Methoxetamine - Revision history

Trees: removed pseudoscientic nonsense, added cardiotoxicity bit

2018-11-07T15:12:39Z

removed pseudoscientic nonsense, added cardiotoxicity bit

← Older revision		Revision as of 10:12, 7 November 2018
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	== Harm Reduction ==		== Harm Reduction ==
	MXE ~~can linger for quite some time in~~ the ~~body~~, ~~It is poorly metabolized~~. ~~A detox is necessary to remove it completely. A recommendable detox consists of food grade diatomaceous earth, borax (or boron) and kelp (iodine source)~~
			A recent [https://www.ncbi.nlm.nih.gov/pubmed/30377924 study] on rats indicates that MXE may have harmful effects on the cardiovascular system, and therefor should probably be avoided by anyone with any history of cardiovascular issues.

	See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.		See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.

Scribe: /* Negative */

2016-04-04T21:29:57Z

Negative

← Older revision		Revision as of 16:29, 4 April 2016
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	* Loss of consciousness		* Loss of consciousness
	* Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)		* Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)
			* Entity contact

	== Harm Reduction ==		== Harm Reduction ==

Scribe: /* Harm Reduction */ detox info+interactions

2016-04-04T21:28:47Z

Harm Reduction: detox info+interactions

← Older revision		Revision as of 16:28, 4 April 2016
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	== Harm Reduction ==		== Harm Reduction ==
			MXE can linger for quite some time in the body, It is poorly metabolized. A detox is necessary to remove it completely. A recommendable detox consists of food grade diatomaceous earth, borax (or boron) and kelp (iodine source)

	See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.		See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.

	=== Interactions ===		=== Interactions ===
			MXE is extremely dangerous in combination with alcohol and can cause fatal apnea or respiratory depression.
			Even residual MXE can potentiate the effects of 5ht agonists.
	[[Drug Combinations]]		[[Drug Combinations]]

Reality at 16:55, 3 April 2016

2016-04-03T16:55:19Z

@@ Line 4: / Line 4: @@
 == Dosage ==
-{| class="wikitable"
+{{#tdose: mxe }}
 == Duration ==

Reality at 17:09, 27 March 2016

2016-03-27T17:09:28Z

← Older revision		Revision as of 12:09, 27 March 2016
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	[[File:Mxe.jpg\|200px\|~~right~~]]		[[File:Mxe.jpg\|200px\|left]]
	'''Methoxetamine''' (MXE, 3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor (SRI). The N-Ethyl group on this compound increases potency.		'''Methoxetamine''' (MXE, 3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor (SRI). The N-Ethyl group on this compound increases potency.

GrimReaper at 15:32, 10 March 2015

2015-03-10T15:32:02Z

← Older revision		Revision as of 10:32, 10 March 2015
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	[[File:Mxe.jpg\|200px\|right]]		[[File:Mxe.jpg\|200px\|right]]
	Methoxetamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor (SRI). The N-Ethyl group on this compound increases potency.		'''Methoxetamine''' (MXE, 3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor (SRI). The N-Ethyl group on this compound increases potency.

	= Dosage =		== Dosage ==

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	= Duration =		== Duration ==

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	= Effects =		== Effects ==

	== Positive ==		=== Positive ===
	* Euphoria, mood lift		* Euphoria, mood lift
	* Sense of calm and serenity		* Sense of calm and serenity
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	* Out-of-body experience (less intense then ketamine)		* Out-of-body experience (less intense then ketamine)

	== Neutral ==		=== Neutral ===
	* Distortion or loss of sensory perceptions (common)		* Distortion or loss of sensory perceptions (common)
	* Dissociation of mind from body		* Dissociation of mind from body
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	* Confusion, disorientation		* Confusion, disorientation

	== Negative ==		=== Negative ===
	* Risk of psychological dependency		* Risk of psychological dependency
	* Nasal discomfort upon insufflation		* Nasal discomfort upon insufflation
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	* Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)		* Depression of heart rate and respiration (risk increases with increased dose or when combined with depressants)

	= Harm Reduction =		== Harm Reduction ==

	See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.		See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.

	== Interactions ==		=== Interactions ===
	[[Drug Combinations]]		[[Drug Combinations]]

	= Chemistry and Pharmacology =		== Chemistry and Pharmacology ==

	Examination of MXE molecule showed that, similar to [[Ketamine]], the 2 isomers have totally different effects with the (S) having potent NMDA activity (when the -OCH3 is deprotected to -OH, it gets stronger) while the (R) isomer has SRI effects and possibly a opioid metabolite.		Examination of MXE molecule showed that, similar to [[Ketamine]], the 2 isomers have totally different effects with the (S) having potent NMDA activity (when the -OCH3 is deprotected to -OH, it gets stronger) while the (R) isomer has SRI effects and possibly a opioid metabolite.
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	MXE is generally sold racemic.		MXE is generally sold racemic.

	= Legal status=		== Legal status==

	Methoxetamine is illegal in the US states Arizona<ref>http://www.azleg.gov/DocumentsForBill.asp?Session_ID=112&Bill_Number=HB2453</ref>, Florida<ref>http://www.leg.state.fl.us/Statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html</ref>, Indiana<ref>http://www.in.gov/legislative/ic/2010/title35/ar31.5/ch2.html</ref>, Louisiana<ref>http://www.legis.la.gov/legis/ViewDocument.aspx?d=850979&n=HB10%20Act</ref>, Minnesota<ref>https://www.revisor.mn.gov/statutes/?id=152.02</ref>, North Dakota<ref>http://www.legis.nd.gov/cencode/t19c03-1.pdf?20140721032549</ref>, Ohio<ref>http://www.legislature.state.oh.us/BillText130/130_HB_315_RH_N.html</ref> and Virginia<ref>http://lis.virginia.gov/cgi-bin/legp604.exe?000+cod+54.1-3446</ref>. It is also banned in Brazil, France, Germany, Japan, Russia and the UK<ref>http://www.legislation.gov.uk/uksi/2013/239/contents/made</ref>.		Methoxetamine is illegal in the US states Arizona<ref>http://www.azleg.gov/DocumentsForBill.asp?Session_ID=112&Bill_Number=HB2453</ref>, Florida<ref>http://www.leg.state.fl.us/Statutes/index.cfm?App_mode=Display_Statute&URL=0800-0899/0893/0893.html</ref>, Indiana<ref>http://www.in.gov/legislative/ic/2010/title35/ar31.5/ch2.html</ref>, Louisiana<ref>http://www.legis.la.gov/legis/ViewDocument.aspx?d=850979&n=HB10%20Act</ref>, Minnesota<ref>https://www.revisor.mn.gov/statutes/?id=152.02</ref>, North Dakota<ref>http://www.legis.nd.gov/cencode/t19c03-1.pdf?20140721032549</ref>, Ohio<ref>http://www.legislature.state.oh.us/BillText130/130_HB_315_RH_N.html</ref> and Virginia<ref>http://lis.virginia.gov/cgi-bin/legp604.exe?000+cod+54.1-3446</ref>. It is also banned in Brazil, France, Germany, Japan, Russia and the UK<ref>http://www.legislation.gov.uk/uksi/2013/239/contents/made</ref>.

	= Links =		== Links ==

	[https://en.wikipedia.org/wiki/Methoxetamine Wikipedia]		[https://en.wikipedia.org/wiki/Methoxetamine Wikipedia]
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	[http://reddit.com/r/Drugs/comments/o9wam/rdrugs_ama_series_mxe_methoxetamine/?sort=top /r/Drugs FAQ]		[http://reddit.com/r/Drugs/comments/o9wam/rdrugs_ama_series_mxe_methoxetamine/?sort=top /r/Drugs FAQ]

	= References =		== References ==

	<references />		<references />

Sleep at 20:16, 23 December 2014

2014-12-23T20:16:38Z

← Older revision		Revision as of 15:16, 23 December 2014
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	[[Category:Drugs]]		[[Category:Drugs]]
	[[Category:Dissociative]]		[[Category:Dissociative]]
			[[Category:Research Chemical]]

CustaiCo: harm reduction links to category section

2014-07-29T08:12:29Z

harm reduction links to category section

← Older revision		Revision as of 03:12, 29 July 2014
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	= Harm Reduction =		= Harm Reduction =
	* Avoid driving at all costs.
	* Avoid walking or moving around in general ~~if you are on a medium to hole dose.~~		See [[Dissociatives#Harm_Reduction\|Dissociative Harm Reduction]] for general information.
	* Taking this on a non-empty substance could lead to nausea.
	* Extreme disorientation can be expected on higher doses. Avoid movement when possible.

	== Interactions ==		== Interactions ==

Physical: /* Harm Reduction */

2014-07-21T15:55:38Z

Harm Reduction

← Older revision		Revision as of 10:55, 21 July 2014
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	* Avoid walking or moving around in general if you are on a medium to hole dose.		* Avoid walking or moving around in general if you are on a medium to hole dose.
	* Taking this on a non-empty substance could lead to nausea.		* Taking this on a non-empty substance could lead to nausea.
			* Extreme disorientation can be expected on higher doses. Avoid movement when possible.

	== Interactions ==		== Interactions ==

CustaiCo: Added MXE jpg

2014-07-21T10:41:32Z

Added MXE jpg

← Older revision		Revision as of 05:41, 21 July 2014
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			[[File:Mxe.jpg\|200px\|right]]
	Methoxetamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor (SRI). The N-Ethyl group on this compound increases potency.		Methoxetamine (3-MeO-2-Oxo-PCE) is a near chemical analogue of [[Ketamine]] and [[PCP]]. It was first publicly reported in 2010. Some say it's similar to Ketamine or high doses of DXM. Methoxetamine differs from many dissociatives such as ketamine and phencyclidine that were developed as pharmaceuticals in that it was designed specifically for grey market distribution, making it a rare instance of a true designer drug. It has been shown to act as an NMDA receptor antagonist and unlike ketamine also acts as Serotonin Reuptake Inhibitor (SRI). The N-Ethyl group on this compound increases potency.