Opioid Notes - Revision history

Sleep: Majorly fucked up the page with my edit.

2018-01-22T07:55:17Z

Majorly fucked up the page with my edit.

Sleep at 13:05, 6 November 2017

2017-11-06T13:05:48Z

Sleep at 13:02, 6 November 2017

2017-11-06T13:02:41Z

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Sleep: I'm doing a test

2017-11-06T13:02:02Z

I'm doing a test

Show changes

Sleep: Removed a few.

2017-02-21T03:30:15Z

Removed a few.

Sleep at 22:31, 23 September 2016

2016-09-23T22:31:50Z

← Older revision		Revision as of 17:31, 23 September 2016
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	:Eseroline - Metabolite of the ACh inhibitor physostigmine but potent μ agonist.		:Eseroline - Metabolite of the ACh inhibitor physostigmine but potent μ agonist.
	:Hodgkinsine - Alkaloid found in Psychotria colorata plants. Has antiviral, antibacterial and antifungal properties. Also μ opioid agonist & NMDA antagonist.		:Hodgkinsine - Alkaloid found in Psychotria colorata plants. Has antiviral, antibacterial and antifungal properties. Also μ opioid agonist & NMDA antagonist.
	:Ibogaine - ~~Addiction CURE.~~ HT2a agonist, κ opioid agonist, NMDA antagonist.		:Ibogaine - HT2a agonist, κ opioid agonist, NMDA antagonist.
	:Mitragynine - Alkaloid in ~~KratoMorphine~~. Fairly selective μ agonist but little affinity for δ & κ.		:Mitragynine - Alkaloid in Kratom. Fairly selective μ agonist but little affinity for δ & κ.
	:Noribogaine - Metabolite of Ibogaine. Potent SRI, κ antagonist, weak μ full agonist.		:Noribogaine - Metabolite of Ibogaine. Potent SRI, κ antagonist, weak μ full agonist.
	:Voacangine - Precursor to Ibogine used by iboga plant. Displays similar effects towards addiction as Ibogaine.		:Voacangine - Precursor to Ibogine used by iboga plant. Displays similar effects towards addiction as Ibogaine.

Sleep: Meh. Added Pirinitramides.

2016-08-14T14:42:16Z

Meh. Added Pirinitramides.

← Older revision		Revision as of 09:42, 14 August 2016
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	:Dihydroetorphine -1000-12000x potency of M depending on RoA. Less addictive than other opioids and is used in a similar fashion to Subutex in China.		:Dihydroetorphine -1000-12000x potency of M depending on RoA. Less addictive than other opioids and is used in a similar fashion to Subutex in China.
	:Etorphine - 1000-3000x potency of Morphine. μ, κ & δ opioid agonist. weak affinity for ORL1 nociceptin/orphanin FQ receptor.		:Etorphine - 1000-3000x potency of Morphine. μ, κ & δ opioid agonist. weak affinity for ORL1 nociceptin/orphanin FQ receptor.

			== Pirinitramides ==
			:Bezitramide - Prodrug that hydrolyzises in the GI tract to despropionyl-bezitramide. Pulled from the NL's in 2004 after fatal overdose cases.
			:Piritramide - 0.65-0.75x M but still effect is strong and long lasting. Has a small but dedicated fanclub on the 'street'

			== Benzimidazoles ==
			:Etonitazene - Most potent nitazene at 1000-1500x potency of M. Strange structure, abstract from other opioids, with an indole body.
			:xxxNitazene - Differing potencies depending on substitution on the lower 4-phenyl.


	== Indoles ==		== Indoles ==

Sleep: I can't spell sometimes, and maybe someday I'll figure out if Bezitramide is Burgodin or not.

2016-08-14T14:34:15Z

I can't spell sometimes, and maybe someday I'll figure out if Bezitramide is Burgodin or not.

← Older revision		Revision as of 09:34, 14 August 2016
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	== Moramides ==		== Moramides ==
	:Palfium (~~Dextomoramide~~) - 3x potency of M but shorter acting. High BA & fast acting, oral feels like shooting. Low LD50 & inconsistent potency (one day you may need 5mg, next day 3mg)		:Palfium (Dextromoramide) - 3x potency of M but shorter acting. High BA & fast acting, oral feels like shooting. Low LD50 & inconsistent potency (one day you may need 5mg, next day 3mg)

	== Thiambutens ==		== Thiambutens ==

Sleep: My internet sucks, and I fixed something that didn't look visually pleasing.

2015-11-02T15:31:51Z

My internet sucks, and I fixed something that didn't look visually pleasing.

← Older revision		Revision as of 10:31, 2 November 2015
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	:3-Hydroxymorphinan: l (+) Norlevorphanol >< Nordextrorphan (-) d --> l = :Opioid >< d = Nootropic.		:3-Hydroxymorphinan: l (+) Norlevorphanol >< Nordextrorphan (-) d --> l = :Opioid >< d = Nootropic.
	└--> Racemic mix of both isomers, embodying their properties.		:└--> Racemic mix of both isomers, embodying their properties.

	:Oxilorphan: μ antagonist & weak partial κ agonist.		:Oxilorphan: μ antagonist & weak partial κ agonist.
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	== Diphenylmethylpiperazines ==		== Diphenylmethylpiperazines ==
	:BW373U86 - Selective δ agonist at 15x stronger affinity. Analgesic and anti-depressant properties along with BDNF release. Produces convulsions at high doses and reverses respiratory depression produced by μ ~~agonisMorphine~~. Also protects heart muscle cells from death during oxygen deprivation, a result of heart attacks.		:BW373U86 - Selective δ agonist at 15x stronger affinity. Analgesic and anti-depressant properties along with BDNF release. Produces convulsions at high doses and reverses respiratory depression produced by μ agonist Morphine. Also protects heart muscle cells from death during oxygen deprivation, a result of heart attacks.
	:DPI-227 - Highly selective δ agonist with antidepressant effects but produces fewer convulsions than most other dugs in it's family.		:DPI-227 - Highly selective δ agonist with antidepressant effects but produces fewer convulsions than most other dugs in it's family.
	:DPI-3290 - Potent δ & μ agonist but produces little respiratory depression.		:DPI-3290 - Potent δ & μ agonist but produces little respiratory depression.

Supra at 15:25, 2 November 2015

2015-11-02T15:25:05Z

← Older revision		Revision as of 10:25, 2 November 2015
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	:R-30490 - Analogue of carfentanil. Most selective μ agonist of all fentanyl analogues.		:R-30490 - Analogue of carfentanil. Most selective μ agonist of all fentanyl analogues.
	:Remifentanil - Potent ultra short acting fent. analogue. Potency from between 20 and 100ug. Used in medicine as an anaesthetic under Ultiva.		:Remifentanil - Potent ultra short acting fent. analogue. Potency from between 20 and 100ug. Used in medicine as an anaesthetic under Ultiva.
	:Sufentanil - 5-~~10x~~ potency of ~~fentanyl~~.		:Sufentanil - 150-200x the potency of Morphine.

	== Opipavine Derivatives ==		== Opipavine Derivatives ==

← Older revision		Revision as of 08:05, 6 November 2017
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	BENZOMORPHANS		BENZOMORPHANS

	Butinazocine - benzomorphan opioid that was never marketed~~-----------------\ The Benzomorphans have~~		Butinazocine - benzomorphan opioid that was never marketed
	Carbazocine - benzomorphan opioid that was never marketed ~~\ to be my favourite structures.~~		Carbazocine - benzomorphan opioid that was never marketed
	Etazocine - partial opioid agonist with mixed ant.-ag. effects. low potency ~~\_ The Cubist narcotics.~~		Etazocine - partial opioid agonist with mixed ant.-ag. effects. low potency
	Ethylketocyclozocine - partial opioid agonist with mixed ant.-ag. effects ~~The Picassopiates.~~		Ethylketocyclozocine - partial opioid agonist with mixed ant.-ag. effects
	Ibazocine - benzomorphan opioid that was never marketed ~~They serve no real function~~		Ibazocine - benzomorphan opioid that was never marketed
	Moxazocine - 10x potency of M, partial/mixed ant.-ag. ~~_ except to look pretty to~~		Moxazocine - 10x potency of M, partial/mixed ant.-ag.
	Tonazocine - partial agonist at μ & δ, no adverse effects on breathing ~~/ afficionados such as I.~~		Tonazocine - partial agonist at μ & δ, no adverse effects on breathing
	Volazocine - benzomorphan opioid that was never marketed ~~/ As do I to afficionados such~~		Volazocine - benzomorphan opioid that was never marketed
	Fluorophen - radioligand, full μ agonist (6x M) & lower affinity for δ ~~/ as they, and they to afficonados~~		Fluorophen - radioligand, full μ agonist (6x M) & lower affinity for δ
	Zenazocine - partial agonist at μ & δ~~-------------------------------------/ such as we, and we are such afficionados.~~		Zenazocine - partial agonist at μ & δ
	Eptazocine - Japanese κ agonist & μ antagonist		Eptazocine - Japanese κ agonist & μ antagonist
	Pentazocine - mixed ant.-ag. (-) is the κ agonist side, the (+) displays 10x the affinity for sigma receptors. NO μ agonism		Pentazocine - mixed ant.-ag. (-) is the κ agonist side, the (+) displays 10x the affinity for sigma receptors. NO μ agonism
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	Benzethidine - 4-phenylpiperidine analogue of pethidine. Probably somewhat more potent and euphoric. Never scripted.		Benzethidine - 4-phenylpiperidine analogue of pethidine. Probably somewhat more potent and euphoric. Never scripted.
	Carperidine - fairly normal opiate but unused in medicine and currently LEGAL (08/06/2013)		Carperidine - fairly normal opiate but unused in medicine and currently LEGAL (08/06/2013)
	Furethidine - 4-Phenylpiperidine analogue of pethidine. Probably a lot more potent and abuse prone. Never prescribed.		Furethidine - 4-Phenylpiperidine analogue of pethidine. Probably a lot more potent and abuse-prone. Never prescribed.
	Morpheridine - related to meperidine but 4x the potency and does not cause convulsions		Morpheridine - related to meperidine but 4x the potency and does not cause convulsions
	Phenoperidine - 20-200x the potency of Pethidine. Less hypnotic and than morphine but more emetic (nausea). This can be cured by Haloperidol.		Phenoperidine - 20-200x the potency of Pethidine. Less hypnotic and than morphine but more emetic (nausea). This can be cured by Haloperidol.

← Older revision		Revision as of 22:30, 20 February 2017
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	:3-HO-BCP - Substitutes for both cocaine and morphine at ~5mg (made-up).		:3-HO-BCP - Substitutes for both cocaine and morphine at ~5mg (made-up).
	:AD-1211 - Structure looks unrelated to /most/ other opioid drugs. Mixed Agonist-antagonist at opioid recepts similar to pentazocine. Little to no developement of tolerance/dependence in animal studies.		:AD-1211 - Structure looks unrelated to /most/ other opioid drugs. Mixed Agonist-antagonist at opioid recepts similar to pentazocine. Little to no developement of tolerance/dependence in animal studies.
	:AH-7921 - Selective μ agonist, with 80% potency of Morphine. Distributed as an RC, TRs show that it has very little euphoria, indicating euphoria comes from somewhere else. Perhaps sigma? Other opioids are heavily potentiated by it. Perhaps μ agonism is purely analgesic and high comes from a combination of μ & δ with each multiplying the affect of the other. This indicates ultimate opioid high would be moderately selective δ agonist.
	:Azaprocin - Azaprocin - ~10x potency of Morphine. Faster onset and short duration of actin. Discoved in 1963, never been marketed. The derivative subbed on the phenyl ring with a p-nitro group would be more potent by roughly 2.5. (So 25x potency of M) The open ringed 2,6-dimethylpiperazine analouges would also be active.		:Azaprocin - Azaprocin - ~10x potency of Morphine. Faster onset and short duration of actin. Discoved in 1963, never been marketed. The derivative subbed on the phenyl ring with a p-nitro group would be more potent by roughly 2.5. (So 25x potency of M) The open ringed 2,6-dimethylpiperazine analouges would also be active.
	:BRL-52537 - Highly potent and selective κ agonist. Neuroprotective.		:BRL-52537 - Highly potent and selective κ agonist. Neuroprotective.
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	:Tapentadol - μ & σ agonist & SNRI. Potency in between Morphine & Tramadol.		:Tapentadol - μ & σ agonist & SNRI. Potency in between Morphine & Tramadol.
	:Tifluadom - Benzo derivative but without GABAa agonism. Instead selective κ agonism.		:Tifluadom - Benzo derivative but without GABAa agonism. Instead selective κ agonism.
	~~:U-47700 - Overlays betaprodine, 7.5x morphine.~~
	:U-50488 - Highly selective κ agonist with analgesic effects.		:U-50488 - Highly selective κ agonist with analgesic effects.
	:U-69,593 - Potent and selective κ1 agonist. Produces: Antinociception, anti-inflammation, anxiolysis (low doses), respiratory depression & diuresis. Also inhibits periphery oxytocin secretion. Not sure if hallucinogenic.		:U-69,593 - Potent and selective κ1 agonist. Produces: Antinociception, anti-inflammation, anxiolysis (low doses), respiratory depression & diuresis. Also inhibits periphery oxytocin secretion. Not sure if hallucinogenic.
	~~:W-15 - 5.4x Morphine. RC.~~
	:W-18 - 10,000x potency of M, structure abstract from any other drug. These super potent opioids are used in vetenarian practice for tranquilising elephants.		:W-18 - 10,000x potency of M, structure abstract from any other drug. These super potent opioids are used in vetenarian practice for tranquilising elephants.