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2C-E is a chemical of the 2C-X series which is characterised by its particularly intense visuals and higher potency when compared with other members of the family.
2C-E, like many of its close analogues, was first synthesized by Alexander Shulgin and published in PiHKAL. He was quite fond of it, granting it a place in his "Magical Half Dozen" alongside of DOM, 2C-B, 2C-T-2 & 7 and mescaline.
2C-E is mainly a recreational entheogen. It can be quite introspective in appropriate doses and settings. It doesn't lend itself well to intense party-like surroundings, much like LSD or similarly intense psychedelics.
Dosages from TripSit Factsheets
Note: Duration can be significantly longer with higher doses.
Anecdotal evidence has shown the oral onset of 2C-E may vary wildly for some users, taking up to three hours before first effects in some cases.
2C-E is a psychedelic phenethylaminePhenethylamine (PEA) is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. In the mammalian central nervous system, phenethylamine is believed to function as a neuromodulator or neurotransmitter. and as such has psychedelic and stimulant effects. As with all psychedelics, different users are likely to experience different sets of effects, which usually include some however very rarely would include all of the following effects.
Compared to other members of the 2C-X family, 2C-E is generally considered to have a heavier body load and to be more visual than its counterparts.
Note: The prevalence of negative effects increases with higher doses.
See Psychedelic Harm Reduction for more information.
See Stimulant Harm Reduction for more information.
See the Drug combinations chart for more information.
2,5-Dimethoxy-4-ethylphenethylamine is a colorless oil and analogue of mescaline. Similarly it is classified as a psychedelic phenethylaminePhenethylamine (PEA) is a natural monoamine alkaloid, trace amine, and psychoactive drug with stimulant effects. In the mammalian central nervous system, phenethylamine is believed to function as a neuromodulator or neurotransmitter.. It shares the substituted amphetamine core found in the structure of many entactogens. Crystalline forms are obtained as the amine salt by reacting the free base with a mineral acid, typically HCl. It is soluble in both water and ethanol. Maximum concentration in H2O is reported at ~50mg/ml and it is said to be relatively stable in solution. A drop below normal ambient temperatures can cause particles to crystalize out.
Shulgin does not report an exact boiling point for the free base, stating only that during one synthesis the fraction boiling between 90-100 °C at 0.25 mmHg pressure was collected and converted to the hydrochloride salt. Shulgin reports the melting point of the hydrochloride salt as 208.5-210.5 °C.
A full write up on Shulgin's synthesis for 2C-E can be found here.
Like most psychedelic drugs, 2C-E is a 5-HT2a AgonistA substance that initiates a physiological response when combined with a receptor.; from that, we can presume the concurrent or pre-administration of SSRIs may reduce the effects of 2C-E. 2C-E is one of the most potent of the 2C-X family, behind only 2C-P and 2C-T-4. The 2C-X family, specifically, 2C-E, 2C-I, and 2C-C all stimulated G protein binding, suggesting more of an activity similar to tryptamines such as 5-MeO-DMT and, interestingly, DPTDipropyltryptamine. G Proteins are membrane proteins that effectively mediate interaction between hormone receptors and enzymes responsible for changes of metabolism as a result of hormonal changes.
In rats, Stage I metabolism involved deamination and O-Demthylation, which are related to the Monoamine oxidase (MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).) and cytochrome P450 (CYP) enzymes. For virtually all the 2C’s, (B,I,D,E,T-2, and T-7), MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-A and MAOMonoamine Oxidase, an enzyme that catalyses the metabolism of many drugs (e.g., DMT, dopamine and serotonin).-B were reacted upon; interestingly, ½ of the molecules in Shulgin’s Magical Half Dozen (2C-E, 2C-T-2, 2C-T-7, with the addition of 2C-D) also act to a small extent on the CYP2D6 enzyme. Because of the commonality of these receptors, the 2C-X family is likely to be more reactive with other concurrently administered chemicals.
The LD50The dosage of a substance at which 50% of the exposed subjects does not survive. To estimate the LD50 for humans, tests are conducted on non-human subjects. in humans is not currently known. Use caution when exploring high doses of this compound.