(Substance class description)
(Specific combinations with references (work in progress))
Line 35: Line 35:
 
= Specific combinations with references (work in progress) =
 
= Specific combinations with references (work in progress) =
  
===LSD + DMT===
+
===LSD & DMT===
  
 
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
 
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
Line 41: Line 41:
 
http://www.ncbi.nlm.nih.gov/pubmed/3006089
 
http://www.ncbi.nlm.nih.gov/pubmed/3006089
  
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf?sequence=1
+
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
  
===LSD + GHB/GBL===
+
===LSD & GHB/GBL===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/16483730
 
http://www.ncbi.nlm.nih.gov/pubmed/16483730
  
===LSD + Opioids===
+
===LSD & Opioids===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/547279
 
http://www.ncbi.nlm.nih.gov/pubmed/547279
Line 55: Line 55:
 
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
 
"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."
  
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf?sequence=1
+
http://www.ncbi.nlm.nih.gov/pubmed/3006089
 +
 
 +
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf
  
===LSD + Tramadol===
+
===LSD & Tramadol===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/3006089
 
http://www.ncbi.nlm.nih.gov/pubmed/3006089
  
===LSD + MAOIs===
+
===LSD & MAOIs===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/8788508
 
http://www.ncbi.nlm.nih.gov/pubmed/8788508
Line 69: Line 71:
 
https://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2439&DocPartID=2199
 
https://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2439&DocPartID=2199
  
===LSD + SSRIs===
+
===LSD & SSRIs===
  
 
http://www.nature.com/npp/journal/v14/n6/full/1380431a.html
 
http://www.nature.com/npp/journal/v14/n6/full/1380431a.html
Line 75: Line 77:
 
http://www.ncbi.nlm.nih.gov/pubmed/8726753
 
http://www.ncbi.nlm.nih.gov/pubmed/8726753
  
===DMT + Opioids===
+
===DMT & Opioids===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/3006089
 
http://www.ncbi.nlm.nih.gov/pubmed/3006089
  
===DMT + Tramadol===
+
===DMT & Tramadol===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/3006089
 
http://www.ncbi.nlm.nih.gov/pubmed/3006089
  
===DOx + Amphetamines===
+
===DOx & Amphetamines===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/1208759
 
http://www.ncbi.nlm.nih.gov/pubmed/1208759
  
===Ibogaine + PCP===
+
===Ketamine & Caffeine===
  
http://www.ncbi.nlm.nih.gov/pubmed/9477000
+
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full
  
===Ibogaine + Amphetamines===
+
===Ketamine & Alcohol===
 
+
http://www.ncbi.nlm.nih.gov/pubmed/1393568 (Increase)
+
 
+
http://www.ncbi.nlm.nih.gov/pubmed/9475618
+
 
+
===Ibogaine + Cocaine===
+
 
+
(Increase) http://www.ncbi.nlm.nih.gov/pubmed/1601069
+
 
+
http://www.ncbi.nlm.nih.gov/pubmed/11085337
+
 
+
http://www.ncbi.nlm.nih.gov/pubmed/10463325
+
 
+
===Ibogaine + Opioids===
+
 
+
(Non SNRIs) http://www.ncbi.nlm.nih.gov/pubmed/1393568
+
 
+
(Non SNRIs) http://www.ncbi.nlm.nih.gov/pubmed/1893925
+
 
+
(Non SNRIs) http://www.ncbi.nlm.nih.gov/pubmed/1868880
+
 
+
===Ketamine + Amphetamines===
+
http://www.ncbi.nlm.nih.gov/pubmed/23660488
+
 
+
===Ketamine + Caffeine===
+
 
+
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full
+
===Ketamine + Alcohol===
+
  
 
http://onlinelibrary.wiley.com/doi/10.1002/jemt.22045/abstract
 
http://onlinelibrary.wiley.com/doi/10.1002/jemt.22045/abstract
  
===Ketamine + GHB/GBL===
+
===Ketamine & GHB/GBL===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/16483730
 
http://www.ncbi.nlm.nih.gov/pubmed/16483730
  
===Ketamine + Opioids===
+
===Ketamine & Opioids===
 +
 
 
http://www.ncbi.nlm.nih.gov/pubmed/21224020
 
http://www.ncbi.nlm.nih.gov/pubmed/21224020
  
===MXE + DXM===
+
===MXE & DXM===
  
 
http://i.imgur.com/zmqaw.jpg
 
http://i.imgur.com/zmqaw.jpg
Line 136: Line 111:
 
http://www.sciencedirect.com/science/article/pii/S0014488607002543
 
http://www.sciencedirect.com/science/article/pii/S0014488607002543
  
===DXM  + PCP===
+
===MXE & Amphetamines===
 +
 
 +
http://www.ncbi.nlm.nih.gov/pubmed/25060403
 +
 
 +
===DXM  & PCP===
  
 
http://i.imgur.com/zmqaw.jpg
 
http://i.imgur.com/zmqaw.jpg
Line 142: Line 121:
 
http://www.sciencedirect.com/science/article/pii/S0014488607002543
 
http://www.sciencedirect.com/science/article/pii/S0014488607002543
  
===PCP + SSRIs===
+
===PCP & SSRIs===
  
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224745/
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224745/
  
===Amphetamines + GHB/GBL===
+
===Amphetamines & Benzodiazepines===
  
http://www.ncbi.nlm.nih.gov/pubmed/22554869
+
http://www.ncbi.nlm.nih.gov/pubmed/17320309 (says unsafe :O )
  
===Amphetamines + Benzodiazepines===
+
===MDMA & Caffeine===
 
+
http://www.ncbi.nlm.nih.gov/pubmed/17320309
+
 
+
===MDMA + Caffeine===
+
  
 
http://www.ncbi.nlm.nih.gov/pubmed/22671762
 
http://www.ncbi.nlm.nih.gov/pubmed/22671762
Line 160: Line 135:
 
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02065.x/full
 
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02065.x/full
  
http://link.springer.com/article/10.1007/s00213-010-1864-1#page-1
+
http://link.springer.com/article/10.1007/s00213-010-1864-1
  
 
http://www.sciencedirect.com/science/article/pii/S0028390805003114
 
http://www.sciencedirect.com/science/article/pii/S0028390805003114
  
===MDMA + GHB/GBL===
+
===MDMA & Alcohol===
 +
 
 +
http://www.ncbi.nlm.nih.gov/pubmed/21040238
 +
 
 +
http://www.ncbi.nlm.nih.gov/pubmed/21756931
 +
 
 +
===MDMA & GHB/GBL===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/16234132
 
http://www.ncbi.nlm.nih.gov/pubmed/16234132
Line 174: Line 155:
 
http://www.ncbi.nlm.nih.gov/pubmed/16483730
 
http://www.ncbi.nlm.nih.gov/pubmed/16483730
  
===Cocaine + SSRIs===
+
===Cocaine & SSRIs===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/23761390
 
http://www.ncbi.nlm.nih.gov/pubmed/23761390
  
 
http://www.ncbi.nlm.nih.gov/pubmed/20195220
 
http://www.ncbi.nlm.nih.gov/pubmed/20195220
===Caffeine + Alcohol===
+
 
 +
===Caffeine & Alcohol===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/20001110
 
http://www.ncbi.nlm.nih.gov/pubmed/20001110
  
===Caffeine + Tramadol===
+
===Caffeine & Tramadol===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/20837047
 
http://www.ncbi.nlm.nih.gov/pubmed/20837047
  
===Caffeine + SSRIs===
+
===Caffeine & SSRIs===
  
 
http://journals.lww.com/jpharmacogenetics/abstract/1996/06000/a_fluvoxamine_caffeine_interaction_study.3.aspx
 
http://journals.lww.com/jpharmacogenetics/abstract/1996/06000/a_fluvoxamine_caffeine_interaction_study.3.aspx
  
===Alcohol + GHB/GBL===
+
===Alcohol & GHB/GBL===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/15274975
 
http://www.ncbi.nlm.nih.gov/pubmed/15274975
  
===Alcohol + SSRIs===
+
===Alcohol & SSRIs===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/15739105
 
http://www.ncbi.nlm.nih.gov/pubmed/15739105
  
===GHB/GBL + Opioids===
+
===GHB/GBL & Opioids===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/7782758
 
http://www.ncbi.nlm.nih.gov/pubmed/7782758
  
===GHB/GBL + Tramadol===
+
===GHB/GBL & Tramadol===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/7782758
 
http://www.ncbi.nlm.nih.gov/pubmed/7782758
  
===GHB/GBL + Benzodiazepines===
+
===GHB/GBL & Benzodiazepines===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/16483730
 
http://www.ncbi.nlm.nih.gov/pubmed/16483730
  
===GHB/GBL + MAOIs===
+
===GHB/GBL & MAOIs===
  
 
No study, but MAO B inhibitors should enhance the effects, no interaction with MAO A.
 
No study, but MAO B inhibitors should enhance the effects, no interaction with MAO A.
===Opioids + Benzodiazepines===
+
 
 +
===Opioids & Benzodiazepines===
  
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454351/
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454351/
  
===Opioids + MAOIs===
+
===Opioids & MAOIs===
  
http://www.ncbi.nlm.nih.gov/pubmed/17157368
+
http://www.ncbi.nlm.nih.gov/pubmed/17157368 (?)
  
 
http://www.ncbi.nlm.nih.gov/pubmed/2891392
 
http://www.ncbi.nlm.nih.gov/pubmed/2891392
Line 226: Line 209:
 
http://www.if-pan.krakow.pl/pjp/pdf/2013/3_593.pdf
 
http://www.if-pan.krakow.pl/pjp/pdf/2013/3_593.pdf
  
===Opioids + SSRIs===
+
===Opioids & SSRIs===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/23391344
 
http://www.ncbi.nlm.nih.gov/pubmed/23391344
Line 238: Line 221:
 
http://www.ncbi.nlm.nih.gov/pubmed/17381671
 
http://www.ncbi.nlm.nih.gov/pubmed/17381671
  
===Tramadol + Benzodiazepines===
+
===Tramadol & Benzodiazepines===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/12842359
 
http://www.ncbi.nlm.nih.gov/pubmed/12842359
  
===Tramadol + MAOIs===
+
===Tramadol & MAOIs===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/16051647
 
http://www.ncbi.nlm.nih.gov/pubmed/16051647
Line 248: Line 231:
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
  
===Tramadol + SSRIs===
+
===Tramadol & SSRIs===
  
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/
Line 254: Line 237:
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/
  
===Benzodiazepines + SSRIs===
+
===Benzodiazepines & SSRIs===
  
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446479/
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446479/
Line 260: Line 243:
 
http://www.ncbi.nlm.nih.gov/pubmed/9435993
 
http://www.ncbi.nlm.nih.gov/pubmed/9435993
  
===MAOIs + SSRIs===
+
===MAOIs & SSRIs===
  
 
http://www.ncbi.nlm.nih.gov/pubmed/24577320
 
http://www.ncbi.nlm.nih.gov/pubmed/24577320

Revision as of 13:40, 20 September 2014

WARNING! For educational purposes: We do not endorse any of these combinations. This page will always be 'work in progress'. It is extremely important to be safe at all times!


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General information

Substance class description

Psychedelics

  • 2C-T-x is a moderate MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-A inhibitor, can cause SerotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. Syndrome when combined with monoamine releasers, SSRIs or other MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). inhibitors.
  • αMT is a reversible MAOIMonoamine oxidase inhibitor are drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate. in higher doses (the danger rises exponentially as αMT doses approach 150 mg due to increased monoamine release and increased MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). inhibition), can cause SerotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. Syndrome when combined with monoamine releasers, SSRIs or other MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). inhibitors.

Specific combinations with references (work in progress)

LSD & DMT

"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."

http://www.ncbi.nlm.nih.gov/pubmed/3006089

http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf

LSD & GHB/GBL

http://www.ncbi.nlm.nih.gov/pubmed/16483730

LSD & Opioids

http://www.ncbi.nlm.nih.gov/pubmed/547279

http://www.ncbi.nlm.nih.gov/pubmed/3006089

"Low doses antagonized the effects of both hallucinogens, whereas larger doses enhanced their effects."

http://www.ncbi.nlm.nih.gov/pubmed/3006089

http://deepblue.lib.umich.edu/bitstream/handle/2027.42/26285/0000370.pdf

LSD & Tramadol

http://www.ncbi.nlm.nih.gov/pubmed/3006089

LSD & MAOIs

http://www.ncbi.nlm.nih.gov/pubmed/8788508

http://www.ncbi.nlm.nih.gov/pubmed/108709

https://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&ID=2439&DocPartID=2199

LSD & SSRIs

http://www.nature.com/npp/journal/v14/n6/full/1380431a.html

http://www.ncbi.nlm.nih.gov/pubmed/8726753

DMT & Opioids

http://www.ncbi.nlm.nih.gov/pubmed/3006089

DMT & Tramadol

http://www.ncbi.nlm.nih.gov/pubmed/3006089

DOx & Amphetamines

http://www.ncbi.nlm.nih.gov/pubmed/1208759

Ketamine & Caffeine

http://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2009.00382.x/full

Ketamine & Alcohol

http://onlinelibrary.wiley.com/doi/10.1002/jemt.22045/abstract

Ketamine & GHB/GBL

http://www.ncbi.nlm.nih.gov/pubmed/16483730

Ketamine & Opioids

http://www.ncbi.nlm.nih.gov/pubmed/21224020

MXEMethoxetamine & DXM

http://i.imgur.com/zmqaw.jpg

http://www.sciencedirect.com/science/article/pii/S0014488607002543

MXEMethoxetamine & Amphetamines

http://www.ncbi.nlm.nih.gov/pubmed/25060403

DXM & PCP

http://i.imgur.com/zmqaw.jpg

http://www.sciencedirect.com/science/article/pii/S0014488607002543

PCP & SSRIs

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224745/

Amphetamines & Benzodiazepines

http://www.ncbi.nlm.nih.gov/pubmed/17320309 (says unsafe :O )

MDMA & Caffeine

http://www.ncbi.nlm.nih.gov/pubmed/22671762

http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02065.x/full

http://link.springer.com/article/10.1007/s00213-010-1864-1

http://www.sciencedirect.com/science/article/pii/S0028390805003114

MDMA & Alcohol

http://www.ncbi.nlm.nih.gov/pubmed/21040238

http://www.ncbi.nlm.nih.gov/pubmed/21756931

MDMA & GHB/GBL

http://www.ncbi.nlm.nih.gov/pubmed/16234132

http://www.ncbi.nlm.nih.gov/pubmed/22554869

http://www.ncbi.nlm.nih.gov/pubmed/20730418

http://www.ncbi.nlm.nih.gov/pubmed/16483730

Cocaine & SSRIs

http://www.ncbi.nlm.nih.gov/pubmed/23761390

http://www.ncbi.nlm.nih.gov/pubmed/20195220

Caffeine & Alcohol

http://www.ncbi.nlm.nih.gov/pubmed/20001110

Caffeine & Tramadol

http://www.ncbi.nlm.nih.gov/pubmed/20837047

Caffeine & SSRIs

http://journals.lww.com/jpharmacogenetics/abstract/1996/06000/a_fluvoxamine_caffeine_interaction_study.3.aspx

Alcohol & GHB/GBL

http://www.ncbi.nlm.nih.gov/pubmed/15274975

Alcohol & SSRIs

http://www.ncbi.nlm.nih.gov/pubmed/15739105

GHB/GBL & Opioids

http://www.ncbi.nlm.nih.gov/pubmed/7782758

GHB/GBL & Tramadol

http://www.ncbi.nlm.nih.gov/pubmed/7782758

GHB/GBL & Benzodiazepines

http://www.ncbi.nlm.nih.gov/pubmed/16483730

GHB/GBL & MAOIs

No study, but MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). B inhibitors should enhance the effects, no interaction with MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). A.

Opioids & Benzodiazepines

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454351/

Opioids & MAOIs

http://www.ncbi.nlm.nih.gov/pubmed/17157368 (?)

http://www.ncbi.nlm.nih.gov/pubmed/2891392

http://www.if-pan.krakow.pl/pjp/pdf/2013/3_593.pdf

Opioids & SSRIs

http://www.ncbi.nlm.nih.gov/pubmed/23391344

http://www.ncbi.nlm.nih.gov/pubmed/20513454

http://www.ncbi.nlm.nih.gov/pubmed/16005413

http://www.ncbi.nlm.nih.gov/pubmed/18676387

http://www.ncbi.nlm.nih.gov/pubmed/17381671

Tramadol & Benzodiazepines

http://www.ncbi.nlm.nih.gov/pubmed/12842359

Tramadol & MAOIs

http://www.ncbi.nlm.nih.gov/pubmed/16051647

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/

Tramadol & SSRIs

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714818/

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750095/

Benzodiazepines & SSRIs

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2446479/

http://www.ncbi.nlm.nih.gov/pubmed/9435993

MAOIs & SSRIs

http://www.ncbi.nlm.nih.gov/pubmed/24577320

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