Drug combinations: Difference between revisions
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=== Amphetamine & Mescaline === | === Amphetamine & Mescaline === | ||
The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops | The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops. | ||
=== Cocaine & Mescaline === | === Cocaine & Mescaline === | ||
The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops | The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops. | ||
=== Caffeine & Mescaline === | === Caffeine & Mescaline === | ||
High doses of caffeine are uncomfortable and this will be magnified by psychedelics | High doses of caffeine are uncomfortable and this will be magnified by psychedelics. | ||
=== 5- | === 5-MeO-xxT & Mescaline === | ||
The 5-MeO class of tryptamines can be unpredictable in their interactions | The 5-MeO class of tryptamines can be unpredictable in their interactions. | ||
=== Tramadol & Mescaline === | === Tramadol & Mescaline === | ||
This combination can cause seizures due to the lowering | This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures. | ||
=== 5- | === 5-MeO-xxT & DOx === | ||
The | The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects. | ||
=== Ketamine & | === Ketamine & DOx === | ||
Ketamine and psychedelics tend to potentiate each other - go slowly. | Ketamine and psychedelics tend to potentiate each other - go slowly. | ||
=== MXE & | === MXE & DOx === | ||
As an NMDA antagonist MXE | As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense. | ||
=== DXM & | === DXM & DOx === | ||
The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience. | The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience. | ||
=== PCP & | === PCP & DOx === | ||
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner. | Details of this combination are not well understood but PCP generally interacts in an unpredictable manner. | ||
=== Amphetamine & | === Amphetamine & DOx === | ||
The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic. | The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic. | ||
=== MDMA & | === MDMA & DOx === | ||
The | The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic. | ||
=== Cocaine & | === Cocaine & DOx === | ||
The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic | The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic. | ||
=== Caffeine & | === Caffeine & DOx === | ||
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort. | High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort. | ||
=== Alcohol & | === Alcohol & DOx === | ||
Drinking | Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. | ||
=== Opioids & | === Opioids & DOx === | ||
No unexpected interactions. | No unexpected interactions. | ||
=== Tramadol & | === Tramadol & DOx === | ||
Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures. | Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures. | ||
=== 5- | === 5-MeO-xxT & NBOMes === | ||
The | The 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMes are known to be unpredictable even alone. This combination is best avoided. | ||
=== Amphetamine & | === Amphetamine & NBOMes === | ||
Amphetamines and NBOMes both provide considerable | Amphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk. | ||
=== Cocaine & | === Cocaine & NBOMes === | ||
Cocaine and NBOMes both provide considerable stimulation. | Cocaine and NBOMes both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure. | ||
=== Caffeine & | === Caffeine & NBOMes === | ||
Caffiene can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle while tripping | Caffiene can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle while tripping. | ||
=== Tramadol & | === Tramadol & NBOMes === | ||
Tramadol is well known to lower seizure threshold and NBOMes have also shown a tendency to cause severe seizures | Tramadol is well known to lower seizure threshold and NBOMes have also shown a tendency to cause severe seizures. | ||
=== 5- | === 5-MeO-xxT & 2c-x === | ||
The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics | The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics. | ||
=== Amphetamine & 2c-x === | === Amphetamine & 2c-x === | ||
The anxiogenic and focusing effects of stimulants increase the chance of | The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable. | ||
=== Cocaine & 2c-x === | === Cocaine & 2c-x === | ||
The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary | The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable. | ||
=== Caffeine & 2c-x === | === Caffeine & 2c-x === | ||
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Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures. | Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures. | ||
=== Caffeine & | === Caffeine & 2C-T-x === | ||
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort. | High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort. | ||
=== Alcohol & | === Alcohol & 2C-T-x === | ||
Both these classes of compound can interact unpredictably. Caution should be exercised. | Both these classes of compound can interact unpredictably. Caution should be exercised. | ||
=== Opioids & | === Opioids & 2C-T-x === | ||
No expected interactions, some Opioids have Serotonin action, and could lead to Serotonin Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol. | No expected interactions, some Opioids have Serotonin action, and could lead to Serotonin Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol. | ||
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=== Alcohol & αMT === | === Alcohol & αMT === | ||
αMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable. | |||
=== Opioids & αMT === | === Opioids & αMT === | ||
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No unexpected interactions | No unexpected interactions | ||
=== Amphetamine & 5- | === Amphetamine & 5-MeO-xxT === | ||
The anxiogenic and focusing effects of stimulants increase the chance of | The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. | ||
=== MDMA & 5- | === MDMA & 5-MeO-xxT === | ||
Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care | Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care. | ||
=== Cocaine & 5- | === Cocaine & 5-MeO-xxT === | ||
The anxiogenic and focusing effects of stimulants increase the chance of | The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. | ||
=== Amphetamine & Ketamine === | === Amphetamine & Ketamine === | ||
Amphetamine worsens Ketamines ataxia. | |||
=== Caffeine & Ketamine === | === Caffeine & Ketamine === | ||
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=== Alcohol & Ketamine === | === Alcohol & Ketamine === | ||
Both substances cause ataxia and bring a very high risk | Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. | ||
=== | === GHB/GBL & Ketamine === | ||
Both | Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. | ||
=== Opioids & Ketamine === | === Opioids & Ketamine === | ||
Both substances bring a risk of vomiting and unconsciousness. If the user | Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. | ||
=== Tramadol & Ketamine === | === Tramadol & Ketamine === | ||
No unexpected interactions | No unexpected interactions. | ||
=== Benzodiazepines & Ketamine === | === Benzodiazepines & Ketamine === | ||
Both | Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. | ||
=== Amphetamine & MXE === | === Amphetamine & MXE === | ||
Risk of tachycardia, hypertension, and manic states | Risk of tachycardia, hypertension, and manic states. | ||
=== MDMA & MXE === | === MDMA & MXE === | ||
There | There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues. | ||
=== Cocaine & MXE === | === Cocaine & MXE === | ||
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=== Caffeine & MXE === | === Caffeine & MXE === | ||
No likely interactions | No likely interactions. | ||
=== Alcohol & MXE === | === Alcohol & MXE === | ||
There is a high risk of memory loss, vomiting and severe ataxia from this combination. | There is a high risk of memory loss, vomiting and severe ataxia from this combination. | ||
=== | === GHB/GBL & MXE === | ||
Both | Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. | ||
=== Opioids & MXE === | === Opioids & MXE === | ||
This combination can potentiate the effects of the opioid | This combination can potentiate the effects of the opioid. | ||
=== Benzodiazepines & MXE === | === Benzodiazepines & MXE === | ||
Both | Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. | ||
=== | === SSRIs & MXE === | ||
Depending on the SSRI this combination can be unpredictable | Depending on the SSRI this combination can be unpredictable. | ||
=== Amphetamine & DXM === | === Amphetamine & DXM === | ||
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Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues. | Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues. | ||
=== | === MAOIs & DXM === | ||
High risk of serotonin syndrome | High risk of serotonin syndrome. | ||
=== Cocaine & DXM === | === Cocaine & DXM === | ||
Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues | Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues. | ||
=== | === SSRIs & DXM === | ||
High risk of serotonin syndrome. | High risk of serotonin syndrome. | ||
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=== Alcohol & DXM === | === Alcohol & DXM === | ||
Both | Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Additionally CNS depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau. | ||
=== | === GHB/GBL & DXM === | ||
Both | Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. This combination is hard to predict. | ||
=== Opioids & DXM === | === Opioids & DXM === | ||
CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally, | CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally, there is a reverse cross tolerance between opiates/dxm. I.E. if one takes dxm, their tolerance of opiates goes down slightly, thus causing additional synergistic effects. | ||
=== Benzodiazepines & DXM === | === Benzodiazepines & DXM === | ||
Small doses of benzos can end a bad trip, | Small doses of benzos can end a bad trip, but both substances potentiate the ataxia and sedation caused by the other and this can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. | ||
=== Amphetamine & PCP === | === Amphetamine & PCP === | ||
This combination can easily lead to hypermanic states | This combination can easily lead to hypermanic states. | ||
=== MDMA & PCP === | === MDMA & PCP === | ||
This combination can easily lead to hypermanic states | This combination can easily lead to hypermanic states. | ||
=== Cocaine & PCP === | === Cocaine & PCP === | ||
This combination can easily lead to hypermanic states | This combination can easily lead to hypermanic states. | ||
=== Caffeine & PCP === | === Caffeine & PCP === | ||
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Details of this combination are not well understood but PCP generally interacts in an unpredictable manner. | Details of this combination are not well understood but PCP generally interacts in an unpredictable manner. | ||
=== | === GHB/GBL & PCP === | ||
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner. | Details of this combination are not well understood but PCP generally interacts in an unpredictable manner. | ||
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=== Opioids & PCP === | === Opioids & PCP === | ||
PCP can reduce opioid tolerance, increasing the risk of overdose | PCP can reduce opioid tolerance, increasing the risk of overdose. | ||
=== Benzodiazepines & PCP === | === Benzodiazepines & PCP === | ||
Both substances potentiate the ataxia and sedation caused by the other and | Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely. | ||
=== | === SSRIs & PCP === | ||
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner. | Details of this combination are not well understood but PCP generally interacts in an unpredictable manner. | ||
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=== Alcohol & N2O === | === Alcohol & N2O === | ||
This combination can lead to vomiting | This combination can lead to vomiting. | ||
=== MDMA & Amphetamine === | === MDMA & Amphetamine === | ||
Amphetamines increase the neurotoxic effects of MDMA | Amphetamines increase the neurotoxic effects of MDMA. | ||
=== Cocaine & Amphetamine === | === Cocaine & Amphetamine === | ||
This | This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine. | ||
=== Caffeine & Amphetamine === | === Caffeine & Amphetamine === | ||
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=== Alcohol & Amphetamine === | === Alcohol & Amphetamine === | ||
Drinking | Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover. | ||
=== | === GHB/GBL & Amphetamine === | ||
Stimulants increase respiration rate allowing a higher dose of sedatives. If the | Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. | ||
=== Opioids & Amphetamine === | === Opioids & Amphetamine === | ||
Stimulants increase respiration rate allowing a higher dose of opiates. If the | Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. | ||
=== Tramadol & Amphetamine === | === Tramadol & Amphetamine === | ||
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=== Caffeine & MDMA === | === Caffeine & MDMA === | ||
Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA | Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA. | ||
=== Alcohol & MDMA === | === Alcohol & MDMA === | ||
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=== Caffeine & Cocaine === | === Caffeine & Cocaine === | ||
Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure. | Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure. | ||
=== Alcohol & Cocaine === | === Alcohol & Cocaine === | ||
Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel he alcohol less. Cocaine is potentiated somewhat by alcohol because of the formation of cocaethylene. | Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel he alcohol less. Cocaine is potentiated somewhat by alcohol because of the formation of cocaethylene. | ||
=== | === GHB/GBL & Cocaine === | ||
Stimulants increase respiration rate allowing a higher dose of sedatives. If the | Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. Likewise the G can wear off and leave a dangerous concentration of cocaine behind. | ||
=== Opioids & Cocaine === | === Opioids & Cocaine === | ||
Stimulants increase respiration rate allowing a higher dose of opiates. If the | Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. | ||
=== Tramadol & Cocaine === | === Tramadol & Cocaine === | ||
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Tramadol and stimulants both increase the risk of seizures. | Tramadol and stimulants both increase the risk of seizures. | ||
=== | === SSRIs & Cocaine === | ||
Risk of serotonin syndrome, Likely to make the SSRI's innefective with regular cocaine use. The SSRIs may also make the cocaine less effective. Mental stability and cocaine don't go together | Risk of serotonin syndrome, Likely to make the SSRI's innefective with regular cocaine use. The SSRIs may also make the cocaine less effective. Mental stability and cocaine don't go together. | ||
=== | === GHB/GBL & Alcohol === | ||
Even in very low doses this combination rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious. | Even in very low doses this combination rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious. | ||
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=== Opioids & Alcohol === | === Opioids & Alcohol === | ||
Both substances potentiate the | Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely. | ||
=== Tramadol & Alcohol === | === Tramadol & Alcohol === | ||
Heavy CNS depressants, risk of seizures. Both substances potentiate the | Heavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely. | ||
=== Benzodiazepines & Alcohol === | === Benzodiazepines & Alcohol === | ||
Ethanol ingestion may potentiate the CNS effects of many | Ethanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain. | ||
=== MAOIs & Alcohol === | === MAOIs & Alcohol === | ||
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The chemical tyramine in alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure. | The chemical tyramine in alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure. | ||
=== | === SSRIs & Alcohol === | ||
Alcohol may potentiate some of the pharmacologic effects of | Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills. | ||
=== Opioids & | === Opioids & GHB/GBL === | ||
The two substances potentiate each other strongly and unpredictably, very | The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. | ||
=== Tramadol & | === Tramadol & GHB/GBL === | ||
The sedative effects of this combination can lead to dangerous respiratory depression. | The sedative effects of this combination can lead to dangerous respiratory depression. | ||
=== Benzodiazepines & | === Benzodiazepines & GHB/GBL === | ||
The two substances potentiate each other strongly and unpredictably, very | The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. | ||
=== Tramadol & Opioids === | === Tramadol & Opioids === | ||
Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present | Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present. | ||
=== Benzodiazepines & Opioids === | === Benzodiazepines & Opioids === | ||
Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very | Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely. | ||
=== | === MAOIs & Opioids === | ||
Coadministration of monoamine oxidase inhibitors (MAOIs) with certain | Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases. | ||
=== Benzodiazepines & Tramadol === | === Benzodiazepines & Tramadol === | ||
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http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full | http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full | ||
===Ketamine & Amphetamine=== | |||
http://www.ncbi.nlm.nih.gov/pubmed/23660488 | |||
===Ketamine & Alcohol=== | ===Ketamine & Alcohol=== | ||
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http://www.ncbi.nlm.nih.gov/pubmed/25060403 | http://www.ncbi.nlm.nih.gov/pubmed/25060403 | ||
===DXM | ===DXM & PCP=== | ||
http://i.imgur.com/zmqaw.jpg | http://i.imgur.com/zmqaw.jpg | ||
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http://www.ncbi.nlm.nih.gov/pubmed/21756931 | http://www.ncbi.nlm.nih.gov/pubmed/21756931 | ||
===Cocaine & SSRIs=== | ===Cocaine & SSRIs=== | ||
Revision as of 17:04, 28 October 2015
WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times!
Overview[edit | edit source]
If you want to give us some feedback/recommendation/comment on the chart, you can contact us:
Email: content@tripsit.me, or email GrimReaper directly at grimreaper@tripsit.me
Chart versions[edit | edit source]
Specific Combinations[edit | edit source]
Amphetamine & Mescaline[edit | edit source]
The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops.
Cocaine & Mescaline[edit | edit source]
The focus and anxiety caused by stimulants is magnified by psychedelics and results in an increased risk of thought loops.
Caffeine & Mescaline[edit | edit source]
High doses of caffeine are uncomfortable and this will be magnified by psychedelics.
5-MeO-xxT & Mescaline[edit | edit source]
The 5-MeO class of tryptamines can be unpredictable in their interactions.
Tramadol & Mescaline[edit | edit source]
This combination can cause seizures due to the lowering of the threshold by tramadol and the potential of mescaline to cause seziures.
5-MeO-xxT & DOx[edit | edit source]
The 5-MeO class of tryptamines can be unpredictable in their interactions, particularly increasing the risk of unpleasant physical side effects.
Ketamine & DOx[edit | edit source]
Ketamine and psychedelics tend to potentiate each other - go slowly.
MXE & DOx[edit | edit source]
As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense.
DXM & DOx[edit | edit source]
The DOx class as psychedelic stimulants have the potential to mask the effects of DXM and could lead to redosing to an unsafe level. DXM can also potentiate DOx resulting in an unpleasantly intense experience.
PCP & DOx[edit | edit source]
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Amphetamine & DOx[edit | edit source]
The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of amphetamine can easily lead to thought loops. Coming down from amphetamines while the DOx is still active can be quite anxiogenic.
MDMA & DOx[edit | edit source]
The combined stimulating effects of the two can be uncomfortable. Coming down on the MDMA while the DOx is still active can be quite anxiogenic.
Cocaine & DOx[edit | edit source]
The combined stimulating effects of the two can lead to an uncomfortable body-load, while the focusing effects of cocaine can easily lead to thought loops. Coming down from cocaine while the DOx is still active can be quite anxiogenic.
Caffeine & DOx[edit | edit source]
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.
Alcohol & DOx[edit | edit source]
Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk.
Opioids & DOx[edit | edit source]
No unexpected interactions.
Tramadol & DOx[edit | edit source]
Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.
5-MeO-xxT & NBOMes[edit | edit source]
The 5-MeO class of tryptamines can be unpredictable in their interactions and the NBOMes are known to be unpredictable even alone. This combination is best avoided.
Amphetamine & NBOMes[edit | edit source]
Amphetamines and NBOMes both provide considerable stimulation. When combined they can result in tachycardia, hypertension, vasoconstriction and in extreme cases heart failure. The anxiogenic and focusing effects of stimulants are also not good in combination with psychedelics as they can lead to unpleasant thought loops. NBOMes are known to cause seizures and stimulants can increase this risk.
Cocaine & NBOMes[edit | edit source]
Cocaine and NBOMes both provide considerable stimulation. When combined they can result in severe vasoconstriction, tachycardia, hypertension, and in extreme cases heart failure.
Caffeine & NBOMes[edit | edit source]
Caffiene can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle while tripping.
Tramadol & NBOMes[edit | edit source]
Tramadol is well known to lower seizure threshold and NBOMes have also shown a tendency to cause severe seizures.
5-MeO-xxT & 2c-x[edit | edit source]
The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics.
Amphetamine & 2c-x[edit | edit source]
The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally uneccessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
Cocaine & 2c-x[edit | edit source]
The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
Caffeine & 2c-x[edit | edit source]
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Tramadol & 2c-x[edit | edit source]
Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.
Caffeine & 2C-T-x[edit | edit source]
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Alcohol & 2C-T-x[edit | edit source]
Both these classes of compound can interact unpredictably. Caution should be exercised.
Opioids & 2C-T-x[edit | edit source]
No expected interactions, some Opioids have Serotonin action, and could lead to Serotonin Syndrome or a seizure. These are pretty much only to Pentazocine, Methadone, Tramadol, Tapenatdol.
Caffeine & αMT[edit | edit source]
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Alcohol & αMT[edit | edit source]
αMT has a broad mechanism of action in the brain and so does alcohol so the combination can be unpredictable.
Opioids & αMT[edit | edit source]
No unexpected interactions
Amphetamine & 5-MeO-xxT[edit | edit source]
The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
MDMA & 5-MeO-xxT[edit | edit source]
Some of the 5-MeO tryptamines are a bit unpredictable and should be mixed with MDMA with care.
Cocaine & 5-MeO-xxT[edit | edit source]
The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics.
Amphetamine & Ketamine[edit | edit source]
Amphetamine worsens Ketamines ataxia.
Caffeine & Ketamine[edit | edit source]
No unexpected interactions.
Alcohol & Ketamine[edit | edit source]
Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
GHB/GBL & Ketamine[edit | edit source]
Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Opioids & Ketamine[edit | edit source]
Both substances bring a risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Tramadol & Ketamine[edit | edit source]
No unexpected interactions.
Benzodiazepines & Ketamine[edit | edit source]
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
Amphetamine & MXE[edit | edit source]
Risk of tachycardia, hypertension, and manic states.
MDMA & MXE[edit | edit source]
There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.
Cocaine & MXE[edit | edit source]
Stimulants taken with MXE can lead to hypermanic states much more easily, especially if sleep is avoided.
Caffeine & MXE[edit | edit source]
No likely interactions.
Alcohol & MXE[edit | edit source]
There is a high risk of memory loss, vomiting and severe ataxia from this combination.
GHB/GBL & MXE[edit | edit source]
Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
Opioids & MXE[edit | edit source]
This combination can potentiate the effects of the opioid.
Benzodiazepines & MXE[edit | edit source]
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess.
SSRIs & MXE[edit | edit source]
Depending on the SSRI this combination can be unpredictable.
Amphetamine & DXM[edit | edit source]
Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
MAOIs & DXM[edit | edit source]
High risk of serotonin syndrome.
Cocaine & DXM[edit | edit source]
Both substances raise heart rate, in extreme cases, panic attacks caused by these drugs have led to more serious heart issues.
SSRIs & DXM[edit | edit source]
High risk of serotonin syndrome.
Caffeine & DXM[edit | edit source]
High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.
Alcohol & DXM[edit | edit source]
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Additionally CNS depression can lead to difficulty breathing. Avoid on anything higher than 1st plateau.
GHB/GBL & DXM[edit | edit source]
Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the patient falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. This combination is hard to predict.
Opioids & DXM[edit | edit source]
CNS depression, difficult breathing, heart issues, hepatoxic, just very unsafe combination all around. Additionally, there is a reverse cross tolerance between opiates/dxm. I.E. if one takes dxm, their tolerance of opiates goes down slightly, thus causing additional synergistic effects.
Benzodiazepines & DXM[edit | edit source]
Small doses of benzos can end a bad trip, but both substances potentiate the ataxia and sedation caused by the other and this can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
Amphetamine & PCP[edit | edit source]
This combination can easily lead to hypermanic states.
MDMA & PCP[edit | edit source]
This combination can easily lead to hypermanic states.
Cocaine & PCP[edit | edit source]
This combination can easily lead to hypermanic states.
Caffeine & PCP[edit | edit source]
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Alcohol & PCP[edit | edit source]
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
GHB/GBL & PCP[edit | edit source]
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Opioids & PCP[edit | edit source]
PCP can reduce opioid tolerance, increasing the risk of overdose.
Benzodiazepines & PCP[edit | edit source]
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Memory blackouts are likely.
SSRIs & PCP[edit | edit source]
Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.
Alcohol & N2O[edit | edit source]
This combination can lead to vomiting.
MDMA & Amphetamine[edit | edit source]
Amphetamines increase the neurotoxic effects of MDMA.
Cocaine & Amphetamine[edit | edit source]
This combination of stimulants will increase strain on the heart. It is not generally worth it as cocaine has a mild blocking effect on dopamine releasers like amphetamine.
Caffeine & Amphetamine[edit | edit source]
This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.
Alcohol & Amphetamine[edit | edit source]
Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel the alcohol and the stimulant less. Extended release formulations may severely impede sleep, further worsening the hangover.
GHB/GBL & Amphetamine[edit | edit source]
Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Opioids & Amphetamine[edit | edit source]
Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Tramadol & Amphetamine[edit | edit source]
Tramadol and stimulants both increase the risk of seizures.
Cocaine & MDMA[edit | edit source]
Cocaine blocks some of the desirable effects of MDMA while increasing the risk of heart attack.
Caffeine & MDMA[edit | edit source]
Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA.
Alcohol & MDMA[edit | edit source]
Both MDMA and alcohol cause severe dehydration. Approach this combination with caution, moderation and sufficient hydration.
Tramadol & MDMA[edit | edit source]
Tramadol and stimulants both increase the risk of seizures.
Caffeine & Cocaine[edit | edit source]
Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.
Alcohol & Cocaine[edit | edit source]
Drinking on stimulants is risky because the sedative effects of the alcohol are reduced, and these are what the body uses to gauge drunkenness. This typically leads to excessive drinking with greatly reduced inhibitions, high risk of liver damage and increased dehydration. They will also allow you to drink past a point where you might normally pass out, increasing the risk. If you do decide to do this then you should set a limit of how much you will drink each hour and stick to it, bearing in mind that you will feel he alcohol less. Cocaine is potentiated somewhat by alcohol because of the formation of cocaethylene.
GHB/GBL & Cocaine[edit | edit source]
Stimulants increase respiration rate allowing a higher dose of sedatives. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest. Likewise the G can wear off and leave a dangerous concentration of cocaine behind.
Opioids & Cocaine[edit | edit source]
Stimulants increase respiration rate allowing a higher dose of opiates. If the stimulant wears off first then the opiate may overcome the patient and cause respiratory arrest.
Tramadol & Cocaine[edit | edit source]
Tramadol and stimulants both increase the risk of seizures.
SSRIs & Cocaine[edit | edit source]
Risk of serotonin syndrome, Likely to make the SSRI's innefective with regular cocaine use. The SSRIs may also make the cocaine less effective. Mental stability and cocaine don't go together.
GHB/GBL & Alcohol[edit | edit source]
Even in very low doses this combination rapidly leads to memory loss, severe ataxia and unconsciousness. There is a high risk of vomit aspiration while unconscious.
Opioids & Alcohol[edit | edit source]
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.
Tramadol & Alcohol[edit | edit source]
Heavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.
Benzodiazepines & Alcohol[edit | edit source]
Ethanol ingestion may potentiate the CNS effects of many benzodiazepines. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.
MAOIs & Alcohol[edit | edit source]
The chemical tyramine in alcoholic beverages can have dangerous reactions with MAOIs, causing an increase in blood pressure.
SSRIs & Alcohol[edit | edit source]
Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
Opioids & GHB/GBL[edit | edit source]
The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
Tramadol & GHB/GBL[edit | edit source]
The sedative effects of this combination can lead to dangerous respiratory depression.
Benzodiazepines & GHB/GBL[edit | edit source]
The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position.
Tramadol & Opioids[edit | edit source]
Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present.
Benzodiazepines & Opioids[edit | edit source]
Central nervous system and/or respiratory-depressant effects may be additively or synergistically present. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position Blackouts/memory loss likely.
MAOIs & Opioids[edit | edit source]
Coadministration of monoamine oxidase inhibitors (MAOIs) with certain opioids has been associated with rare reports of severe and fatal adverse reactions. There appear to be two types of interaction, an excitatory and a depressive one. Symptoms of the excitatory reaction may include agitation, headache, diaphoresis, hyperpyrexia, flushing, shivering, myoclonus, rigidity, tremor, diarrhea, hypertension, tachycardia, seizures, and coma. Death has occurred in some cases.
Benzodiazepines & Tramadol[edit | edit source]
Central nervous system- and/or respiratory-depressant effects may be additively or synergistically present. Vomit aspiration a risk when passed out, lay down in recovery position if ingested.
References[edit | edit source]
LSD & DMT[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/3006089 http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
LSD & GHB/GBL[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16483730
LSD & Opioids[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/547279
http://www.ncbi.nlm.nih.gov/pubmed/3006089
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
http://www.ncbi.nlm.nih.gov/pubmed/3006089
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
LSD & Tramadol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/3006089
LSD & MAOIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/8788508
http://www.ncbi.nlm.nih.gov/pubmed/108709
https://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2439&DocPartID=2199
LSD & SSRIs[edit | edit source]
http://www.nature.com/npp/journal/v14/n6/full/1380431a.html
http://www.ncbi.nlm.nih.gov/pubmed/8726753
DMT & Opioids[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/3006089
DMT & Tramadol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/3006089
MDMA & GHB/GBL[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16234132
http://www.ncbi.nlm.nih.gov/pubmed/22554869
http://www.ncbi.nlm.nih.gov/pubmed/20730418
http://www.ncbi.nlm.nih.gov/pubmed/16483730
DOx & Amphetamines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/1208759
Ketamine & Caffeine[edit | edit source]
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full
Ketamine & Amphetamine[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/23660488
Ketamine & Alcohol[edit | edit source]
http://onlinelibrary.wiley.com/doi/10.1002/jemt.22045/abstract
Ketamine & GHB/GBL[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16483730
Ketamine & Opioids[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/21224020
Tramadol & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
MXE & DXM[edit | edit source]
http://www.sciencedirect.com/science/article/pii/S0014488607002543
MXE & Amphetamines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/25060403
DXM & PCP[edit | edit source]
http://www.sciencedirect.com/science/article/pii/S0014488607002543
PCP & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224745/
Amphetamines & Benzodiazepines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/17320309
MDMA & Caffeine[edit | edit source]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492978/
http://link.springer.com/article/10.1007/s00213-010-1864-1
http://www.sciencedirect.com/science/article/pii/S0028390805003114
http://www.ncbi.nlm.nih.gov/pubmed/24211539
MDMA & Alcohol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/21040238
http://www.ncbi.nlm.nih.gov/pubmed/21756931
Cocaine & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/23761390
http://www.ncbi.nlm.nih.gov/pubmed/20195220
Caffeine & Alcohol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/20001110
Caffeine & Tramadol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/20837047
Caffeine & SSRIs[edit | edit source]
Alcohol & GHB/GBL[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/15274975
Alcohol & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/15739105
GHB/GBL & Opioids[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/7782758
GHB/GBL & Tramadol[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/7782758
GHB/GBL & Benzodiazepines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16483730
GHB/GBL & MAOIs[edit | edit source]
No study, but MAO B inhibitors should enhance the effects, no interaction with MAO A.
Opioids & Benzodiazepines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454351/
Opioids & MAOIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/17157368 (?)
http://www.ncbi.nlm.nih.gov/pubmed/2891392
http://www.if-pan.krakow.pl/pjp/pdf/2013/3_593.pdf
Opioids & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/23391344
http://www.ncbi.nlm.nih.gov/pubmed/20513454
http://www.ncbi.nlm.nih.gov/pubmed/16005413
http://www.ncbi.nlm.nih.gov/pubmed/18676387
http://www.ncbi.nlm.nih.gov/pubmed/17381671
Tramadol & Benzodiazepines[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/12842359
Tramadol & MAOIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pubmed/16051647
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
Benzodiazepines & SSRIs[edit | edit source]
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446479/
http://www.ncbi.nlm.nih.gov/pubmed/9435993
