Drug combinations
WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times!
File:TripSitDrugComboChart.gif
Chart versions[edit | edit source]
General information[edit | edit source]
Substance class description[edit | edit source]
Psychedelics[edit | edit source]
- 2C-T-x is a moderate MAO-A inhibitor, can cause Serotonin Syndrome when combined with monoamine releasers, SSRIs or other MAO inhibitors.
- αMT is a reversible MAOI in higher doses (the danger rises exponentially as αMT doses approach 150 mg due to increased monoamine release and increased MAO inhibition), can cause Serotonin Syndrome when combined with monoamine releasers, SSRIs or other MAO inhibitors.
- 5-MeO substituted tryptamines are SNRIs or SNDRIs and therefore should not be combined with other reuptake inhibitors or MAOIs.
Specific combinations with references (work in progress)[edit | edit source]
LSD & DMT[edit | edit source]
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
LSD & GHB/GBL[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16483730
LSD & Opioids[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/547279
http://www.ncbi.nlm.nih.gov/pubmed/3006089
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
LSD & Tramadol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/3006089
LSD & MAOIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/8788508
http://www.ncbi.nlm.nih.gov/pubmed/108709
https://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2439&DocPartID=2199
LSD & SSRIs[edit | edit source]
http://www.nature.com/npp/journal/v14/n6/full/1380431a.html
http://www.ncbi.nlm.nih.gov/pubmed/8726753
DMT & Opioids[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/3006089
DMT & Tramadol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/3006089
DOx & Amphetamines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/1208759
Ketamine & Caffeine[edit | edit source]
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full
Ketamine & Alcohol[edit | edit source]
http://onlinelibrary.wiley.com/doi/10.1002/jemt.22045/abstract
Ketamine & GHB/GBL[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16483730
Ketamine & Opioids[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/21224020
MXE & DXM[edit | edit source]
http://www.sciencedirect.com/science/article/pii/S0014488607002543
MXE & Amphetamines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/25060403
DXM & PCP[edit | edit source]
http://www.sciencedirect.com/science/article/pii/S0014488607002543
PCP & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224745/
Amphetamines & Benzodiazepines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/17320309 (says unsafe :O )
MDMA & Caffeine[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/22671762
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02065.x/full
http://link.springer.com/article/10.1007/s00213-010-1864-1
http://www.sciencedirect.com/science/article/pii/S0028390805003114
MDMA & Alcohol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/21040238
http://www.ncbi.nlm.nih.gov/pubmed/21756931
MDMA & GHB/GBL[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16234132
http://www.ncbi.nlm.nih.gov/pubmed/22554869
http://www.ncbi.nlm.nih.gov/pubmed/20730418
http://www.ncbi.nlm.nih.gov/pubmed/16483730
Cocaine & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/23761390
http://www.ncbi.nlm.nih.gov/pubmed/20195220
Caffeine & Alcohol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/20001110
Caffeine & Tramadol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/20837047
Caffeine & SSRIs[edit | edit source]
Alcohol & GHB/GBL[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/15274975
Alcohol & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/15739105
GHB/GBL & Opioids[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/7782758
GHB/GBL & Tramadol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/7782758
GHB/GBL & Benzodiazepines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16483730
GHB/GBL & MAOIs[edit | edit source]
No study, but MAO B inhibitors should enhance the effects, no interaction with MAO A.
Opioids & Benzodiazepines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454351/
Opioids & MAOIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/17157368 (?)
http://www.ncbi.nlm.nih.gov/pubmed/2891392
http://www.if-pan.krakow.pl/pjp/pdf/2013/3_593.pdf
Opioids & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/23391344
http://www.ncbi.nlm.nih.gov/pubmed/20513454
http://www.ncbi.nlm.nih.gov/pubmed/16005413
http://www.ncbi.nlm.nih.gov/pubmed/18676387
http://www.ncbi.nlm.nih.gov/pubmed/17381671
Tramadol & Benzodiazepines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/12842359
Tramadol & MAOIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16051647
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
Tramadol & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
Benzodiazepines & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446479/
http://www.ncbi.nlm.nih.gov/pubmed/9435993
