GrimReaper (Talk | contribs) |
|||
| Line 1: | Line 1: | ||
'''WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times! ''' | '''WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times! ''' | ||
| − | [[File: | + | [[File:TripSitDrugComboChart.gif|1000px|center]] |
== Overview == | == Overview == | ||
WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times!
If you want to give us some feedback/recommendation/comment on the chart, you can contact us:
Email: content@tripsit.me, or email GrimReaper directly at grimreaper@tripsit.me
The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops
High doses of caffeine are uncomfortable and this will be magnified by psychedelics
The 5-MeO class of tryptamines can be unpredictable in their interactions
This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures.
The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
Ketamine and psychedelics tend to potentiate each other - go slowly.
As an NMDAN-methyl-D-aspartate receptor. NMDA antagonists are often dissociatives. antagonistA substance that interferes with or inhibits the physiological action of another. MXEMethoxetamine potentiates DOx which can be unpleasantly intense
The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
No unexpected interactions.
Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
The 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. are known to be unpredictable even alone. This combination is best avoided
Amphetamines and NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. are known to cause seizures and stimulants can increase this risk.
Cocaine and NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
Caffiene can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle while tripping
Tramadol is well known to lower seizure threshold and NBOMesN-Benzyl-Ortho-Methoxy derivatives of psychedelic phenethylamines. have also shown a tendency to cause severe seizures
The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Both these classes of compound can interact unpredictably. Caution should be exercised.
No expected interactions, some Opioids have SerotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. action, and could lead to SerotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol.
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
aMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable
No unexpected interactions
The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care
The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
No unexpected interactions. Likely to increase blood pressure but not an issue with sensible doses
No unexpected interactions.
Both substances cause ataxiaLoss of motor coordination and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Both substances cause ataxiaLoss of motor coordination and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
No unexpected interactions
Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
Risk of tachycardia, hypertension, and manic states
There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXEMethoxetamine taken to the end of an MDMA experience does not appear to cause the same issues.
Stimulants taken with MXEMethoxetamine can lead to hypermanic states much more easily, especially if sleep is avoided.
No likely interactions
There is a high risk of memory loss, vomiting and severe ataxiaLoss of motor coordination from this combination.
Both substances cause ataxiaLoss of motor coordination and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
This combination can potentiate the effects of the opioid
Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess.
Depending on the SSRISelective Serotonin Reuptake Inhibitor this combination can be unpredictable
Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
High risk of serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. syndrome
Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues
High risk of serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. syndrome.
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Additionally CNSCentral Nervous System depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau.
Both substances cause ataxiaLoss of motor coordination and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. This combination is hard to predict
CNSCentral Nervous System depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally, there is a reverse cross tolerance between opiates/dxm. I.E. if one takes dxm, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.
Small doses of benzos can end a bad trip, but both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and this can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
This combination can easily lead to hypermanic states
This combination can easily lead to hypermanic states
This combination can easily lead to hypermanic states
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
PCP can reduce opioid tolerance, increasing the risk of overdose
Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
This combination can lead to vomiting
Amphetamines increase the neurotoxic effects of MDMA
This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamineA neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system. releasers like amphetamine
This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.
Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Tramadol and stimulants both increase the risk of seizures.
Cocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.
Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA
Both MDMA and alcohol cause severe dehydration. Approach this combination with caution, moderation and sufficient hydration.
Tramadol and stimulants both increase the risk of seizures.
Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.
Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel he alcohol less. Cocaine is potentiated somewhat by alcohol because of the formation of cocaethylene.
Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. Likewise the G can wear off and leave a dangerous concentration of cocaine behind
Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Tramadol and stimulants both increase the risk of seizures.
Risk of serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. syndrome, Likely to make the SSRISelective Serotonin Reuptake Inhibitor's innefective with regular cocaine use. The SSRIs may also make the cocaine less effective. Mental stability and cocaine don't go together
Even in very low doses this combination rapidly leads to memory loss, severe ataxiaLoss of motor coordination and unconsciousness. There is a high risk of vomit aspiration while unconscious.
Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely
Heavy CNSCentral Nervous System depressants, risk of seizures. Both substances potentiate the ataxiaLoss of motor coordination and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.
Ethanol ingestion may potentiate the CNSCentral Nervous System effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.
The chemical tyramine in alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.
Alcohol may potentiate some of the pharmacologic effects of CNSCentral Nervous System-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position
The sedative effects of this combination can lead to dangerous respiratory depression.
The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present
Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely
Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.
Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present. Vomit aspiration a risk when passed out, lay down in recovery position if ingested.
http://www.ncbi.nlm.nih.gov/pubmed/3006089 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
http://www.ncbi.nlm.nih.gov/pubmed/16483730
http://www.ncbi.nlm.nih.gov/pubmed/547279
http://www.ncbi.nlm.nih.gov/pubmed/3006089
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://www.ncbi.nlm.nih.gov/pubmed/8788508
http://www.ncbi.nlm.nih.gov/pubmed/108709
https://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2439&DocPartID=2199
http://www.nature.com/npp/journal/v14/n6/full/1380431a.html
http://www.ncbi.nlm.nih.gov/pubmed/8726753
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://www.ncbi.nlm.nih.gov/pubmed/16234132
http://www.ncbi.nlm.nih.gov/pubmed/22554869
http://www.ncbi.nlm.nih.gov/pubmed/20730418
http://www.ncbi.nlm.nih.gov/pubmed/16483730
http://www.ncbi.nlm.nih.gov/pubmed/1208759
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full
http://onlinelibrary.wiley.com/doi/10.1002/jemt.22045/abstract
http://www.ncbi.nlm.nih.gov/pubmed/16483730
http://www.ncbi.nlm.nih.gov/pubmed/21224020
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
http://www.sciencedirect.com/science/article/pii/S0014488607002543
http://www.ncbi.nlm.nih.gov/pubmed/25060403
http://www.sciencedirect.com/science/article/pii/S0014488607002543
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224745/
http://www.ncbi.nlm.nih.gov/pubmed/17320309
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492978/
http://link.springer.com/article/10.1007/s00213-010-1864-1
http://www.sciencedirect.com/science/article/pii/S0028390805003114
http://www.ncbi.nlm.nih.gov/pubmed/24211539
http://www.ncbi.nlm.nih.gov/pubmed/21040238
http://www.ncbi.nlm.nih.gov/pubmed/21756931
http://www.ncbi.nlm.nih.gov/pubmed/23761390
http://www.ncbi.nlm.nih.gov/pubmed/20195220
http://www.ncbi.nlm.nih.gov/pubmed/20001110
http://www.ncbi.nlm.nih.gov/pubmed/20837047
http://www.ncbi.nlm.nih.gov/pubmed/15274975
http://www.ncbi.nlm.nih.gov/pubmed/15739105
http://www.ncbi.nlm.nih.gov/pubmed/7782758
http://www.ncbi.nlm.nih.gov/pubmed/7782758
http://www.ncbi.nlm.nih.gov/pubmed/16483730
No study, but MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). B inhibitors should enhance the effects, no interaction with MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). A.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454351/
http://www.ncbi.nlm.nih.gov/pubmed/17157368 (?)
http://www.ncbi.nlm.nih.gov/pubmed/2891392
http://www.if-pan.krakow.pl/pjp/pdf/2013/3_593.pdf
http://www.ncbi.nlm.nih.gov/pubmed/23391344
http://www.ncbi.nlm.nih.gov/pubmed/20513454
http://www.ncbi.nlm.nih.gov/pubmed/16005413
http://www.ncbi.nlm.nih.gov/pubmed/18676387
http://www.ncbi.nlm.nih.gov/pubmed/17381671
http://www.ncbi.nlm.nih.gov/pubmed/12842359
http://www.ncbi.nlm.nih.gov/pubmed/16051647
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446479/
http://www.ncbi.nlm.nih.gov/pubmed/9435993
http://www.ncbi.nlm.nih.gov/pubmed/24577320
