Revision as of 13:40, 20 September 2014

WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times!

1000px

Chart versions

English

Portuguese

German

Polish

General information

Substance class description

Psychedelics

2C-T-x is a moderate MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-A inhibitor, can cause SerotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. Syndrome when combined with monoamine releasers, SSRIs or other MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). inhibitors.
- https://www.ncbi.nlm.nih.gov/pubmed/15801832

αMT is a reversible MAOIMonoamine oxidase inhibitor are drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate. in higher doses (the danger rises exponentially as αMT doses approach 150 mg due to increased monoamine release and increased MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). inhibition), can cause SerotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. Syndrome when combined with monoamine releasers, SSRIs or other MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). inhibitors.

5-MeO substituted tryptamines are SNRIs or SNDRIs and therefore should not be combined with other reuptake inhibitors or MAOIs.

Specific combinations with references (work in progress)

LSD & DMT

"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."

http://www.ncbi.nlm.nih.gov/pubmed/3006089

http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf

LSD & GHB/GBL

http://www.ncbi.nlm.nih.gov/pubmed/16483730

LSD & Opioids

http://www.ncbi.nlm.nih.gov/pubmed/547279

http://www.ncbi.nlm.nih.gov/pubmed/3006089

"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."

http://www.ncbi.nlm.nih.gov/pubmed/3006089

http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf

GHB/GBL & MAOIs

No study, but MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). B inhibitors should enhance the effects, no interaction with MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). A.

Opioids & Benzodiazepines

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454351/

Opioids & MAOIs

http://www.ncbi.nlm.nih.gov/pubmed/17157368 (?)

http://www.ncbi.nlm.nih.gov/pubmed/2891392

http://www.if-pan.krakow.pl/pjp/pdf/2013/3_593.pdf

Opioids & SSRIs

http://www.ncbi.nlm.nih.gov/pubmed/23391344

http://www.ncbi.nlm.nih.gov/pubmed/20513454

http://www.ncbi.nlm.nih.gov/pubmed/16005413

http://www.ncbi.nlm.nih.gov/pubmed/18676387

http://www.ncbi.nlm.nih.gov/pubmed/17381671

Tramadol & Benzodiazepines

http://www.ncbi.nlm.nih.gov/pubmed/12842359

Tramadol & MAOIs

http://www.ncbi.nlm.nih.gov/pubmed/16051647

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/

Tramadol & SSRIs

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/

Benzodiazepines & SSRIs

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446479/

http://www.ncbi.nlm.nih.gov/pubmed/9435993

MAOIs & SSRIs

http://www.ncbi.nlm.nih.gov/pubmed/24577320

Top Contributors

GrimReaper, Roi, Reality, Borax, TripMate, Robustrepresent, Bjorn, Sleep and Anonymous

@@ Line 35: / Line 35: @@
 = Specific combinations with references (work in progress) =
-===LSD + DMT===
+===LSD & DMT===
 "Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
@@ Line 41: / Line 41: @@
 http://www.ncbi.nlm.nih.gov/pubmed/3006089
-http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf?sequence=1
+http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
-===LSD + GHB/GBL===
+===LSD & GHB/GBL===
 http://www.ncbi.nlm.nih.gov/pubmed/16483730
-===LSD + Opioids===
+===LSD & Opioids===
 http://www.ncbi.nlm.nih.gov/pubmed/547279
@@ Line 55: / Line 55: @@
 "Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
-http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf?sequence=1
+http://www.ncbi.nlm.nih.gov/pubmed/3006089
+http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
-===LSD + Tramadol===
+===LSD & Tramadol===
 http://www.ncbi.nlm.nih.gov/pubmed/3006089
-===LSD + MAOIs===
+===LSD & MAOIs===
 http://www.ncbi.nlm.nih.gov/pubmed/8788508
@@ Line 69: / Line 71: @@
 https://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2439&DocPartID=2199
-===LSD + SSRIs===
+===LSD & SSRIs===
 http://www.nature.com/npp/journal/v14/n6/full/1380431a.html
@@ Line 75: / Line 77: @@
 http://www.ncbi.nlm.nih.gov/pubmed/8726753
-===DMT + Opioids===
+===DMT & Opioids===
 http://www.ncbi.nlm.nih.gov/pubmed/3006089
-===DMT + Tramadol===
+===DMT & Tramadol===
 http://www.ncbi.nlm.nih.gov/pubmed/3006089
-===DOx + Amphetamines===
+===DOx & Amphetamines===
 http://www.ncbi.nlm.nih.gov/pubmed/1208759
-===Ibogaine + PCP===
+===Ketamine & Caffeine===
-http://www.ncbi.nlm.nih.gov/pubmed/9477000
+http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full
-===Ibogaine + Amphetamines===
+===Ketamine & Alcohol===
-http://www.ncbi.nlm.nih.gov/pubmed/1393568 (Increase)
-http://www.ncbi.nlm.nih.gov/pubmed/9475618
-===Ibogaine + Cocaine===
-(Increase) http://www.ncbi.nlm.nih.gov/pubmed/1601069
-http://www.ncbi.nlm.nih.gov/pubmed/11085337
-http://www.ncbi.nlm.nih.gov/pubmed/10463325
-===Ibogaine + Opioids===
-(Non SNRIs) http://www.ncbi.nlm.nih.gov/pubmed/1393568
-(Non SNRIs) http://www.ncbi.nlm.nih.gov/pubmed/1893925
-(Non SNRIs) http://www.ncbi.nlm.nih.gov/pubmed/1868880
-===Ketamine + Amphetamines===
-http://www.ncbi.nlm.nih.gov/pubmed/23660488
-===Ketamine + Caffeine===
-http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full
-===Ketamine + Alcohol===
 http://onlinelibrary.wiley.com/doi/10.1002/jemt.22045/abstract
-===Ketamine + GHB/GBL===
+===Ketamine & GHB/GBL===
 http://www.ncbi.nlm.nih.gov/pubmed/16483730
-===Ketamine + Opioids===
+===Ketamine & Opioids===
 http://www.ncbi.nlm.nih.gov/pubmed/21224020
-===MXE + DXM===
+===MXE & DXM===
 http://i.imgur.com/zmqaw.jpg
@@ Line 136: / Line 111: @@
 http://www.sciencedirect.com/science/article/pii/S0014488607002543
-===DXM  + PCP===
+===MXE & Amphetamines===
+http://www.ncbi.nlm.nih.gov/pubmed/25060403
+===DXM  & PCP===
 http://i.imgur.com/zmqaw.jpg
@@ Line 142: / Line 121: @@
 http://www.sciencedirect.com/science/article/pii/S0014488607002543
-===PCP + SSRIs===
+===PCP & SSRIs===
 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224745/
-===Amphetamines + GHB/GBL===
+===Amphetamines & Benzodiazepines===
-http://www.ncbi.nlm.nih.gov/pubmed/22554869
+http://www.ncbi.nlm.nih.gov/pubmed/17320309 (says unsafe :O )
-===Amphetamines + Benzodiazepines===
+===MDMA & Caffeine===
-http://www.ncbi.nlm.nih.gov/pubmed/17320309
-===MDMA + Caffeine===
 http://www.ncbi.nlm.nih.gov/pubmed/22671762
@@ Line 160: / Line 135: @@
 http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02065.x/full
-http://link.springer.com/article/10.1007/s00213-010-1864-1#page-1
+http://link.springer.com/article/10.1007/s00213-010-1864-1
 http://www.sciencedirect.com/science/article/pii/S0028390805003114
-===MDMA + GHB/GBL===
+===MDMA & Alcohol===
+http://www.ncbi.nlm.nih.gov/pubmed/21040238
+http://www.ncbi.nlm.nih.gov/pubmed/21756931
+===MDMA & GHB/GBL===
 http://www.ncbi.nlm.nih.gov/pubmed/16234132
@@ Line 174: / Line 155: @@
 http://www.ncbi.nlm.nih.gov/pubmed/16483730
-===Cocaine + SSRIs===
+===Cocaine & SSRIs===
 http://www.ncbi.nlm.nih.gov/pubmed/23761390
 http://www.ncbi.nlm.nih.gov/pubmed/20195220
-===Caffeine + Alcohol===
+===Caffeine & Alcohol===
 http://www.ncbi.nlm.nih.gov/pubmed/20001110
-===Caffeine + Tramadol===
+===Caffeine & Tramadol===
 http://www.ncbi.nlm.nih.gov/pubmed/20837047
-===Caffeine + SSRIs===
+===Caffeine & SSRIs===
 http://journals.lww.com/jpharmacogenetics/abstract/1996/06000/a_fluvoxamine_caffeine_interaction_study.3.aspx
-===Alcohol + GHB/GBL===
+===Alcohol & GHB/GBL===
 http://www.ncbi.nlm.nih.gov/pubmed/15274975
-===Alcohol + SSRIs===
+===Alcohol & SSRIs===
 http://www.ncbi.nlm.nih.gov/pubmed/15739105
-===GHB/GBL + Opioids===
+===GHB/GBL & Opioids===
 http://www.ncbi.nlm.nih.gov/pubmed/7782758
-===GHB/GBL + Tramadol===
+===GHB/GBL & Tramadol===
 http://www.ncbi.nlm.nih.gov/pubmed/7782758
-===GHB/GBL + Benzodiazepines===
+===GHB/GBL & Benzodiazepines===
 http://www.ncbi.nlm.nih.gov/pubmed/16483730
-===GHB/GBL + MAOIs===
+===GHB/GBL & MAOIs===
 No study, but MAO B inhibitors should enhance the effects, no interaction with MAO A.
-===Opioids + Benzodiazepines===
+===Opioids & Benzodiazepines===
 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454351/
-===Opioids + MAOIs===
+===Opioids & MAOIs===
-http://www.ncbi.nlm.nih.gov/pubmed/17157368
+http://www.ncbi.nlm.nih.gov/pubmed/17157368 (?)
 http://www.ncbi.nlm.nih.gov/pubmed/2891392
@@ Line 226: / Line 209: @@
 http://www.if-pan.krakow.pl/pjp/pdf/2013/3_593.pdf
-===Opioids + SSRIs===
+===Opioids & SSRIs===
 http://www.ncbi.nlm.nih.gov/pubmed/23391344
@@ Line 238: / Line 221: @@
 http://www.ncbi.nlm.nih.gov/pubmed/17381671
-===Tramadol + Benzodiazepines===
+===Tramadol & Benzodiazepines===
 http://www.ncbi.nlm.nih.gov/pubmed/12842359
-===Tramadol + MAOIs===
+===Tramadol & MAOIs===
 http://www.ncbi.nlm.nih.gov/pubmed/16051647
@@ Line 248: / Line 231: @@
 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
-===Tramadol + SSRIs===
+===Tramadol & SSRIs===
 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/
@@ Line 254: / Line 237: @@
 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
-===Benzodiazepines + SSRIs===
+===Benzodiazepines & SSRIs===
 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446479/
@@ Line 260: / Line 243: @@
 http://www.ncbi.nlm.nih.gov/pubmed/9435993
-===MAOIs + SSRIs===
+===MAOIs & SSRIs===
 http://www.ncbi.nlm.nih.gov/pubmed/24577320

Difference between revisions of "Drug combinations"

Revision as of 13:40, 20 September 2014

Contents

Chart versions

General information

Substance class description

Psychedelics

Specific combinations with references (work in progress)

LSD & DMT

LSD & GHB/GBL

LSD & Opioids

LSD & Tramadol

LSD & MAOIs

LSD & SSRIs

DMT & Opioids

DMT & Tramadol

DOx & Amphetamines

Ketamine & Caffeine

Ketamine & Alcohol

Ketamine & GHB/GBL

Ketamine & Opioids

MXEMethoxetamine & DXM

MXEMethoxetamine & Amphetamines

DXM & PCP

PCP & SSRIs

Amphetamines & Benzodiazepines

MDMA & Caffeine

MDMA & Alcohol

MDMA & GHB/GBL

Cocaine & SSRIs

Caffeine & Alcohol

Caffeine & Tramadol

Caffeine & SSRIs

Alcohol & GHB/GBL

Alcohol & SSRIs

GHB/GBL & Opioids

GHB/GBL & Tramadol

GHB/GBL & Benzodiazepines

GHB/GBL & MAOIs

Opioids & Benzodiazepines

Opioids & MAOIs

Opioids & SSRIs

Tramadol & Benzodiazepines

Tramadol & MAOIs

Tramadol & SSRIs

Benzodiazepines & SSRIs

MAOIs & SSRIs

Top Contributors