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== Dosage ==  
 
== Dosage ==  
{| class="wikitable"
 
|+Comparison of benzodiazepines
 
! Chemical name (brand name)
 
! Half-Life [Active Metabolites]
 
! Dose Equiv. of 10mg Diazepam (Oral)
 
! Class
 
|-
 
| Alprazolam (Xanax)
 
| 6 - 12 hours
 
| 0.5 mg
 
| Anxiolytic
 
|-
 
| Bromazepam (Lexotan, Lexomil)
 
| 10 - 20 hours
 
| 5 - 6 mg
 
| Anxiolytic
 
|-
 
| Chlordazepoxide (Librium)
 
| 5 - 30 hours [36 - 200 hours]
 
| 25 mg
 
| Anxiolytic
 
|-
 
| Clobazam (Frisium)
 
| 12 - 60 hours
 
| 20 mg
 
| Anxiolytic
 
|-
 
| Clonazepam (Klonopin)
 
| 18 - 50 hours
 
| 0.5 mg
 
| Anxiolytic
 
|-
 
| Clorazepate (Tranxene)
 
| [36 - 200 hours]
 
| 15 mg
 
| Anxiolytic
 
|-
 
| Diazepam (Valium)
 
| 20 - 100 hours [36 - 200 hours]
 
| 10 mg
 
| Anxiolytic
 
|-
 
| Estazolam (ProSom, Nuctalon)
 
| 10 - 24 hours
 
| 1 - 2 mg
 
| Hypnotic
 
|-
 
| Flunitrazepam (Rohypnol)
 
| 18 - 26 hours [36 - 200 hours]
 
| 1 mg
 
| Hypnotic
 
|-
 
| Flurazepam (Dalmane)
 
| [40 - 250 hours]
 
| 15 - 30 mg
 
| Hypnotic
 
|-
 
| Halazepam (Paxipam)
 
| [30 - 100 hours]
 
| 20 mg
 
| Anxiolytic
 
|-
 
| Ketazolam (Paxipam)
 
| 30 - 100 hours [36 - 200 hours]
 
| 15 - 30 mg
 
| Anxiolytic
 
|-
 
| Loprazolam (Dormonoct)
 
| 6 - 12 hours
 
| 1 - 2 mg
 
| Hypnotic
 
|-
 
| Lorazepam (Ativan)
 
| 10 - 20 hours
 
| 1 mg
 
| Anxiolytic
 
|-
 
| Lormetazepam (Noctamid)
 
| 10 - 12 hours
 
| 1 - 2 mg
 
| Hypnotic
 
|-
 
| Medazepam (Nobrium)
 
| 36 - 200 hours
 
| 10 mg
 
| Anxiolytic
 
|-
 
| Nitrazepam (Mogadon)
 
| 15 - 38 hours
 
| 10 mg
 
| Hypnotic
 
|-
 
| Nordazepam (Nordaz)
 
| 36 - 200 hours
 
| 10 mg
 
| Anxiolytic
 
|-
 
| Oxazepam (Serax)
 
| 4 - 15 hours
 
| 20 mg
 
| Anxiolytic
 
|-
 
| Prazepam (Centrax)
 
| [36 - 200 hours]
 
| 10 - 20 mg
 
| Anxiolytic
 
|-
 
| Quazepam (Doral)
 
| 25 - 100 hours
 
| 20 mg
 
| Hypnotic
 
|-
 
| Temazepam (Restoril)
 
| 8 - 22 hours
 
| 20 mg
 
| Hypnotic
 
|-
 
| Triazolam (Halcion)
 
| 2 hours
 
| 0.5 mg
 
| Hypnotic
 
|}
 
 
{| class="wikitable"
 
|+Non-benzodiazepines commonly referred to as Z-drugs
 
! Chemical name (brand name)
 
! Half-Life [Active Metabolites]
 
! Dose Equiv. of 10mg Diazepam (Oral)
 
! Class
 
|-
 
| Zaleplon (Sonata)
 
| 2 hours
 
| 20 mg
 
| Hypnotic
 
|-
 
| Zolpidem (Ambien)
 
| 2 hours
 
| 20 mg
 
| Hypnotic
 
|-
 
| Zopiclone (Imovane)
 
| 5 - 6 hours
 
| 15 mg
 
| Hypnotic
 
|-
 
| Eszopiclone (Lunesta)
 
| 6 hours
 
| 3 mg
 
| Hypnotic
 
|}
 
  
 
=== Oral ===
 
=== Oral ===

Revision as of 00:27, 5 March 2013


General Information

Classification: Downer/Sedative/Anxiolytic

History

Dosage

Oral

Onset:

Alprazolam IR : 8-25 minutes

Alprazolam XR : 25-75 minutes

Diazepam : Rapid

Clonazapam: 1 hour

Peak Benefit:

Diazepam: 1.6 hours

Alprazolam IR : 90 minutes

Alprazolam XR : 25-75 minutes

Diazepam : 2-4 hours

Clonazapam: 1-4 hours

Half/Life and Duration

Triazolam: 2.5 Hours

Lorazepam:

Alprazolam IR : 11 hour half life - 5 hour duration

Alprazolam XR :11-16 hour hour half life, 11 hour duration

Diazepam : 20-100 hour half life - 6-8 hour duration

Clonazepam: 18-50 hour half life - 12+ hours

Dosages Depend on tolerance.

Potentiators:

-Grapefruit juice

Avoid:

-Excessive drinking (you will die)

Smoked

Duration: X hours

Onset: X minutes

Low dose: X mg

Medium (typical) dose: X mg

High dose: X mg

Insufflated

NOT RECOMMENDED

Duration: X hours

Onset: X minutes

Low dose: X mg

Medium (typical) dose: X mg

High dose: X mg

Injected

NOT RECOMMENDED

Duration: X hours

Onset: X minutes

Low dose: X mg

Medium (typical) dose: X mg

High dose: X mg

Effects

Positive

  • Stress Relief
  • Anxiety Relief
  • Social Anxiety
  • PTSD
  • Sedative
  • Worries drift away
  • That "sink into the couch" feeling

Neutral

Negative

  • High addiction potential
  • Killer withdrawals
  • Risk of blackout
  • Inability to drink
  • Inability to dirve
  • Loss of balance
  • Memory Loss
  • Procrastination

After effects

  • "Hangover"?
  • Afterglow
  • Long term effects
  • High addiction potential

Harm Reduction

  • Avoid driving and operating heavy machinery
  • Recommended time (pauses) between using the substance
  • Addiction potential - High
  • Risk of blackouts
  • Risk of death when mixed with alcohol
  • Mental illness?
  • Heart issues?
  • CNSCentral Nervous System depressant when mixed with other drugs

Chemistry and Pharmacology

Production

Images

Legal

Europe

America

Asia

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