Uncommon Benzodiazepines - Revision history

Sleep at 02:14, 8 November 2017

2017-11-08T02:14:59Z

← Older revision		Revision as of 21:14, 7 November 2017
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	Clotiazepam - Thienodiazepine, Stage 2 NREM sleep is significantly increased by this drug. Effective in short term management of anxiety. Used in France/Japan. 95+ BA orally. 6-18 HL.		Clotiazepam - Thienodiazepine, Stage 2 NREM sleep is significantly increased by this drug. Effective in short term management of anxiety. Used in France/Japan. 95+ BA orally. 6-18 HL.

	Cloxazolam - Metabolised into delorazepam. ~~Uh... Increased~~ heart rate ~~for some? No sense. Typical benzo other than that~~.		Cloxazolam - Metabolised into delorazepam. When tested alongside Diazepam, some reported an increase in heart rate.

	Loprazolam - Imidazole deriv. Marketed for short term treatment of insomnia.		Loprazolam - Imidazole deriv. Marketed for short term treatment of insomnia.

Sleep: ... Don't even know what to say.

2017-10-28T15:43:00Z

... Don't even know what to say.

← Older revision		Revision as of 10:43, 28 October 2017
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	Ketazolam - Similar effects to Diazepam. With less sedation.		Ketazolam - Similar effects to Diazepam. With less sedation.

	Pinazepam - Fucking odd wiki page. Something something fetus... But, has a propargyl group for whatever reason. Appears to produce anxiolytic shit in animals. Main metabolites are nor-desmethyldiazepam and oxazepam ~~(wat?)~~		Pinazepam - Fucking odd wiki page. Something something fetus... But, has a propargyl group for whatever reason. Appears to produce anxiolytic shit in animals. Main metabolites are nor-desmethyldiazepam and oxazepam.

	Quazepam - Trifluoroethyl ~~(Make it a methyl god dammit)~~ Selectively targets GABA(A) subtype A1 which is responsible for sleep. Subs completely in animals in Ambien/Lunesta ~~(PLEASE GET ME THIS)~~		Quazepam - Trifluoroethyl, Selectively targets GABA(A) subtype A1 which is responsible for sleep. Subs completely in animals in Ambien/Lunesta.

	Tetrazepam - Weak muscle relaxing anxiolytic		Tetrazepam - Weak muscle relaxing anxiolytic

	Triazolam - Short activity, heavy sedative, very euphoric. Was a common benzo in the US until it wa found that use in the elderly was known to cause deaths, now it is rarely prescribed.		Triazolam - Short activity, heavy sedative, very euphoric. Was a common benzo in the US until it was found that use in the elderly was known to cause deaths, now it is rarely prescribed.

	Zolazepam - Used with Tiletamine as a veterinary anaesthetic. Telazol is 1:1 ratio of the compounds. 4x potency of diazepam.		Zolazepam - Used with Tiletamine as a veterinary anaesthetic. Telazol is 1:1 ratio of the compounds. 4x potency of diazepam.

Sleep: Fixing my dumbass errors, again.

2017-09-05T23:49:09Z

Fixing my dumbass errors, again.

Sleep: Fixing my dumbass errors.

2017-09-05T23:45:51Z

Fixing my dumbass errors.

Sleep: I'll make it pretty.

2015-01-13T15:04:06Z

I'll make it pretty.

Show changes

Sleep at 14:50, 28 October 2013

2013-10-28T14:50:20Z

← Older revision		Revision as of 09:50, 28 October 2013
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	:Debazepide - (MK-329) Lacking affinity for GABA-A, instead acting as a Cholecystokinin antagonist selective for the CCK-A subtype Appetite stimulanting.		:Debazepide - (MK-329) Lacking affinity for GABA-A, instead acting as a Cholecystokinin antagonist selective for the CCK-A subtype Appetite stimulanting.

	:Diclazepam - RC. Meta's into 6-chloro-temazepam/delorazepam/desmethyldiazepam.Actually name: Chlorodiazepam		:Diclazepam - RC. Meta's into 6-chloro-temazepam/delorazepam/desmethyldiazepam. Actually name: Chlorodiazepam

	:Doxefazepam - Used therapeutically as a hypnotic. 2-4x more potent than Dalmane/Flurazepam.		:Doxefazepam - Used therapeutically as a hypnotic. 2-4x more potent than Dalmane/Flurazepam.

	:Ethyl Carfluzepate - Similar to Ethyl Loflazepate ~~(OBVIOUSLY)~~ Mainly Sedative/Hypnotic.		:Ethyl Carfluzepate - Similar to Ethyl Loflazepate, Mainly Sedative/Hypnotic.

	:Ethyl Dirazepate - Anxiolytic/Hypnotic. Uninteresting.		:Ethyl Dirazepate - Anxiolytic/Hypnotic. Uninteresting.
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	:Flubromazepam - (RC) 8mg = 10mg diazepam.		:Flubromazepam - (RC) 8mg = 10mg diazepam.

	:Fletazepam - More muscle relaxant (GABA-B?) Most closely related to Halazepam and Quazepam. ~~(Fluro's everywhere)~~		:Fletazepam - More muscle relaxant (GABA-B?) Most closely related to Halazepam and Quazepam.

	:Fludiazepam - Maeketed in Taiwan/Japan in .25mg tablets (Erispan) 4 times more binding affinity towards GABA then Diazepam. Interesting.		:Fludiazepam - Maeketed in Taiwan/Japan in .25mg tablets (Erispan) 4 times more binding affinity towards GABA then Diazepam. Interesting.

Sleep: 1,4-Benzodiazepines

2013-10-28T14:49:04Z

1,4-Benzodiazepines

New page

'''1,4-Benzodiazepines'''

:Camazepam - Dimethyl Carbamate (Gaba-B?) ester of Temazepam. Has little anticonvulsant/hypnotic/relaxant properties. Very low affinity for all Benzo receptors. Meta. into Temazepam. Is believed to increase attention(?) High oral BA (90%)(A.K.A Albego, Limpidon, and Paxor) Was scripted in Italy/Spain/Switzerland. 6-11 hour Half life.

:Elfazepam - Appetite stimulanting (Like antipyschs?) Sedative/Anxiolytic. Interesting and the stem of one of my names!

:Carburazepam - Could be an analogue of Temazepam/Camazepam. Will research further

:Cinolazepam - Has all the normal benzo properties. Has strong sedative properties, used primarily used as an hypnotic... Interesting. Will look further into possible analogues.

:Cyprazepam - Once again, nothing on it. Sedative-hypnotic... Will look further into possible analogues.

:Delorazepam - (Chlordesmethyldiazepam) Deriv. of Desmethyldiazepam. Marketed in Italy, available under EN and Dadumir. Active metabolite of Diclazepam and Cloxazolam. Mainly used as an anxiolytic because of long half life (80-115 hours) BA is around 77%. Peak plasma is within an hour. 1mg=10mg diazepam.

:Demoxepam - Metabolite of Chloridiazepoxide (Librium) Uninteresting. 35-40 hour half life.

:Debazepide - (MK-329) Lacking affinity for GABA-A, instead acting as a Cholecystokinin antagonist selective for the CCK-A subtype Appetite stimulanting.

:Diclazepam - RC. Meta's into 6-chloro-temazepam/delorazepam/desmethyldiazepam.Actually name: Chlorodiazepam

:Doxefazepam - Used therapeutically as a hypnotic. 2-4x more potent than Dalmane/Flurazepam.

:Ethyl Carfluzepate - Similar to Ethyl Loflazepate (OBVIOUSLY) Mainly Sedative/Hypnotic.

:Ethyl Dirazepate - Anxiolytic/Hypnotic. Uninteresting.

:Ethyl Loflazepate - Normal Benzo effects. Problems with very high doses (What doses?) Half life is 51-103 hours. Scripted in Mexico (Victan). Seems... really toxic at all doses.

:Flubromazepam - (RC) 8mg = 10mg diazepam.

:Fletazepam - More muscle relaxant (GABA-B?) Most closely related to Halazepam and Quazepam. (Fluro's everywhere)

:Fludiazepam - Maeketed in Taiwan/Japan in .25mg tablets (Erispan) 4 times more binding affinity towards GABA then Diazepam. Interesting.

← Older revision		Revision as of 18:49, 5 September 2017
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	Clonazepam - Chlorinated derivative of nitrazepam. Up to 50 hour HL		Clonazepam - Chlorinated derivative of nitrazepam. Up to 50 hour HL

	Diazepam - The gold ~~mother fucking~~ standard. Used in Alcohol withdrawals and benzodiazepine withdrawals.		Diazepam - The gold standard. Used in Alcohol withdrawals and benzodiazepine withdrawals.

	Flurazepam - Very long half life (Up to 250 hours) which makes it practically useless as a hypnotic, but... hmm. Interesting.		Flurazepam - Very long half life (Up to 250 hours) which makes it practically useless as a hypnotic, but... hmm. Interesting.
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	Lormetazepam - ^^		Lormetazepam - ^^

	Midazolam - Water ~~soluable~~, ~~shit burns snorted. wat.~~ Is now used other than Pentobarbital in Lethal Injection.		Midazolam - Water soluble, Is now used other than Pentobarbital in Lethal Injection.

	Nitrazepam - Typical benzo. Tolerance raises fast.		Nitrazepam - Typical benzo. Tolerance raises fast.
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	Oxazepam - Typical benzo. Moderate affinity for all. Slow onset.		Oxazepam - Typical benzo. Moderate affinity for all. Slow onset.

	Prazepam - Long half life (up to 224hrs) however ~~less~~ side effects than normal benzos.		Prazepam - Long half life (up to 224hrs) however fewer side effects than normal benzos.

	Temazepam - 3-OH hypnotic. Approved in the US ~~(ofc)~~ for short term treatment of insomnia. Typical benzo, but is fairly euphoric.		Temazepam - 3-OH hypnotic. Approved in the US for short term treatment of insomnia. Typical benzo, but is fairly euphoric.


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	Medazepam - Must have someone smarter than me read this as I understand none of it. But yeah... *		Medazepam - Must have someone smarter than me read this as I understand none of it. But yeah... *

	Nordazepam - Active metabolite of Diazepam/Chlordiazepoxide/Clorazepate/Prazepam/Pinazepam/Medazepam ~~God damn~~. Up to 200 hour half life.		Nordazepam - Active metabolite of Diazepam/Chlordiazepoxide/Clorazepate/Prazepam/Pinazepam/Medazepam. Up to 200 hour half life.

	Tofisopam - anxiolytic but no anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. PDE10A inhibitor, so could be useful in schizophrenia		Tofisopam - anxiolytic but no anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. PDE10A inhibitor, so could be useful in schizophrenia
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	Etizolam - Unscheduled in Western countries, so has become an RC too.		Etizolam - Unscheduled in Western countries, so has become an RC too.

	Fludiazepam - ~~strong~~ Diazepam analogue, 4x binding affinity of Diazepam.		Fludiazepam - Strong Diazepam analogue, 4x binding affinity of Diazepam.

	Flutazolam - Japanese benzo		Flutazolam - Japanese benzo
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	Menitrazepam - Similar in structure to tetrazepam and nimetazepam. 7-chloro group of tetrazepam replaced with nitro by the looks. Mainly hypnotic, but effects take longer to come up.		Menitrazepam - Similar in structure to tetrazepam and nimetazepam. 7-chloro group of tetrazepam replaced with nitro by the looks. Mainly hypnotic, but effects take longer to come up.

	QH-II-66 - Highly ~~selevctive~~ GABAa5 agonist which was created to replicate the effects of alcohol.		QH-II-66 - Highly selective GABAa5 agonist which was created to replicate the effects of alcohol.

	Quazepam - 200 hour half-life hypnotic benzo.		Quazepam - 200-hour half-life hypnotic benzo.

	Reclazepam - Similar effects to other benzo deriv's. ~~Short~~ duration of action.		Reclazepam - Similar effects to other benzo deriv's. A short duration of action.

	Ro5-2904 - High affinity for GABA(A)		Ro5-2904 - High affinity for GABA(A)
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	Bretazenil - Highly potent, partial GABAa agonist with less tolerance than normal. ~~Possible~~ base for better social drug than alcohol.		Bretazenil - Highly potent, partial GABAa agonist with less tolerance than normal. A possible base for a better social drug than alcohol.

	Climazolam - Similar in structure to triazolam and is used in veterinary medicine for ~~anesthetizing~~ animals. Interesting.		Climazolam - Similar in structure to triazolam and is used in veterinary medicine for anaesthetizing animals. Interesting.

	FG-8205 - Related to Bretazenil, slight selectivity for a1, little sedation.		FG-8205 - Related to Bretazenil, slight selectivity for a1, little sedation.
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	Ripazepam - Related to Zolazepam.		Ripazepam - Related to Zolazepam.

	Zomebazam - Anxiolytic properties, ~~strucutally~~ related to Razobazam and Zometapine.		Zomebazam - Anxiolytic properties, structurally related to Razobazam and Zometapine.


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	Avizafone - Water soluable prodrug to Diazepam, can be IM'd. Used mainly as an antidote to poisoning with ~~Organophophate~~ nerve agents.		Avizafone - Water soluable prodrug to Diazepam, can be IM'd. Used mainly as an antidote to poisoning with Organophosphate nerve agents.

← Older revision		Revision as of 18:45, 5 September 2017
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	Brotizolam - Extremely potent benzo active at 80-100ug.		Brotizolam - Extremely potent benzo active at 80-100ug.

	Camazepam - Benzo with reduced side effects such as impaired cognition. ~~Metabolises~~ into Temazepam.		Camazepam - Benzo with reduced side effects such as impaired cognition. Metabolites into Temazepam.

	Clobazepam - selective ω2 agonist on the GABAa receptor. Non-hypnotic. GABA(B)		Clobazepam - selective ω2 agonist on the GABAa receptor. Non-hypnotic. GABA(B)
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	Flumazenil - GABA(A) ANTAGONIST. I don't understand this at all. It's something.		Flumazenil - GABA(A) ANTAGONIST. I don't understand this at all. It's something.

	Flunitrazepam - ~~Strongest hypnotic benzo available, high~~ potency, causes heavy amnesia (commonly referred to as a date-rape drug). Only prescribed in the worst of cases for insomnia and is only prescribed for short term use.		Flunitrazepam - High potency, causes heavy amnesia (commonly referred to as a date-rape drug). Only prescribed in the worst of cases for insomnia and is only prescribed for short-term use.

	Ketazolam - Similar effects to Diazepam. With less sedation.		Ketazolam - Similar effects to Diazepam. With less sedation.

	Pinazepam - Fucking odd wiki page. Something something fetus... But, has a propargyl group for whatever reason. Appears to produce anxiolytic shit in animals. Main metabolites are ~~nordesmethyldiazepam~~ and oxazepam (wat?)		Pinazepam - Fucking odd wiki page. Something something fetus... But, has a propargyl group for whatever reason. Appears to produce anxiolytic shit in animals. Main metabolites are nor-desmethyldiazepam and oxazepam (wat?)

	Quazepam - Trifluoroethyl (Make it a methyl god dammit) ~~Selectivly~~ targets GABA(A) subtype A1 which is responsible for sleep. Subs completely in animals in Ambien/Lunesta (PLEASE GET ME THIS)		Quazepam - Trifluoroethyl (Make it a methyl god dammit) Selectively targets GABA(A) subtype A1 which is responsible for sleep. Subs completely in animals in Ambien/Lunesta (PLEASE GET ME THIS)

	Tetrazepam - Weak muscle relaxing anxiolytic		Tetrazepam - Weak muscle relaxing anxiolytic
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	Triazolam - Short activity, heavy sedative, very euphoric. Was a common benzo in the US until it wa found that use in the elderly was known to cause deaths, now it is rarely prescribed.		Triazolam - Short activity, heavy sedative, very euphoric. Was a common benzo in the US until it wa found that use in the elderly was known to cause deaths, now it is rarely prescribed.

	Zolazepam - Used with Tiletamine as a ~~ventinary~~ anaesthetic. Telazol is 1:1 ratio of the compounds. 4x potency of diazepam.		Zolazepam - Used with Tiletamine as a veterinary anaesthetic. Telazol is 1:1 ratio of the compounds. 4x potency of diazepam.


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	Phenazepam - Potent soviet benzo, now RC.		Phenazepam - Potent soviet benzo, now RC.

	Pyrazolam - Water ~~soluable~~ benzo, that is mostly anxiolytic.		Pyrazolam - Water soluble benzo, that is mostly anxiolytic.