MDMA - Revision history

Toasterlizard: Reverted edits by Dumbdumb123 (talk) to last revision by Anythingnoniding

2018-10-09T22:09:26Z

Reverted edits by Dumbdumb123 (talk) to last revision by Anythingnoniding

Dumbdumb123: Goodbye moonmen

2018-10-09T22:01:11Z

Goodbye moonmen

← Older revision		Revision as of 17:01, 9 October 2018
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	~~[[File:Mdma.jpg\|thumb\|300px\|MDMA Crystals]]~~		=Goodbye moonmen=

	'''MDMA''' (3,4-methylenedioxy-N-Methylamphetamine) is an popular drug of the phenethylamine and amphetamine class known for its empathogenic, euphoric, and stimulant effects, and has also been used in psychotherapy. It most frequently comes in tablet form, although it is also found in capsules or as powder. MDMA is also known as Ecstasy, Molly, XTC, E and several other names.

	Because MDMA is so popular and because it goes well with dance parties, the demand for it usually exceeds supply, especially at any given location on any given night. This creates an opening for unscrupulous individuals to sell virtually anything as 'ecstasy'. While 'ecstasy' is the popular name for MDMA, the functional definition of ecstasy is any pill represented as MDMA on the street. Ecstasy pills are notoriously unreliable in content, more so than most other street drugs, and commonly contain either caffeine, ephedrine, amphetamines, other MDXX's, DXM, or in rare cases DOX's, and don't necessarily contain MDMA or any psychoactive. They can also contain very neurotoxic substances (such as PMA, 4-CA, among many others). This problem has led to the development of simple MDMA [[Test Kits]] that may help give the user a general sense of the content of a pill.

	~~The experience is often called rolling.~~

	=Goodbye moonmen=		=Goodbye moonmen=

Dumbdumb123: Goodbye moonmen

2018-10-09T22:00:56Z

Goodbye moonmen

← Older revision		Revision as of 17:00, 9 October 2018
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	=Goodbye moonmen=		=Goodbye moonmen=

	= ~~Harm Reduction~~ =		=Goodbye moonmen=

	* MDMA rapidly builds tolerance, depletes serotonin and compounds neurotoxicity issues. Look for other drugs and avoid using MDMA more than once every few months.

	* Ecstasy tablets are notoriously impure, often containing chemicals other than MDMA. Check out [http://www.ecstasydata.org/ EcstasyData] and [http://pillreports.com/ Pill Reports] for pill testing results. Buy a [[Test Kit]]!

	~~== Health risks ==~~

	As with many drugs, there are some serious risks associated with taking MDMA affecting people with existing health conditions, or in certain cases people who are otherwise very healthy. It is not advisable to take MDMA if any of the following apply to you:
	* Health issues with the Heart, Kidneys or Liver
	* High blood pressure
	* History of having a stroke or heart attack

	~~In rare cases MDMA can cause seizures, overheating, hypothermia, dehydration or water poisoning. It is important to keep an eye on body temperature and hydration while under the effects of MDMA.~~

	~~There are some studies which suggest that long-term overuse and abuse of MDMA can cause or increase depression.~~

	~~=== Interactions ===~~

	* MDMA can cause [[Serotonin Syndrome]] when combined with MAOIs. Refer to [[Drug combinations]] for more information.

	* [http://www.erowid.org/chemicals/mdma/mdma_info9.shtml SSRIs and SNRIs block most effects of MDMA.]

	~~== Chemistry and Pharmacology ==~~

	~~=== Neurotoxicity, by Borax ===~~

	* The neurotoxicity is [https://pay.reddit.com/r/drugs/wiki/mdmaneurotoxicity well established], but studies are largely on mice and rats with [http://www.bluelight.org/vb/threads/614514 higher dosages than humans tend to use].

	* There is an excellent run through of the pharmacodynamics of MDMA neurotoxicity [http://www.dancesafe.org/drug-information/is-mdma-neurotoxic/ here].

	* Overall what we know is that the neurotoxicity scales with dose, and is likely to do so exponentially as the body is caused to overheat more and has less anitoxidants to deal with metabolites.

	* We don't have any quantitative estimates about damage from normal human doses because it would not be ethical to dose people repeatedly just to see how much it damages them, and it's very hard to gather data from regular users because of the huge number of variables like alcohol and cannabis use, sleep deprivation, environment of MDMA use etc.

	* We know that long term users are not [http://jop.sagepub.com/content/24/2/175 mentally impaired] but those abusing the drug do show a reduced ability to enjoy it and suffer a more intense comedown, indicating that there is something going on at higher doses.

	* Another discussion about MDMA neurotoxicity can be found [https://pay.reddit.com/r/Drugs/comments/12v5f8/research_suggests_no_neurotoxicity_in_mdma/c6ye9xc here].

	~~=== MDMA purity myths, by Borax ===~~

	~~The 84% claims are based around either a poor understanding of the science or are a deliberate attempt to pass off inferior product as high quality.~~

	You should read [https://pay.reddit.com/r/Drugs/comments/xihdo/rdrugs_ama_series_mdma_aka_ecstasy_e_x_molly/c5moa3i this discussion], but basically if anyone claims their MDMA is 84% pure then they have performed no analysis at all and should not be trusted.

	With almost all, the name is an abbreviation for Drug.salt. In the case of MDMA, it is MDMA.HCl, amphetamine is usually amphetamine.H2SO4 and LSD is LSD.tartrate. Because these forms are ubiquitous, nobody bothers to mention the second bit because it's irrelevant. All doses you see for MDMA are referring to the HCl salt, which means that MDMA which is sold as "the purest you can get, 84%", is treated as 100% pure.

	The reason sellers do this is because they usually don't have very pure MDMA, and they want people to make the mistake you have made and take more to account for crappy product. It is dishonest, confusing and misleading and if you have a choice you should avoid this vendor.

	~~=== Production ===~~

	~~MDMA is generally synthesised from naturally occurring safrole, extracted from the sassafras tree, making it a semi-synthetic drug.~~

	~~== Legal Status ==~~

	MDMA is legally controlled in most of the world under the UN Convention on Psychotropic Substances and other international agreements, although exceptions exist for research and limited medical use. In general, the unlicensed use, sale or manufacture of MDMA are all criminal offences.

	~~== Images ==~~

	~~<gallery mode="packed-hover">~~
	~~Image:Mdma.jpg\|''MDMA Crystals''~~
	~~Image:Mdma2.jpg\|''MDMA Crystals''~~
	~~Image:Bitcoin.png\|''Bitcoin MDMA Pill''~~
	~~Image:Mdma3.png\|''MDMA Crystals''~~
	~~Image:Mdma7.jpg\|''MDMA Crystals''~~
	~~</gallery>~~

	~~== Links ==~~

	~~[https://pay.reddit.com/r/Borax/comments/w5c1x/a_stepbystep_guide_to_reducing_mdma_neurotoxicity/ A step-by-step guide to reducing MDMA neurotoxicity]~~

	~~[https://pay.reddit.com/r/drugs/wiki/mdmaneurotoxicity Studies on MDMA neurotoxicity]~~

	~~[https://pay.reddit.com/r/DrugNerds/comments/15m9sf/mdma_supplementation/ MDMA Supplementation]~~

	~~[https://www.erowid.org/chemicals/mdma/ Erowid MDMA vault]~~

	~~[https://rollsafe.org/ RollSafe - MDMA Info]~~

	~~[[Category:Drugs]]~~

	~~[[Category:Stimulant]]~~

Dumbdumb123: /* Goodbye moonmen */

2018-10-09T22:00:40Z

Goodbye moonmen

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 =Goodbye moonmen=
 =Goodbye moonmen=
 = Harm Reduction =

Dumbdumb123: Goodbye moonmen

2018-10-09T22:00:07Z

Goodbye moonmen

← Older revision		Revision as of 17:00, 9 October 2018
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	The experience is often called rolling.		The experience is often called rolling.

	== ~~History~~ ==		=Goodbye moonmen=
			=Goodbye moonmen=
	~~MDMA was first synthesized in 1912 by Merck chemist Anton Köllisch.~~		=Goodbye moonmen=
			=Goodbye moonmen=
	In the mid-1970s, Alexander Shulgin heard from his students about unusual effects of MDMA; among others, the drug had helped one of them to overcome his stutter. Intrigued, Shulgin synthesized MDMA and tried it himself in 1976. Two years later, he and David E. Nichols published the first report on the drug's psychotropic effect in humans. They described "altered state of consciousness with emotional and sensual overtones" that can be compared "to marijuana, and to psilocybin devoid of the hallucinatory component".		=Goodbye moonmen=
			=Goodbye moonmen=
	~~In the early 1980s the drug emerged in the parts of Europe and the United States.~~		=Goodbye moonmen=
			=Goodbye moonmen=
	MDMA was first proposed for scheduling by the Drug Enforcement Administration (DEA) in July 1984 and was classified as a Schedule I controlled substance in the U.S. on 31 May 1985; on an emergency basis. No double blind studies had yet been conducted as to the efficacy of MDMA for psychotherapy.		=Goodbye moonmen=
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	== Dosage ==		== Dosage ==

Anythingnoniding: Fix and update rollsafe link

2017-07-11T05:03:56Z

Fix and update rollsafe link

← Older revision		Revision as of 00:03, 11 July 2017
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	[https://www.erowid.org/chemicals/mdma/ Erowid MDMA vault]		[https://www.erowid.org/chemicals/mdma/ Erowid MDMA vault]

	[~~http~~://~~www.~~rollsafe.org/ RollSafe]		[https://rollsafe.org/ RollSafe - MDMA Info]

	[[Category:Drugs]]		[[Category:Drugs]]

	[[Category:Stimulant]]		[[Category:Stimulant]]

GrimReaper: /* Chemistry and Pharmacology */

2015-03-10T15:24:08Z

Chemistry and Pharmacology

← Older revision		Revision as of 10:24, 10 March 2015
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	* [http://www.erowid.org/chemicals/mdma/mdma_info9.shtml SSRIs and SNRIs block most effects of MDMA.]		* [http://www.erowid.org/chemicals/mdma/mdma_info9.shtml SSRIs and SNRIs block most effects of MDMA.]

	= Chemistry and Pharmacology =		== Chemistry and Pharmacology ==

	=== Neurotoxicity, by Borax ===		=== Neurotoxicity, by Borax ===

GrimReaper at 15:23, 10 March 2015

2015-03-10T15:23:45Z

← Older revision		Revision as of 10:23, 10 March 2015
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	[[File:Mdma.jpg\|thumb\|300px\|MDMA Crystals]]		[[File:Mdma.jpg\|thumb\|300px\|MDMA Crystals]]

	MDMA (3,4-methylenedioxy-N-Methylamphetamine) is an popular drug of the phenethylamine and amphetamine class known for its empathogenic, euphoric, and stimulant effects, and has also been used in psychotherapy. It most frequently comes in tablet form, although it is also found in capsules or as powder. MDMA is also known as Ecstasy, Molly, XTC, E and several other names.		'''MDMA''' (3,4-methylenedioxy-N-Methylamphetamine) is an popular drug of the phenethylamine and amphetamine class known for its empathogenic, euphoric, and stimulant effects, and has also been used in psychotherapy. It most frequently comes in tablet form, although it is also found in capsules or as powder. MDMA is also known as Ecstasy, Molly, XTC, E and several other names.

	Because MDMA is so popular and because it goes well with dance parties, the demand for it usually exceeds supply, especially at any given location on any given night. This creates an opening for unscrupulous individuals to sell virtually anything as 'ecstasy'. While 'ecstasy' is the popular name for MDMA, the functional definition of ecstasy is any pill represented as MDMA on the street. Ecstasy pills are notoriously unreliable in content, more so than most other street drugs, and commonly contain either caffeine, ephedrine, amphetamines, other MDXX's, DXM, or in rare cases DOX's, and don't necessarily contain MDMA or any psychoactive. They can also contain very neurotoxic substances (such as PMA, 4-CA, among many others). This problem has led to the development of simple MDMA [[Test Kits]] that may help give the user a general sense of the content of a pill.		Because MDMA is so popular and because it goes well with dance parties, the demand for it usually exceeds supply, especially at any given location on any given night. This creates an opening for unscrupulous individuals to sell virtually anything as 'ecstasy'. While 'ecstasy' is the popular name for MDMA, the functional definition of ecstasy is any pill represented as MDMA on the street. Ecstasy pills are notoriously unreliable in content, more so than most other street drugs, and commonly contain either caffeine, ephedrine, amphetamines, other MDXX's, DXM, or in rare cases DOX's, and don't necessarily contain MDMA or any psychoactive. They can also contain very neurotoxic substances (such as PMA, 4-CA, among many others). This problem has led to the development of simple MDMA [[Test Kits]] that may help give the user a general sense of the content of a pill.
Line 17:		Line 17:
	MDMA was first proposed for scheduling by the Drug Enforcement Administration (DEA) in July 1984 and was classified as a Schedule I controlled substance in the U.S. on 31 May 1985; on an emergency basis. No double blind studies had yet been conducted as to the efficacy of MDMA for psychotherapy.		MDMA was first proposed for scheduling by the Drug Enforcement Administration (DEA) in July 1984 and was classified as a Schedule I controlled substance in the U.S. on 31 May 1985; on an emergency basis. No double blind studies had yet been conducted as to the efficacy of MDMA for psychotherapy.

	= Dosage =		== Dosage ==

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	= Duration =		== Duration ==

	{\| class="wikitable"		{\| class="wikitable"
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	\|}		\|}

	= Effects =		== Effects ==

	== Postive ==		=== Postive ===

	* Mild to extreme mood lift, euphoria		* Mild to extreme mood lift, euphoria
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	* Analgesia, anti-nocioception, decreased pain perception		* Analgesia, anti-nocioception, decreased pain perception

	== Neutral ==		=== Neutral ===

	* Decreased appetite		* Decreased appetite
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	* Strong desire to do or want more when coming down		* Strong desire to do or want more when coming down

	== Negative ==		=== Negative ===

	Negative side effects increase with higher doses and frequent use.		Negative side effects increase with higher doses and frequent use.
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	* Small risk of death; approximately 2 per 100,000 new users have extreme negative reactions resulting in death (very rare)		* Small risk of death; approximately 2 per 100,000 new users have extreme negative reactions resulting in death (very rare)

	=== Hangover ===		==== Hangover ====

	Many users [http://www.erowid.org/chemicals/mdma/mdma_effects_hangover1.shtml report feeling extremely drained the day after MDMA use]. This 'day after' effect means for many MDMA users that they need to plan 2 days for the experience: one for the peak experience and one recovery day, with very little planned. Many users also experience some level of post-MDMA depression, often starting on the second day after the experience and lasting for up to 5 days. A small percentage of users report depressive symptoms for weeks afterwards. Alternately, some users report feeling better than normal for a week or so after taking MDMA. The negative after-effects of taking MDMA appear to be worse with higher frequencies of use, higher dosages, and perhaps total lifetime usage.		Many users [http://www.erowid.org/chemicals/mdma/mdma_effects_hangover1.shtml report feeling extremely drained the day after MDMA use]. This 'day after' effect means for many MDMA users that they need to plan 2 days for the experience: one for the peak experience and one recovery day, with very little planned. Many users also experience some level of post-MDMA depression, often starting on the second day after the experience and lasting for up to 5 days. A small percentage of users report depressive symptoms for weeks afterwards. Alternately, some users report feeling better than normal for a week or so after taking MDMA. The negative after-effects of taking MDMA appear to be worse with higher frequencies of use, higher dosages, and perhaps total lifetime usage.

	= Health risks =		= Harm Reduction =

			* MDMA rapidly builds tolerance, depletes serotonin and compounds neurotoxicity issues. Look for other drugs and avoid using MDMA more than once every few months.

			* Ecstasy tablets are notoriously impure, often containing chemicals other than MDMA. Check out [http://www.ecstasydata.org/ EcstasyData] and [http://pillreports.com/ Pill Reports] for pill testing results. Buy a [[Test Kit]]!

			== Health risks ==

	As with many drugs, there are some serious risks associated with taking MDMA affecting people with existing health conditions, or in certain cases people who are otherwise very healthy. It is not advisable to take MDMA if any of the following apply to you:		As with many drugs, there are some serious risks associated with taking MDMA affecting people with existing health conditions, or in certain cases people who are otherwise very healthy. It is not advisable to take MDMA if any of the following apply to you:
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	There are some studies which suggest that long-term overuse and abuse of MDMA can cause or increase depression.		There are some studies which suggest that long-term overuse and abuse of MDMA can cause or increase depression.

	= ~~Harm Reduction~~ =		=== Interactions ===

	* MDMA rapidly builds tolerance, depletes serotonin and compounds neurotoxicity issues. Look for other drugs and avoid using MDMA more than once every few months.

	* Ecstasy tablets are notoriously impure, often containing chemicals other than MDMA. Check out [http://www.ecstasydata.org/ EcstasyData] and [http://pillreports.com/ Pill Reports] for pill testing results. Buy a [[Test Kit]]!

	== ~~Interactions~~ ==

	* MDMA can cause [[Serotonin Syndrome]] when combined with MAOIs. Refer to [[Drug combinations]] for more information.		* MDMA can cause [[Serotonin Syndrome]] when combined with MAOIs. Refer to [[Drug combinations]] for more information.
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	= Chemistry and Pharmacology =		= Chemistry and Pharmacology =

	== Neurotoxicity, by Borax ==		=== Neurotoxicity, by Borax ===

	* The neurotoxicity is [https://pay.reddit.com/r/drugs/wiki/mdmaneurotoxicity well established], but studies are largely on mice and rats with [http://www.bluelight.org/vb/threads/614514 higher dosages than humans tend to use].		* The neurotoxicity is [https://pay.reddit.com/r/drugs/wiki/mdmaneurotoxicity well established], but studies are largely on mice and rats with [http://www.bluelight.org/vb/threads/614514 higher dosages than humans tend to use].
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	* Another discussion about MDMA neurotoxicity can be found [https://pay.reddit.com/r/Drugs/comments/12v5f8/research_suggests_no_neurotoxicity_in_mdma/c6ye9xc here].		* Another discussion about MDMA neurotoxicity can be found [https://pay.reddit.com/r/Drugs/comments/12v5f8/research_suggests_no_neurotoxicity_in_mdma/c6ye9xc here].

	== MDMA purity myths, by Borax ==		=== MDMA purity myths, by Borax ===

	The 84% claims are based around either a poor understanding of the science or are a deliberate attempt to pass off inferior product as high quality.		The 84% claims are based around either a poor understanding of the science or are a deliberate attempt to pass off inferior product as high quality.
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	The reason sellers do this is because they usually don't have very pure MDMA, and they want people to make the mistake you have made and take more to account for crappy product. It is dishonest, confusing and misleading and if you have a choice you should avoid this vendor.		The reason sellers do this is because they usually don't have very pure MDMA, and they want people to make the mistake you have made and take more to account for crappy product. It is dishonest, confusing and misleading and if you have a choice you should avoid this vendor.

	== Production ==		=== Production ===

	MDMA is generally synthesised from naturally occurring safrole, extracted from the sassafras tree, making it a semi-synthetic drug.		MDMA is generally synthesised from naturally occurring safrole, extracted from the sassafras tree, making it a semi-synthetic drug.

	= Legal Status =		== Legal Status ==

	MDMA is legally controlled in most of the world under the UN Convention on Psychotropic Substances and other international agreements, although exceptions exist for research and limited medical use. In general, the unlicensed use, sale or manufacture of MDMA are all criminal offences.		MDMA is legally controlled in most of the world under the UN Convention on Psychotropic Substances and other international agreements, although exceptions exist for research and limited medical use. In general, the unlicensed use, sale or manufacture of MDMA are all criminal offences.
	= Images =
			== Images ==

	<gallery mode="packed-hover">		<gallery mode="packed-hover">
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	</gallery>		</gallery>

	= Links =		== Links ==

	[https://pay.reddit.com/r/Borax/comments/w5c1x/a_stepbystep_guide_to_reducing_mdma_neurotoxicity/ A step-by-step guide to reducing MDMA neurotoxicity]		[https://pay.reddit.com/r/Borax/comments/w5c1x/a_stepbystep_guide_to_reducing_mdma_neurotoxicity/ A step-by-step guide to reducing MDMA neurotoxicity]

Sundown: /* Images */

2014-12-06T04:35:47Z

Images

← Older revision		Revision as of 23:35, 5 December 2014
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	Image:Bitcoin.png\|''Bitcoin MDMA Pill''		Image:Bitcoin.png\|''Bitcoin MDMA Pill''
	Image:Mdma3.png\|''MDMA Crystals''		Image:Mdma3.png\|''MDMA Crystals''
	Image:~~Mdma5~~.jpg\|''MDMA Crystals''		Image:Mdma7.jpg\|''MDMA Crystals''
	</gallery>		</gallery>

Sundown: /* Images */

2014-12-05T18:18:33Z

Images

← Older revision		Revision as of 13:18, 5 December 2014
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	Image:Bitcoin.png\|''Bitcoin MDMA Pill''		Image:Bitcoin.png\|''Bitcoin MDMA Pill''
	Image:Mdma3.png\|''MDMA Crystals''		Image:Mdma3.png\|''MDMA Crystals''
	Image:Mdma5.~~png~~\|''MDMA Crystals''		Image:Mdma5.jpg\|''MDMA Crystals''
	</gallery>		</gallery>