Diphenidine (1-(1,2-diphenylethyl)piperidine) is a dissociative anesthetic drug.
The first synthesis of diphenidine was published in 1924 by Christiaen who used a modified Brulyants reaction, similar to the reaction later used by Maddox in the first PCP synthesis.
While diphenidine was never used or investigated medically, several related compounds have been and include the withdrawn analgesic lefetamine and investigational compounds such as AstraZenica’s NMDAN-methyl-D-aspartate receptor. NMDA antagonists are often dissociatives. antagonistA substance that interferes with or inhibits the physiological action of another. antidepressant Lanicemine, and neurodegenerative disease and anti-epileptic agent Remacemide.
Shortly after the UK arylcyclohexylamineA class of dissociatives, which includes PCP, Ketamine, Methoxetamine and others. An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary, secondary amines such as methylamino or ethylamino, or tertiary cycloalkylamines such as piperidino and pyrrolidino, are the most commonly encountered N-substituents. ban in early 2013, diphenidine and its 2-MeO derivative methoxphenidine emerged on the RC market.
Diphenidine can also be insufflated, vaporized and injected. Start with low doses and work your way up.
| Threshold | 50mg |
| Light | 70-85mg |
| Common | 85-110mg |
| Heavy | 110-150mg |
| Onset | 15-30 minutes |
| Total | 2-5 hours |
| After-effects | 4-24 hours |
See Dissociative Harm Reduction for general information.
It is currently unknown whether diphenidine is a reuptake inhibitor of serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. (SRISerotonin Reuptake Inhibitor), if that is the case do NOT ever combine it with other SRIs (such as MXEMethoxetamine) or SSRIs.
Check out our Drug Combinations page and chart for interactions and combinations of common drugs.
Diphenidine is a NMDAN-methyl-D-aspartate receptor. NMDA antagonists are often dissociatives. antagonistA substance that interferes with or inhibits the physiological action of another. and possibly a reuptake inhibitor of serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. or dopamineA neurotransmitter associated with movement, attention, learning, and the brain’s pleasure and reward system..
Diphenidine is, as of July 2014, not a controlled substance in any country.