PCP - Revision history

Sleep at 02:17, 9 May 2017

2017-05-09T02:17:42Z

← Older revision		Revision as of 21:17, 8 May 2017
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	If you think you are overdosing on PCP, please seek emergency medical attention immediately.		If you think you are overdosing on PCP, please seek emergency medical attention immediately.

	* At an Emergency Room. , Doctors usually provide a [https://wiki.tripsit.me/wiki/Benzodiazepines benzodiazepine] and between 1-10mg Haloperidol (anti-psychotic) to combat PCP overdoses and violent or unpredictable behavior.		* At an Emergency Room. , Doctors usually provide a [https://wiki.tripsit.me/wiki/Benzodiazepines benzodiazepine] or Phenobarbital and between 1-10mg Haloperidol (anti-psychotic) to combat PCP overdoses and violent or unpredictable behavior.

	* Do not drive or operate heavy machinery.		* Do not drive or operate heavy machinery.

Sleep: Fixed a fair amount of small grammatical/spelling errors. Also changed "Lorazepam" to "a benzodiazepine" under Harm reduction.

2017-05-09T01:54:12Z

Fixed a fair amount of small grammatical/spelling errors. Also changed "Lorazepam" to "a benzodiazepine" under Harm reduction.

← Older revision		Revision as of 20:54, 8 May 2017
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	== History ==		== History ==

	~~Phencyclidin~~ was first synthesized in 1926. In 1956 it was approved as ~~anesthetic~~ for animals (Sernylan), and in 1963 for humans (Sernyl) in Germany. However, due to hallucinations experienced by patients under ~~it's~~ influence it was already removed from the market in 1965. In 1967 PCP first appeared at music festivals in the US. Like ketamine, PCP was formerly used as a ~~preinduction anesthetic~~ and animal ~~tranquilizer~~, hence it has street eponyms such as “horse ~~tranquilizer~~", ”hog”, and “elephant”.		Phencyclidine was first synthesized in 1926. In 1956 it was approved as an anaesthetic for animals (Sernylan), and in 1963 for humans (Sernyl) in Germany. However, due to hallucinations experienced by patients under its influence, it was already removed from the market in 1965. In 1967 PCP first appeared at music festivals in the US. Like ketamine, PCP was formerly used as a pre-induction anaesthetic and animal tranquillizer, hence it has street eponyms such as “horse tranquillizer", ”hog”, and “elephant”.

	== Dosage ==		== Dosage ==
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	== Effects ==		== Effects ==

	Behavioural effects can vary by dosage. Low doses produce a numbness in the extremities and intoxication, ~~characterized~~ by staggering, unsteady gait, slurred speech, bloodshot eyes, and loss of balance. Moderate doses (5–10 mg intranasal, or 0.01–0.02 mg/kg intramuscular or intravenous) will produce analgesia and ~~anesthesia~~. High doses may lead to convulsions. Users frequently do not know how much of the drug they are taking due to its potency and tendency of the drug to be made illegally in uncontrolled conditions.		Behavioural effects can vary by dosage. Low doses produce a numbness in the extremities and intoxication, characterised by staggering, unsteady gait, slurred speech, bloodshot eyes, and loss of balance. Moderate doses (5–10 mg intranasal, or 0.01–0.02 mg/kg intramuscular or intravenous) will produce analgesia and anaesthesia. High doses may lead to convulsions. Users frequently do not know how much of the drug they are taking due to its potency and tendency of the drug to be made illegally in uncontrolled conditions.

	Psychological effects include severe changes in body image, loss of ego boundaries, paranoia and depersonalization. Hallucinations, euphoria, and suicidal impulses are also reported, as well as occasional aggressive behavior. Like many other drugs, phencyclidine has been known to alter mood states in an unpredictable fashion, causing some individuals to become detached, and others to become animated. PCP may induce feelings of strength, power, and invulnerability as well as a numbing effect on the mind.		Psychological effects include severe changes in body image, loss of ego boundaries, paranoia and depersonalization. Hallucinations, euphoria, and suicidal impulses are also reported, as well as occasional aggressive behavior. Like many other drugs, phencyclidine has been known to alter mood states in an unpredictable fashion, causing some individuals to become detached, and others to become animated. PCP may induce feelings of strength, power, and invulnerability as well as a numbing effect on the mind.

	=== Postive ===		=== Postive ===
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	* Ataxia (loss of motor coordination)		* Ataxia (loss of motor coordination)

	* Severe confusion, ~~disorganized~~ thinking		* Severe confusion, disorganised thinking

	* Psychotic episodes		* Psychotic episodes
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	If you think you are overdosing on PCP, please seek emergency medical attention immediately.		If you think you are overdosing on PCP, please seek emergency medical attention immediately.

	* At an Emergency Room, Doctors usually provide ~~1mg Lorazepam (~~benzodiazepine) and 1-10mg Haloperidol (anti-psychotic) to combat PCP overdoses and violent or unpredictable behavior.		* At an Emergency Room. , Doctors usually provide a [https://wiki.tripsit.me/wiki/Benzodiazepines benzodiazepine] and between 1-10mg Haloperidol (anti-psychotic) to combat PCP overdoses and violent or unpredictable behavior.

	* Do not drive or operate heavy machinery.		* Do not drive or operate heavy machinery.
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	* Avoid walking or moving in general if possible.		* Avoid walking or moving in general if possible.

	* Always experiment with drugs with a sober friend in a safe place. Start low, increase until desired effect		* Always experiment with drugs with a sober friend in a safe place. Start low, increase until the desired effect.

	* A full stomach may lead to nausea; consider fasting 3-4+ hours before usage.		* A full stomach may lead to nausea; consider fasting 3-4+ hours before usage.
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	* Alchohol		* Alchohol

	* ~~Benzodiazpines~~		* Benzodiazepines

	=== Interactions ===		=== Interactions ===
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	== Chemistry and Pharmacology ==		== Chemistry and Pharmacology ==

	In chemical structure, PCP is an arylcyclohexylamine derivative, and, in pharmacology, it is a member of the family of dissociative ~~anesthetics~~. PCP works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA receptor and, like most ~~antiglutamatergic~~ hallucinogens, is significantly more dangerous than other categories of hallucinogens.		In chemical structure, PCP is an arylcyclohexylamine derivative, and, in pharmacology, it is a member of the family of dissociative anaesthetics. PCP works primarily as a NMDA receptor antagonist, which blocks the activity of the NMDA receptor and, like most anti-glutamatergic hallucinogens, is significantly more dangerous than other categories of hallucinogens.

	The clinical picture may wax and wane between extreme agitation and sedation, because PCP can produce CNS stimulation and depression through its different clinical effects in the CNS. With increasing concentrations, the drug binds to NMDA receptors, acts as a monoamine reuptake inhibitor, stimulates σ-opioid receptors, as well as nicotinic, muscarinic and GABA receptors.		The clinical picture may wax and wane between extreme agitation and sedation because PCP can produce CNS stimulation and depression through its different clinical effects in the CNS. With increasing concentrations, the drug binds to NMDA receptors, acts as a monoamine reuptake inhibitor, stimulates σ-opioid receptors, as well as nicotinic, muscarinic and GABA receptors.

	There are more than 125 known derivates of PCP.		There are more than 125 known derivates of PCP.

Reality: tdose pcp

2016-05-07T16:25:59Z

tdose pcp

← Older revision		Revision as of 11:25, 7 May 2016
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	Note: 20 mg may put an individual into a comatose state, and 70 mg may induce seizures.		Note: 20 mg may put an individual into a comatose state, and 70 mg may induce seizures.

	{~~\| class="wikitable"~~		{{#tdose: pcp }}
	~~\|+ Smoked~~
	\|-
	~~\| Light \|\| 3-5mg~~
	\|-
	~~\| Common \|\| 5-10mg~~
	\|-
	~~\| Strong \|\| 10mg+~~
	\|}

	== Duration ==		== Duration ==

GrimReaper at 06:58, 11 March 2015

2015-03-11T06:58:04Z

← Older revision		Revision as of 01:58, 11 March 2015
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	[[File:Pcp.jpg\|right]]		[[File:Pcp.jpg\|right]]

	~~= General Information =~~		'''PCP''' is a powerful dissociative. The acronym PCP stems from its organic name 1-(1-phenylcyclohexyl) piperidine, which alludes to its relatively simple production from the arylcyclohexylamine piperidine. It is best known for stories of the strange and sometimes violent behavior of people under its influence. However, studies by the Drug Abuse Warning Network in the 1970s show that media reports of PCP-induced violence are greatly exaggerated and that incidents of violence are unusual and often (but not always) limited to individuals with reputations for aggression regardless of drug use. It has been implicated as a major cause of psychiatric decompensation and has a number of clinical syndromes described in the literature. In addition, PCP has been shown to cause significant medical morbidity and mortality. It is found in a variety of forms including crystals/powder, tablets, and liquid. Recently PCP seems to be available on the underground market most commonly in form of cannabis joints, regular cigarettes or cannabis leaf which are dipped in liquid PCP, and usually marketed as something else, seldom as 'PCP'.

	PCP is a powerful dissociative. The acronym PCP stems from its organic name 1-(1-phenylcyclohexyl) piperidine, which alludes to its relatively simple production from the arylcyclohexylamine piperidine. It is best known for stories of the strange and sometimes violent behavior of people under its influence. However, studies by the Drug Abuse Warning Network in the 1970s show that media reports of PCP-induced violence are greatly exaggerated and that incidents of violence are unusual and often (but not always) limited to individuals with reputations for aggression regardless of drug use. It has been implicated as a major cause of psychiatric decompensation and has a number of clinical syndromes described in the literature. In addition, PCP has been shown to cause significant medical morbidity and mortality. It is found in a variety of forms including crystals/powder, tablets, and liquid. Recently PCP seems to be available on the underground market most commonly in form of cannabis joints, regular cigarettes or cannabis leaf which are dipped in liquid PCP, and usually marketed as something else, seldom as 'PCP'.

	== History ==		== History ==
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	Phencyclidin was first synthesized in 1926. In 1956 it was approved as anesthetic for animals (Sernylan), and in 1963 for humans (Sernyl) in Germany. However, due to hallucinations experienced by patients under it's influence it was already removed from the market in 1965. In 1967 PCP first appeared at music festivals in the US. Like ketamine, PCP was formerly used as a preinduction anesthetic and animal tranquilizer, hence it has street eponyms such as “horse tranquilizer", ”hog”, and “elephant”.		Phencyclidin was first synthesized in 1926. In 1956 it was approved as anesthetic for animals (Sernylan), and in 1963 for humans (Sernyl) in Germany. However, due to hallucinations experienced by patients under it's influence it was already removed from the market in 1965. In 1967 PCP first appeared at music festivals in the US. Like ketamine, PCP was formerly used as a preinduction anesthetic and animal tranquilizer, hence it has street eponyms such as “horse tranquilizer", ”hog”, and “elephant”.

	= Dosage =		== Dosage ==

	Note: 20 mg may put an individual into a comatose state, and 70 mg may induce seizures.		Note: 20 mg may put an individual into a comatose state, and 70 mg may induce seizures.
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	\|}		\|}

	= Duration =		== Duration ==

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	= Effects =		== Effects ==

	Behavioural effects can vary by dosage. Low doses produce a numbness in the extremities and intoxication, characterized by staggering, unsteady gait, slurred speech, bloodshot eyes, and loss of balance. Moderate doses (5–10 mg intranasal, or 0.01–0.02 mg/kg intramuscular or intravenous) will produce analgesia and anesthesia. High doses may lead to convulsions. Users frequently do not know how much of the drug they are taking due to its potency and tendency of the drug to be made illegally in uncontrolled conditions.		Behavioural effects can vary by dosage. Low doses produce a numbness in the extremities and intoxication, characterized by staggering, unsteady gait, slurred speech, bloodshot eyes, and loss of balance. Moderate doses (5–10 mg intranasal, or 0.01–0.02 mg/kg intramuscular or intravenous) will produce analgesia and anesthesia. High doses may lead to convulsions. Users frequently do not know how much of the drug they are taking due to its potency and tendency of the drug to be made illegally in uncontrolled conditions.
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	Psychological effects include severe changes in body image, loss of ego boundaries, paranoia and depersonalization. Hallucinations, euphoria, and suicidal impulses are also reported, as well as occasional aggressive behavior. Like many other drugs, phencyclidine has been known to alter mood states in an unpredictable fashion, causing some individuals to become detached, and others to become animated. PCP may induce feelings of strength, power, and invulnerability as well as a numbing effect on the mind.		Psychological effects include severe changes in body image, loss of ego boundaries, paranoia and depersonalization. Hallucinations, euphoria, and suicidal impulses are also reported, as well as occasional aggressive behavior. Like many other drugs, phencyclidine has been known to alter mood states in an unpredictable fashion, causing some individuals to become detached, and others to become animated. PCP may induce feelings of strength, power, and invulnerability as well as a numbing effect on the mind.

	== Postive ==		=== Postive ===

	* Increase in energy		* Increase in energy
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	* Can improve depression		* Can improve depression

	== Neutral ==		=== Neutral ===

	* Increased salivation		* Increased salivation
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	* Nystagmus (rhythmic eye movement)		* Nystagmus (rhythmic eye movement)

	== Negative ==		=== Negative ===

	* Disturbing hallucinations and/or delusions		* Disturbing hallucinations and/or delusions
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	*Potential for violence or unpredictable behavior		*Potential for violence or unpredictable behavior

	~~== Potentiators ==~~

	* Alchohol

	* Benzodiazpines

	~~== Interactions ==~~

	* Acts as a Central Nervous System depressant. Interacts negatively with the above potentiators

	= Harm Reduction =		== Harm Reduction ==

	If you think you are overdosing on PCP, please seek emergency medical attention immediately.		If you think you are overdosing on PCP, please seek emergency medical attention immediately.
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	See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.		See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.

	= Chemistry and Pharmacology =		=== Potentiators ===

			* Alchohol

			* Benzodiazpines

			=== Interactions ===

			* Acts as a Central Nervous System depressant. Interacts negatively with the above potentiators

			== Chemistry and Pharmacology ==

	In chemical structure, PCP is an arylcyclohexylamine derivative, and, in pharmacology, it is a member of the family of dissociative anesthetics. PCP works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA receptor and, like most antiglutamatergic hallucinogens, is significantly more dangerous than other categories of hallucinogens.		In chemical structure, PCP is an arylcyclohexylamine derivative, and, in pharmacology, it is a member of the family of dissociative anesthetics. PCP works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA receptor and, like most antiglutamatergic hallucinogens, is significantly more dangerous than other categories of hallucinogens.
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	There are more than 125 known derivates of PCP.		There are more than 125 known derivates of PCP.

	= Legal status =		== Legal status ==

	PCP is Schedule II in the United States. This means it is illegal to sell without a DEA license and illegal to buy or possess without a license or prescription.		PCP is Schedule II in the United States. This means it is illegal to sell without a DEA license and illegal to buy or possess without a license or prescription.
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	It is also banned in the UK, Germany, Poland, Canada and New Zealand.		It is also banned in the UK, Germany, Poland, Canada and New Zealand.

	= Links =		== Links ==

	[https://en.wikipedia.org/wiki/Phencyclidine Wikipedia ]		[https://en.wikipedia.org/wiki/Phencyclidine Wikipedia ]

Roi: /* Harm Reduction */

2014-08-05T15:01:20Z

Harm Reduction

← Older revision		Revision as of 10:01, 5 August 2014
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	If you think you are overdosing on PCP, please seek emergency medical attention immediately.		If you think you are overdosing on PCP, please seek emergency medical attention immediately.

	* At an Emergency Room, Doctors usually provide ~1mg Lorazepam and 1-10mg Haloperidol (anti-psychotic, to combat PCP overdoses and violent or unpredictable behavior).		* At an Emergency Room, Doctors usually provide 1mg Lorazepam (benzodiazepine) and 1-10mg Haloperidol (anti-psychotic) to combat PCP overdoses and violent or unpredictable behavior.

	* Do not drive or operate heavy machinery.		* Do not drive or operate heavy machinery.

Trainwreck: /* Harm Reduction */

2014-08-05T14:49:21Z

Harm Reduction

← Older revision		Revision as of 09:49, 5 August 2014
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	= Harm Reduction =		= Harm Reduction =

	~~See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for~~ general ~~information~~.		If you think you are overdosing on PCP, please seek emergency medical attention immediately.

			* At an Emergency Room, Doctors usually provide ~1mg Lorazepam and 1-10mg Haloperidol (anti-psychotic, to combat PCP overdoses and violent or unpredictable behavior).

			* Do not drive or operate heavy machinery.

			* Avoid walking or moving in general if possible.

			* Always experiment with drugs with a sober friend in a safe place. Start low, increase until desired effect

	~~At an Emergency Room, Doctors usually provide ~1mg Lorazepam and 1~~-~~10mg Haloperidol (anti-psychotic, to combat PCP overdoses and violent or unpredictable behavior)~~.		* A full stomach may lead to nausea; consider fasting 3-4+ hours before usage.

	~~If you think you are overdosing on PCP, please seek emergency medical attention immediately~~.		See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.

	= Chemistry and Pharmacology =		= Chemistry and Pharmacology =

Trainwreck: /* Harm Reduction */

2014-08-05T14:47:56Z

Harm Reduction

← Older revision		Revision as of 09:47, 5 August 2014
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	*Potential for violence or unpredictable behavior		*Potential for violence or unpredictable behavior

	~~= Harm Reduction =~~

	* Do not drive or operate heavy machinery.

	* Avoid walking or moving in general if possible.

	* Always experiment with drugs with a sober friend in a safe place

	* A full stomach may lead to nausea; consider fasting 3-4+ hours before usage.

	== Potentiators ==		== Potentiators ==

Roi: /* Links */

2014-08-05T14:41:56Z

Links

← Older revision		Revision as of 09:41, 5 August 2014
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	= Links =		= Links =

	https://en.wikipedia.org/wiki/Phencyclidine		[https://en.wikipedia.org/wiki/Phencyclidine Wikipedia ]

	https://en.wikipedia.org/wiki/Olney%27s_lesions		[https://en.wikipedia.org/wiki/Olney%27s_lesions Olney's lesions]

	https://www.erowid.org/chemicals/pcp/		[https://www.erowid.org/chemicals/pcp/ Erowid]

	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859735/		[http://www.ncbi.nlm.nih.gov/pubmed/22970762 Use of haloperidol in PCP-intoxicated individuals.]

			[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859735/ Phencyclidine Intoxication and Adverse Effects: A Clinical and Pharmacological Review of an Illicit Drug]

	[[Category:Drugs]]		[[Category:Drugs]]

	[[Category:Dissociative]]		[[Category:Dissociative]]

Roi: /* Harm Reduction */

2014-08-05T14:40:14Z

Harm Reduction

← Older revision		Revision as of 09:40, 5 August 2014
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	See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.		See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.

	At an Emergency Room. Doctors usually provide ~1mg ~~Ativan (lorazepam/ benzodiazepine)~~ and 1-10mg ~~Haldol~~ (anti-psychotic, to combat PCP overdoses and violent or unpredictable behavior.		At an Emergency Room, Doctors usually provide ~1mg Lorazepam and 1-10mg Haloperidol (anti-psychotic, to combat PCP overdoses and violent or unpredictable behavior).

	If you think you are overdosing on PCP, please seek emergency medical attention immediately.		If you think you are overdosing on PCP, please seek emergency medical attention immediately.

	~~Source: Drugs Inc. and http://www.ncbi.nlm.nih.gov/pubmed/22970762~~

	= Chemistry and Pharmacology =		= Chemistry and Pharmacology =

Roi: /* General Information */

2014-08-05T14:38:36Z

General Information

← Older revision		Revision as of 09:38, 5 August 2014
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	= General Information =		= General Information =

	PCP is a powerful dissociative. The acronym PCP stems from its organic name 1-(1-phenylcyclohexyl) piperidine, which alludes to its relatively simple production from the arylcyclohexylamine piperidine. It is best known for stories of the strange and sometimes violent behavior of people under its influence. However, studies by the Drug Abuse Warning Network in the 1970s show that media reports of PCP-induced violence are greatly exaggerated and that incidents of violence are unusual and often (but not always) limited to individuals with reputations for aggression regardless of drug use. It has been implicated as a major cause of psychiatric decompensation and has a number of clinical syndromes described in the literature. In addition, PCP has been shown to cause significant medical morbidity and mortality. It is found in a variety of forms including crystals/powder, tablets, and liquid. Recently it seems to be available on the underground market most commonly as cannabis joints, regular cigarettes or cannabis leaf dipped in liquid PCP~~....~~and usually marketed as something else, seldom as 'PCP'		PCP is a powerful dissociative. The acronym PCP stems from its organic name 1-(1-phenylcyclohexyl) piperidine, which alludes to its relatively simple production from the arylcyclohexylamine piperidine. It is best known for stories of the strange and sometimes violent behavior of people under its influence. However, studies by the Drug Abuse Warning Network in the 1970s show that media reports of PCP-induced violence are greatly exaggerated and that incidents of violence are unusual and often (but not always) limited to individuals with reputations for aggression regardless of drug use. It has been implicated as a major cause of psychiatric decompensation and has a number of clinical syndromes described in the literature. In addition, PCP has been shown to cause significant medical morbidity and mortality. It is found in a variety of forms including crystals/powder, tablets, and liquid. Recently PCP seems to be available on the underground market most commonly in form of cannabis joints, regular cigarettes or cannabis leaf which are dipped in liquid PCP, and usually marketed as something else, seldom as 'PCP'.

	== History ==		== History ==