are referring to the HCl salt, which means that MDMA which is sold as "the purest you can get, 84%", is treated as 100% pure.
The reason sellers do this is because they usually don't have very pure MDMA, and they want people to make the mistake you have made and take more to account for crappy product. It is dishonest, confusing and misleading and if you have a choice you should avoid this vendor.
=== Production ===
MDMA is generally synthesised from naturally occurring safrole, extracted from the sassafras tree, making it a semi-synthetic drug.
== Legal Status ==
MDMA is legally controlled in most of the world under the UN Convention on Psychotropic Substances and other international agreements, although exceptions exist for research and limited medical use. In general, the unlicensed use, sale or manufacture of MDMA are all criminal offences.
== Images ==
<gallery mode="packed-hover">
Image:Mdma.jpg|''MDMA Crystals''
Image:Mdma2.jpg|''MDMA Crystals''
Image:Bitcoin.png|''Bitcoin MDMA Pill''
Image:Mdma3.png|''MDMA Crystals''
Image:Mdma7.jpg|''MDMA Crystals''
</gallery>
== Links ==
[https://pay.reddit.com/r/Borax/comments/w5c1x/a_stepbystep_guide_to_reducing_mdma_neurotoxicity/ A step-by-step guide to reducing MDMA neurotoxicity]
[https://pay.reddit.com/r/drugs/wiki/mdmaneurotoxicity Studies on MDMA neurotoxicity]
MDMA (3,4-methylenedioxy-N-Methylamphetamine) is an popular drug of the phenethylamine and amphetamine class known for its empathogenic, euphoric, and stimulant effects, and has also been used in psychotherapy. It most frequently comes in tablet form, although it is also found in capsules or as powder. MDMA is also known as Ecstasy, Molly, XTC, E and several other names.
Because MDMA is so popular and because it goes well with dance parties, the demand for it usually exceeds supply, especially at any given location on any given night. This creates an opening for unscrupulous individuals to sell virtually anything as 'ecstasy'. While 'ecstasy' is the popular name for MDMA, the functional definition of ecstasy is any pill represented as MDMA on the street. Ecstasy pills are notoriously unreliable in content, more so than most other street drugs, and commonly contain either caffeine, ephedrine, amphetamines, other MDXX's, DXM, or in rare cases DOX's, and don't necessarily contain MDMA or any psychoactive. They can also contain very neurotoxic substances (such as PMA, 4-CA, among many others). This problem has led to the development of simple MDMA Test Kits that may help give the user a general sense of the content of a pill.
