Hydrocodone - Revision history

Kryptlock: /* Warning */

2023-12-13T18:48:06Z

Warning

← Older revision		Revision as of 13:48, 13 December 2023
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	Excessive alcohol/grapefruit juice drinking while taking drug that contains APAP, can cause liver damage, other severe medical conditions, and even death.		Excessive alcohol/grapefruit juice drinking while taking drug that contains APAP, can cause liver damage, other severe medical conditions, and even death.

	[https://wiki.tripsit.me/wiki/Cold_Water_Extraction ~~Please consider~~ CWE if your hydrocodone contains APAP], as APAP is harmful to your liver and doctors recommend no more than 4g.		Please consider [https://wiki.tripsit.me/wiki/Cold_Water_Extraction CWE] if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.

	=== Potentiators ===		=== Potentiators ===

Kryptlock: /* Warning */

2023-12-13T18:45:59Z

Warning

← Older revision		Revision as of 13:45, 13 December 2023
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	Excessive alcohol/grapefruit juice drinking while taking drug that contains APAP, can cause liver damage, other severe medical conditions, and even death.		Excessive alcohol/grapefruit juice drinking while taking drug that contains APAP, can cause liver damage, other severe medical conditions, and even death.

	Please consider CWE if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.		[https://wiki.tripsit.me/wiki/Cold_Water_Extraction Please consider CWE if your hydrocodone contains APAP], as APAP is harmful to your liver and doctors recommend no more than 4g.

	=== Potentiators ===		=== Potentiators ===

Sleep: fixedit

2015-04-15T21:27:34Z

fixedit

← Older revision		Revision as of 16:27, 15 April 2015
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	\|+ Oral		\|+ Oral
	\|-		\|-
	\| ~~No Tolerance~~ \|\| 10mg		\| Light \|\| 5-10mg
	\|-		\|-
	\| ~~Low Tolerance~~ \|\| 20-~~30mg~~		\| Common \|\| 10-25mg
	\|-		\|-
	\| ~~Medium Tolerance~~ \|\| 30-~~50mg~~		\| Strong \|\| 25-40mg+
	\|-
	~~\| High Tolerance \|\| 60mg~~
	\|}		\|}

GrimReaper at 10:40, 10 March 2015

2015-03-10T10:40:55Z

← Older revision		Revision as of 05:40, 10 March 2015
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	The relative milligramme strength of hydrocodone to codeine is given as 6 fold, that is 5 mg has the effect of 30 mg of codeine; by way of the Roman numeral VI this is said to given rise to the trade name '''Vicodin'''.		The relative milligramme strength of hydrocodone to codeine is given as 6 fold, that is 5 mg has the effect of 30 mg of codeine; by way of the Roman numeral VI this is said to given rise to the trade name '''Vicodin'''.

	= History =		== History ==
	Hydrocodone was first synthesized in Germany in 1920 by Carl Mannich and Helene Löwenheim. Hydrocodone is derived from codeine. As a semi-synthetic opioid, it is most often used orally as a narcotic analgesic and antitussive. Used mostly in combination with Acetaminophen (Vicodin) or Ibuprofen. If you have a drug with acetaminophen in it, we strongly recommend you cold water (CWE) extract the acetaminophen away. CWE methods can be found [http://wiki.tripsit.me/wiki/Cold_Water_Extraction Here]		Hydrocodone was first synthesized in Germany in 1920 by Carl Mannich and Helene Löwenheim. Hydrocodone is derived from codeine. As a semi-synthetic opioid, it is most often used orally as a narcotic analgesic and antitussive. Used mostly in combination with Acetaminophen (Vicodin) or Ibuprofen. If you have a drug with acetaminophen in it, we strongly recommend you cold water (CWE) extract the acetaminophen away. CWE methods can be found [http://wiki.tripsit.me/wiki/Cold_Water_Extraction Here]

	= Dosage =		== Dosage ==
	Hydrocodone is a prodrug, insufflated and intravenous dosing is dangerous.		Hydrocodone is a prodrug, insufflated and intravenous dosing is dangerous.

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	Recommended dosing interval is 4–6 hours.		Recommended dosing interval is 4–6 hours.

	= Duration =		== Duration ==
	{\| class="wikitable"		{\| class="wikitable"
	\|+ Oral		\|+ Oral
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	Half-Life depends on a lot of factors such as weight, BMI, and metabolism, but average plasma half-life is 3.8 hours.		Half-Life depends on a lot of factors such as weight, BMI, and metabolism, but average plasma half-life is 3.8 hours.

	= Effects =		== Effects ==
	== Positive ==		=== Positive ===
	* Improvement of mood		* Improvement of mood
	* Reduction of pain		* Reduction of pain
	* Euphoria		* Euphoria

	== Neutral ==		=== Neutral ===
	* Itching		* Itching
	* Light-headedness		* Light-headedness
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	* Changes in focus and attention		* Changes in focus and attention

	== Negative ==		=== Negative ===
	* Dizziness		* Dizziness
	* Constipation		* Constipation
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	* When insufflated, burning in nose and sinuses		* When insufflated, burning in nose and sinuses

	= Chemistry and Pharmacology =		== Chemistry and Pharmacology ==
	As a narcotic, hydrocodone relieves pain by binding to opioid receptors in the CNS. It acts primarily on μ-opioid receptors, with about six times lesser affinity to δ-opioid receptors. In blood, 20–50% of hydrocodone is bound to protein.		As a narcotic, hydrocodone relieves pain by binding to opioid receptors in the CNS. It acts primarily on μ-opioid receptors, with about six times lesser affinity to δ-opioid receptors. In blood, 20–50% of hydrocodone is bound to protein.

	Studies have shown hydrocodone is stronger than codeine but only one-tenth as potent as morphine at binding to receptors and reported to be only 59% as potent as morphine in analgesic properties. However, in tests conducted on rhesus monkeys, the analgesic potency of hydrocodone was actually higher than morphine. Per os hydrocodone has a mean equivalent daily dosage (MEDD) factor of 0.4, meaning that 1 mg of hydrocodone is equivalent to 0.4 mg of intravenous morphine. However, because of morphine's low oral bioavailability, there is a 1:1 correspondence between orally administered morphine and orally administered hydrocodone.		Studies have shown hydrocodone is stronger than codeine but only one-tenth as potent as morphine at binding to receptors and reported to be only 59% as potent as morphine in analgesic properties. However, in tests conducted on rhesus monkeys, the analgesic potency of hydrocodone was actually higher than morphine. Per os hydrocodone has a mean equivalent daily dosage (MEDD) factor of 0.4, meaning that 1 mg of hydrocodone is equivalent to 0.4 mg of intravenous morphine. However, because of morphine's low oral bioavailability, there is a 1:1 correspondence between orally administered morphine and orally administered hydrocodone.

	= Harm Reduction =		== Harm Reduction ==
	== Warning ==		=== Warning ===
	Any dose of Hydrocodone may be fatal. Do not mix with other drugs or alcohol.		Any dose of Hydrocodone may be fatal. Do not mix with other drugs or alcohol.

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	Please consider CWE if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.		Please consider CWE if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.

	== Potentiators ==		=== Potentiators ===

	The following products may react negatively with hydrocodone and may cause overdose if mixed together.		The following products may react negatively with hydrocodone and may cause overdose if mixed together.
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	*Diphenhydramine		*Diphenhydramine

	= Legal status =		== Legal status ==

	*Australia - In Australia, hydrocodone is a Schedule 8 (S8) or Controlled Drug.		*Australia - In Australia, hydrocodone is a Schedule 8 (S8) or Controlled Drug.
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	* DeNoon, Daniel J. (April 20, 2011). "The 10 Most Prescribed Drugs". eMedicineHealth. Retrieved 16 August 2012.		* DeNoon, Daniel J. (April 20, 2011). "The 10 Most Prescribed Drugs". eMedicineHealth. Retrieved 16 August 2012.

	= Links =		== Links ==

	[http://en.wikipedia.org/wiki/Hydrocodone Wikipedia]		[http://en.wikipedia.org/wiki/Hydrocodone Wikipedia]
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	[[Category:Opioid]]		[[Category:Opioid]]
			[[Category:Depressant]]
	[[Category:Drugs]]		[[Category:Drugs]]

GrimReaper at 14:19, 16 July 2014

2014-07-16T14:19:43Z

← Older revision		Revision as of 09:19, 16 July 2014
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	Half-Life depends on a lot of factors such as weight, BMI, and metabolism, but average plasma half-life is 3.8 hours.		Half-Life depends on a lot of factors such as weight, BMI, and metabolism, but average plasma half-life is 3.8 hours.

			= Effects =
			== Positive ==
			* Improvement of mood
			* Reduction of pain
			* Euphoria

			== Neutral ==
			* Itching
			* Light-headedness
			* Sedation
			* Changes in focus and attention

			== Negative ==
			* Dizziness
			* Constipation
			* Nausea and vomiting
			* When insufflated, burning in nose and sinuses

	= Chemistry and Pharmacology =		= Chemistry and Pharmacology =

GrimReaper at 14:16, 16 July 2014

2014-07-16T14:16:48Z

← Older revision		Revision as of 09:16, 16 July 2014
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			[[File:Hydrocodone.jpg\|right]]
	'''Hydrocodone''' is a semi-synthetic opioid derived from codeine. Hydrocodone is used orally as a narcotic analgesic and antitussive (cough medicine), often in combination with paracetamol (acetaminophen) or ibuprofen. Hydrocodone is prescribed predominantly within the United States; elsewhere it is rare. The International Narcotics Control Board reported 99% of the worldwide supply in 2007 was consumed in the United States.		'''Hydrocodone''' is a semi-synthetic opioid derived from codeine. Hydrocodone is used orally as a narcotic analgesic and antitussive (cough medicine), often in combination with paracetamol (acetaminophen) or ibuprofen. Hydrocodone is prescribed predominantly within the United States; elsewhere it is rare. The International Narcotics Control Board reported 99% of the worldwide supply in 2007 was consumed in the United States.

GrimReaper at 14:12, 16 July 2014

2014-07-16T14:12:49Z

← Older revision		Revision as of 09:12, 16 July 2014
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	== History ==
			'''Hydrocodone''' is a semi-synthetic opioid derived from codeine. Hydrocodone is used orally as a narcotic analgesic and antitussive (cough medicine), often in combination with paracetamol (acetaminophen) or ibuprofen. Hydrocodone is prescribed predominantly within the United States; elsewhere it is rare. The International Narcotics Control Board reported 99% of the worldwide supply in 2007 was consumed in the United States.

			The relative milligramme strength of hydrocodone to codeine is given as 6 fold, that is 5 mg has the effect of 30 mg of codeine; by way of the Roman numeral VI this is said to given rise to the trade name '''Vicodin'''.

			= History =
	Hydrocodone was first synthesized in Germany in 1920 by Carl Mannich and Helene Löwenheim. Hydrocodone is derived from codeine. As a semi-synthetic opioid, it is most often used orally as a narcotic analgesic and antitussive. Used mostly in combination with Acetaminophen (Vicodin) or Ibuprofen. If you have a drug with acetaminophen in it, we strongly recommend you cold water (CWE) extract the acetaminophen away. CWE methods can be found [http://wiki.tripsit.me/wiki/Cold_Water_Extraction Here]		Hydrocodone was first synthesized in Germany in 1920 by Carl Mannich and Helene Löwenheim. Hydrocodone is derived from codeine. As a semi-synthetic opioid, it is most often used orally as a narcotic analgesic and antitussive. Used mostly in combination with Acetaminophen (Vicodin) or Ibuprofen. If you have a drug with acetaminophen in it, we strongly recommend you cold water (CWE) extract the acetaminophen away. CWE methods can be found [http://wiki.tripsit.me/wiki/Cold_Water_Extraction Here]

	== Dosage ==		= Dosage =
			Hydrocodone is a prodrug, insufflated and intravenous dosing is dangerous.

	The following refers to hydrocodone in the form of hydrocodone mixture with Acetaminophen/Ibuprofen.		The following refers to hydrocodone in the form of hydrocodone mixture with Acetaminophen/Ibuprofen.
	~~'''WE ARE NOT DOCTORS. CONSUME THE DOSAGES BELOW AT YOUR OWN RISK.'''~~

	~~Any dose of Hydrocodone may be fatal. Do not mix with other drugs or alcohol~~.		{\| class="wikitable"
			\|+ Oral
			\|-
			\| No Tolerance \|\| 10mg
			\|-
			\| Low Tolerance \|\| 20-30mg
			\|-
			\| Medium Tolerance \|\| 30-50mg
			\|-
			\| High Tolerance \|\| 60mg
			\|}

			Recommended dosing interval is 4–6 hours.

			= Duration =
			{\| class="wikitable"
			\|+ Oral
			\|-
			\| Onset \|\| 10-30 minutes
			\|-
			\| Total duration \|\| 4-6 hours
			\|}

	*No Tolerance - ~~10mg~~		Half-Life depends on a lot of factors such as weight, BMI, and metabolism, but average plasma half-life is 3.8 hours.
	*Low Tolerance - ~~20-30mg~~
	*Medium Tolerance - 30-50mg
	*High Tolerance - 60mg

	== ~~Onset ==~~		= Chemistry and Pharmacology =
			As a narcotic, hydrocodone relieves pain by binding to opioid receptors in the CNS. It acts primarily on μ-opioid receptors, with about six times lesser affinity to δ-opioid receptors. In blood, 20–50% of hydrocodone is bound to protein.

	~~Oral~~: ~~10 - 30 minutes~~		Studies have shown hydrocodone is stronger than codeine but only one-tenth as potent as morphine at binding to receptors and reported to be only 59% as potent as morphine in analgesic properties. However, in tests conducted on rhesus monkeys, the analgesic potency of hydrocodone was actually higher than morphine. Per os hydrocodone has a mean equivalent daily dosage (MEDD) factor of 0.4, meaning that 1 mg of hydrocodone is equivalent to 0.4 mg of intravenous morphine. However, because of morphine's low oral bioavailability, there is a 1:1 correspondence between orally administered morphine and orally administered hydrocodone.

	~~Insufflated - It's a prodrug, don't do it~~.		= Harm Reduction =
			== Warning ==
			Any dose of Hydrocodone may be fatal. Do not mix with other drugs or alcohol.

	~~IV - It's a prodrug~~, ~~don't do it~~.		Excessive alcohol/grapefruit juice drinking while taking drug that contains APAP, can cause liver damage, other severe medical conditions, and even death.

	~~Half-Life depends on a lot of factors such~~ as ~~weight, BMI,~~ and ~~metabolism, but average plasma half-life is 3.8 hours~~.		Please consider CWE if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.

	== Potentiators ==		== Potentiators ==
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	*Grapefruit Juice		*Grapefruit Juice
	*Diphenhydramine		*Diphenhydramine

	~~== Warning ==~~

	~~Excessive alcohol/grapefruit juice drinking while taking drug that contains APAP, can cause liver damage, other severe medical conditions, and even death.~~

	~~== Harm Reduction ==~~

	~~Do not consume alcohol while under the influence of Hydrocodone.~~
	~~Please consider CWE if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.~~

	= Legal status =		= Legal status =
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	* "Medical News: FDA Pulls Plug on 200-Plus Unapproved Cough Syrups With Hydrocodone—in Product Alert, Prescriptions from". MedPage Today. Retrieved 2010-08-22.		* "Medical News: FDA Pulls Plug on 200-Plus Unapproved Cough Syrups With Hydrocodone—in Product Alert, Prescriptions from". MedPage Today. Retrieved 2010-08-22.
	* DeNoon, Daniel J. (April 20, 2011). "The 10 Most Prescribed Drugs". eMedicineHealth. Retrieved 16 August 2012.		* DeNoon, Daniel J. (April 20, 2011). "The 10 Most Prescribed Drugs". eMedicineHealth. Retrieved 16 August 2012.

			= Links =

			[http://en.wikipedia.org/wiki/Hydrocodone Wikipedia]

			[http://www.erowid.org/pharms/hydrocodone/hydrocodone.shtml Erowid]

	[[Category:Opioid]]		[[Category:Opioid]]
	[[Category:Drugs]]		[[Category:Drugs]]

Sleep: /* Onset */

2014-05-07T23:30:14Z

Onset

← Older revision		Revision as of 18:30, 7 May 2014
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	Oral: 10 - 30 minutes		Oral: 10 - 30 minutes

	Insufflated - ~~Not recommended as snorting APAP is never nice~~.		Insufflated - It's a prodrug, don't do it.

	IV - ~~Not recommended~~.		IV - It's a prodrug, don't do it.

	Half-Life depends on a lot of factors such as weight, BMI, and metabolism, but average plasma half-life is 3.8 hours.		Half-Life depends on a lot of factors such as weight, BMI, and metabolism, but average plasma half-life is 3.8 hours.

	== Potentiators ==		== Potentiators ==

Sleep: /* History */

2014-05-07T23:28:48Z

History

← Older revision		Revision as of 18:28, 7 May 2014
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	== History ==		== History ==

	Hydrocodone was first synthesized in Germany in 1920 by Carl Mannich and Helene Löwenheim. Hydrocodone is derived from codeine. As a semi-synthetic opioid, it is most often used orally as a narcotic analgesic and antitussive. Used mostly in combination with Acetaminophen (Vicodin) or Ibuprofen. If you have a drug with acetaminophen in it, we strongly recommend you cold water (CWE) extract the acetaminophen away. CWE methods can be found ~~on Google~~.		Hydrocodone was first synthesized in Germany in 1920 by Carl Mannich and Helene Löwenheim. Hydrocodone is derived from codeine. As a semi-synthetic opioid, it is most often used orally as a narcotic analgesic and antitussive. Used mostly in combination with Acetaminophen (Vicodin) or Ibuprofen. If you have a drug with acetaminophen in it, we strongly recommend you cold water (CWE) extract the acetaminophen away. CWE methods can be found [http://wiki.tripsit.me/wiki/Cold_Water_Extraction Here]

	== Dosage ==		== Dosage ==

Roi at 10:43, 23 April 2014

2014-04-23T10:43:50Z

← Older revision		Revision as of 05:43, 23 April 2014
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	Please consider CWE if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.		Please consider CWE if your hydrocodone contains APAP, as APAP is harmful to your liver and doctors recommend no more than 4g.

	=~~= Legality =~~=		= Legal status =

	*Australia - In Australia, hydrocodone is a Schedule 8 (S8) or Controlled Drug.		*Australia - In Australia, hydrocodone is a Schedule 8 (S8) or Controlled Drug.