Clonazolam (also known as Clonitrazolam) is a novel psychoactive class::depressant substance of the chemical class::benzodiazepine chemical class which produces anxiolytic, sedative, muscle relaxant, and amnesic effects when administered. This compound is a novel research chemical derivative of the FDA-approved drugs clonazepam (Klonopin, Rivitrol) and alprazolam (Xanax). Clonazolam is reported to be roughly 2.5x as potent as alprazolam.


The synthesis of clonazolam was first reported in 1971. It was described as the most active compound in the series tested.[1][2]

Very little is known about this substance, but it has recently become easily accessible through online research chemical vendors where it is being sold as a designer drug.[3][4]


Ritual use, different types of administration and how to do it, etc.


General note/warning about dosage

Threshold 50-75ug
Light 75-200ug
Common 200-400ug
Strong 500-1000ug


Onset 10-30 minutes
Total 6-10 hours
After-effects 1-12 hours (dose-dependent)



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Harm Reduction

Clonazolam is reputed to be highly potent, and concerns have been raised that it and flubromazolam may pose comparatively higher risks than other designer benzodiazepines due to their ability to produce strong sedation and amnesia at oral doses as low as 0.5 mg, or 500 micrograms (ug).[5] It is reported to have a medium-length onset of action (20 - 60 minutes).

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Due to its extremely high potency, it is often found on blotter paper or in volumetrically dosed solutions. Ingestion of raw clonazolam powder is unsafe due to its microgram-range potency and the ease in which it can lead to multi-day blackouts.


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Check out our Drug Combinations page and chart for interactions and combinations of common drugs.

Chemistry and Pharmacology

Clonazolam is a drug of the benzodiazepine class. Benzodiazepine drugs contain a benzene ring fused to a diazepine ring, which is a seven membered ring with the two nitrogen constituents located at R1 and R4. The benzyl ring of clonazolam is substituted at R8 with a nitro group, NO2-. Further, the diazepine ring is bonded at R6 to a 2-chlorinated phenyl ring.

Clonazolam also contains a 1-methylated triazole ring fused to and incorporating R1 and R2 of its diazepine ring. Clonazolam belongs to a class of benzodiazepines containing this fused triazole ring, called triazolobenzodiazepines, distinguished by the suffix "-zolam." Clonazolam is also a nitrobenzodiazepine, a subclass of benzodiazepines which contain a nitro (NO2-) group. Other nitrobenzodiazepines include clonazepam and flunitrazepam.

LD50The dosage of a substance at which 50% of the exposed subjects does not survive. To estimate the LD50 for humans, tests are conducted on non-human subjects.

Legal status

  • USA: Unscheduled
  • UK: Class C


Further Reading

Off-Site Resources

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