(Injected)
m
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=== Neutral ===
 
=== Neutral ===
-Time dilation
+
*Time dilation
 
+
*Intense hallucinations
-Intense hallucinations
+
*Dissociation
 
+
*Loss of comprehension of basic concepts such as ego, language or one's own body.
-Dissociation
+
*Out-of-body experiences
 
+
*Unconventional thought patterns
-Loss of comprehension of basic concepts such as ego, language or one's own body.
+
 
+
-Out-of-body experiences
+
 
+
-Unconventional thought patterns
+
  
 
=== Negative ===
 
=== Negative ===
-Panic attack/Bad trip
+
*Panic attack/Bad trip
 
+
*(oral only) Nausea/Vomitting
-(oral only) Nausea/Vomitting
+
  
 
=== After effects ===
 
=== After effects ===
-A lasting perspective shift is likely to occur.
+
*A lasting perspective shift is likely to occur.
 
+
*Depersonalization/Derealization can occur after an experience and may last up to several months.
-Depersonalization/Derealization can occur after an experience and may last up to several months.
+
*Some people experience long-term anxiety after an experience while others report a decrease in overall anxiety.
 
+
-Some people experience long-term anxiety after an experience while others report a decrease in overall anxiety.
+
  
 
== Harm Reduction ==
 
== Harm Reduction ==
  
-Operating machinery is definitely out of the question while under the influence.
+
*Operating machinery is definitely out of the question while under the influence.
 
+
*Be careful for drugs or foods interacting dangerously with any MAO-inhibitors.
-Be careful for drugs or foods interacting dangerously with any MAO-inhibitors.
+
*Only trip in a comfortable and positive environment.
 
+
-Only trip in a comfortable and positive environment.
+
  
 
== Chemistry and Pharmacology ==  
 
== Chemistry and Pharmacology ==  

Revision as of 18:11, 11 December 2013


General Information

N,N-Dimethyltryptamine or DMT for short is an short acting psychedelic entheogen which allows a person's consciousness to voyage into the most incredible dimensions, visions, thoughts and experiences imaginable.

It is most commonly classified as a psychedelic but also possesses some properties inherent to dissociatives.

It is one of the most powerful yet mysterious psychedelics in existence, but in the opinion of many users, to classify DMT as merely a drug would be doing it a great injustice as DMT seems to some as a transdimensional key into places and vistas so profound and awe inspiring that it raises many new questions regarding the nature of reality and our place within it.

Nevertheless, it is important to realize that the experience may be very difficult for some to integrate, and great care and respect is necessary to use it.

DMT exists naturally in every human being and also throughout the plant and animal kingdoms. It occurs naturally in many mammals, marine animals, trees, grasses, flowers and shoots.

DMT is closely related to serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being., the naturally occurring neurotransmitter that psychedelics affect so widely. The pharmacology of DMT is similar to that of other well-known psychedelics. It affects receptor sites for serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. in much the same way that LSD, psilocybin, and mescaline do. These serotoninA monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being. receptors are widespread throughout the body and can be found in blood vessels, tissues, muscle, glands, and skin.

There are a number of ways to acquire this entheogen. The first and most difficult way is to have some substantial chemistry knowledge and experience and actually synthesize pure DMT in a laboratory. This a rather tricky and time consuming process and requires access to some rather obscure and hard to acquire chemicals.

The most common and easiest method to acquire DMT is to extract it from the various plant species that contain the compound.

Dosage

Oral

DMT is rapidly metabolized by MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). and should therefore be combined with a MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-inhibitor such as Harmine when taken orallyRoute of administration in which the subject swallows a substance.. Otherwise, the effects will be underwhelming or barely noticeable.

Time until onset: between 10 and 60 minutes, depending on prior food intake.

Duration: 3-8 hours until peak effects subside, several more until baseline is restored.

Dosages for DMT, considering MAOs are fully inhibited, vary wildly depending on person, probably due to metabolism in great part. They can go from 30 to 150mg! If its your first time, start on the lower end!

Another factor is whether one is ingesting a whole plant brew or purified extracts. Often in ayahuasca analysis the amount of DMT found is very small (20-30mg), but also often there is redosing in ayahuasca sessions, but also its possible trace amounts of beta-carbolines and other alkaloids can improve MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). inhibition, or that other inactive plant substances can help protect DMT from fast breakdown by any potential MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin). activity.

There are a few different ways to ingest it orallyRoute of administration in which the subject swallows a substance.:

- Dissolved in acidic juice - Rolled inside a bit of smoking paper and swallowed like a pill - Put into 00 Capsules

Suggested doses:

Low dose: 30-50 mg of DMT and 50-75 mg Harmala alkaloids

Medium (typical) dose: 50-75 mg DMT and 75-100 mg Harmala alkaloids

High dose: 100+ mg of DMT, 100-150+ mg of Harmala alkaloids

Smoked-Vaporized

Time until onset: a few seconds to a couple minutes.

Note: dosage given assumes 100% effective vaporization method

Low dose: 10-15 mg

Medium (typical) dose: 15-25 mg

High dose: 25-40+ mg

Extracted DMT freebase can be vaporized for very potent effects that last around 10-15 minutes. DMT is ideally vaporized, as opposed to smoked. Vaporization is achieved by a controlled temperature that does not burn/combust DMT material (and potential impurities), but instead just makes DMT evaporate and be inhaled.

Vaporization is much smoother than smoking. Smoking leads to break down of DMT (and impurity) molecules into potential toxic nitrogen oxides, so not only it is harsher but also there is a significant loss of actives.

Vaporizing can be achieved with improvised vaporizers such as "The Inspirator mk II","The Machine" (both DIY) or commercially sold vaporizing pipes such as the Vapor Genie.

Insufflated

Duration: 45-60 minutes

Onset: 1-5 minutes

Note: Insufflated doses vary wildly, start low. Dosages given are for freebase DMT, dosage for salt form may be a little bit higher.

Low dose: 10-25 mg

Medium (typical) dose: 25-50 mg

High dose: 50-125 mg

Insufflation of DMT is a less popular method of administration because it can cause extreme physical discomfort. DMT can be snorted in both freebase and salt forms. The most common salt utilized for insufflation is DMT Fumarate. Note that highly basic substances can damage the nasal passageway so the potential user is advised to proceed with caution.

Injected

Duration: 30-45 minutes

Onset: Under 1 minute

Low dose: 10-15 mg

Medium (typical) dose: 15-25 mg

High dose: 25-40+ mg

Intravenous DMT comes on extremely fast and is the most efficient method of use. The effects are extremely similar to vaporized DMT, though IV administration is much more dangerous. It is advised that potential users avoid intravenous administration of DMT and stick to vaporization.

Effects

Positive

-Euphoria

-Feeling of awe

-Realizations about one's life

Neutral

  • Time dilation
  • Intense hallucinations
  • Dissociation
  • Loss of comprehension of basic concepts such as ego, language or one's own body.
  • Out-of-body experiences
  • Unconventional thought patterns

Negative

  • Panic attack/Bad trip
  • (oral only) Nausea/Vomitting

After effects

  • A lasting perspective shift is likely to occur.
  • Depersonalization/Derealization can occur after an experience and may last up to several months.
  • Some people experience long-term anxiety after an experience while others report a decrease in overall anxiety.

Harm Reduction

  • Operating machinery is definitely out of the question while under the influence.
  • Be careful for drugs or foods interacting dangerously with any MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-inhibitors.
  • Only trip in a comfortable and positive environment.

Chemistry and Pharmacology

Production

DMT occurs naturally in several plants and may therefore be extracted from them with little chemistry knowledge, requiring no actual synthesis.

Plants containing DMT include Mimosa hostilis/tenuflora, Psychotria viridis, Codariocalyx motorius, Diplopterys cabrerana, Acacia species, and Phalaris species.

Images

Legal

Europe

DMT is a class A substance in most European countries.

America

DMT is a schedule I substance in the United States.

Asia

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